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Yi-Chih Chang

Yi-Chih Chang (張益銍) Assistant Professor

➤ Education
National Chung Hsing University Doctor
National Yang-Ming University Master
China Medical University Bachelor
➤ Experience
China Medical University (820801~ 880731)
China Medical University Department of? Medical? Laboratory? Science and Biotechnology Lecturer
China Medical University Department of? Medical? Laboratory? Science and Biotechnology Assistant Professor
Extracurricular Activities Section Chief
➤ TEL
+886-4-23323456 ext.20027
➤ Lab
HB27
➤ Research Areas
Molecular Bacteriology, Biotechnology, Microbiology, Immunology, Clinical microbiology, Clinical microscope, Diagnotic cytology, Diagnotic toxicology
◉ Journal Papers
  • Chang YC*, Tien N, Yang JS, Lu CC, Tsai FJ, Huang TJ, Wang IK. Class 1 integrons and plasmid-mediated multiple resistance genes of the Campylobacter species from pediatric patient of a university hospital in Taiwan. Gut Pathog. 2017 Sep 9;9:50-57. (Impact Factor：2.809)
  • Chiu CC, Wang YC, Huang WC, Chen YH, Hung SW, Huang YT, Chuang HL, Chang YC*. Differences in Genetic Background Contribute to Pseudomonas Exotoxin A-Induced Hepatotoxicity in Rats. Toxins (Basel). 2017 Jul 15;9(7). (Impact Factor：3.273)
  • Chang YC, Ching YH, Chiu CC, Liu JY, Hung SW, Huang WC, Huang YT, Chuang HL. TLR2 and interleukin-10 are involved in Bacteroides fragilis-mediated prevention of DSS-induced colitis in gnotobiotic mice. PLoS One. 2017 Jul 6;12(7):e0180025. (Impact Factor：2.766)
  • Lu CY, Chang YC, Hua CH, Chuang C, Huang SH, Kung SH, Hour MJ, Lin CW. Tubacin, an HDAC6 Selective Inhibitor, Reduces the Replication of the Japanese Encephalitis Virus via the Decrease of Viral RNA Synthesis. Int J Mol Sci. 2017 May 1;18(5). (Impact Factor：3.687)
  • Huang HH, Chen WC, Lin CW, Lin YT, Ning HC, Chang YC*, Yang TC*. Relationship of the CreBC two-component regulatory system and inner membrane protein CreD with swimming motility in Stenotrophomonas maltophilia. PLoS One. 2017 Apr 24;12(4):e0174704. (Impact Factor：2.766)
  • Huang YW, Lin CW, Ning HC, Lin YT, Chang YC*, Yang TC*. Overexpression of SmeDEF Efflux Pump Decreases Aminoglycoside Resistance in Stenotrophomonas maltophilia. Antimicrob Agents Chemother. 2017 Apr 24;61(5). (Impact Factor：4.255)
  • Liao SW, Lee JJ; Chen F, Lee WC, Wu YC, Hsuan SL, Kuo CJ, Chang YC*, Chen TH*. Evaluation of lung scoring system and serological analysis of Actinobacillus pleuropneumoniae infection in pigs. Pakistan Veterinary Journal 2017. 37(3): 340-344. (Impact Factor：1.217)
  • Wu YC, Chen CM, Kuo CJ, Lee JJ, Chen PC, Chang YC*, Chen TH*. Prevalence and molecular characterization of Clostridium difficile isolates from a pig slaughterhouse, pork, and humans in Taiwan. Int J Food Microbiol. 2017 Feb 2;242:37-44. (Impact Factor：3.451)
  • Lin SJ, Su TC, Chu CN, Chang YC, Yang LM, Kuo YC, Huang TJ. Synthesis of C-4-Substituted Steviol Derivatives and Their Inhibitory Effects against Hepatitis B Virus. J Nat Prod. 2016 Dec 23;79(12):3057-3064. (Impact Factor：3.885)
  • Wang YC, Tsai CF, Chuang HL, Chang YC, Chen HS, Lee JN, Tsai EM. Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling. Oncotarget. 2016 May 17;7(20):29563-76. (Impact Factor：5.168)
  • Chang YC, Yu CH, Liang WM, Tu MG, Chen SY. Comparison of the surface roughness of gypsum models constructed using various impression materials and gypsum products. Journal of Dental Sciences. 2016 Mar 11(1):23-28(Impact Factor：0.619)
  • Tien N, Sung YJ, Chang YC, You BJ, Liang M, Lim YP, Ho WY, Lin HS, Ho MW, Ho CM, Chang CC, Lan YC. The medical diagnostic approaches with phylogenetic analysis for rare Brucella spp. diagnosis in Taiwan. Biomedicine (Taipei). 2015 Jun;5(2):9. (Impact Factor：0.5)
  • Huang TJ, Yang CL, Kuo YC, Chang YC, Yang LM, Chou BH, Lin SJ. Synthesis and anti-hepatitis B virus activity of C4 amide-substituted isosteviol derivatives. Bioorg Med Chem. 2015 Feb 15;23(4):720-8. (Impact Factor：2.442)
  • Huang TJ, Tsai YC, Chiang SY, Wang GJ, Kuo YC, Chang YC, Wu YY, Wu YC. Anti-viral effect of a compound isolated from Liriope platyphylla against hepatitis B virus in vitro. Virus Res. 2014 Nov 4; 192:16-24. (Impact Factor：2.484)
  • Lin YT, Huang YW, Liou RS, Chang YC, Yang TC. MacABCsm, an ABC-type tripartite efflux pump of Stenotrophomonas maltophilia involved in drug resistance, oxidative and envelope stress tolerances and biofilm formation. J Antimicrob Chemother. 2014 Dec;69(12):3221-6. (Impact Factor：5.217)
  • Chiu CC, Huang YT, Wang YC, Chang YC, Ching YH, Chen HH, Chuang HL. Pretreatment with lipopolysaccharide ameliorates Pseudomonas exotoxin A-induced hepatotoxicity in rats. Immunopharmacol Immunotoxicol. 2013 Apr;35(2):296-303. (Impact Factor：2.024)
  • Wang IK, Muo CH, Chang YC, Liang CC, Chang CT, Lin SY, Yen TH, Chuang FR, Chen PC, Huang CC, Wen CP, Sung FC, Morisky DE. Association between hypertensive disorders during pregnancy and end-stage renal disease: a population-based study. CMAJ. 2013 Feb 19;185(3):207-13. (Impact Factor：6.21)
  • Wang IK, Lin CL, Chang YC, Lin PC, Liang CC, Liu YL, Chang CT, Yen TH, Huang CC, Sung FC. Effectiveness of influenza vaccination in elderly diabetic patients: a retrospective cohort study. Vaccine. 2013 Jan 11;31(4):718-24. (Impact Factor：3.285)
  • Hsiang CY, Hseu YC, Chang YC, Kumar KJ, Ho TY, Yang HL. Toona sinensis and its major bioactive compound gallic acid inhibit LPS-induced inflammation in nuclear factor-κB transgenic mice as evaluated by in vivo bioluminescence imaging. Food Chem. 2013 Jan 15;136(2):426-34. (Impact Factor：4.946)
  • Chang TN, Deng JS, Chang YC, Lee CY, Jung-Chun L, Lee MM, Peng WH, Huang SS, Huang GJ. Ameliorative Effects of Scopoletin from Crossostephium chinensis against Inflammation Pain and Its Mechanisms in Mice. Evid Based Complement Alternat Med. 2012;2012:595603. (Impact Factor：2.064)
  • Chang YC, Huang JY, Chiou MT, Chung TC, Hsu WL, Lin CF. Characterization of a small cryptic plasmid pK50-2 isolated from Lactobacillus reuteri K50. Plasmid. 2013 Jan;69(1):58-66. (Impact Factor：2.228)
  • Chang SJ, Chang YC, Lu KZ, Tsou YY, Lin CW. Antiviral Activity of Isatis indigotica Extract and Its Derived Indirubin against Japanese Encephalitis Virus. Evid Based Complement Alternat Med. 2012. 2012:925830. (Impact Factor：2.064)
  • Wang IK, Muo CH, Chang YC, Liang CC, Lin SY, Chang CT, Yen TH, Chuang FR, Chen PC, Huang CC, Sung FC. Risks, subtypes, and hospitalization costs of stroke among patients with systemic lupus erythematosus: a retrospective cohort study in Taiwan. J Rheumatol. 2012 Aug;39(8):1611-8. (Impact Factor：3.47)
  • Wang IK, Chang YC, Liang CC, Chuang FR, Chang CT, Lin HH, Lin CC, Yen TH, Lin PC, Chou CY, Huang CC, Tsai WC, Chen JH. Bacteremia in hemodialysis and peritoneal dialysis patients. Intern Med. 2012;51(9):1015-21. (Impact Factor：1.785)
  • Wang IK, Kung PT, Kuo WY, Tsai WC, Chang YC, Liang CC, Chang CT, Yeh HC, Wang SM, Chuang FR, Wang KY, Lin CY, Huang CC. Impact of dialysis modality on the survival of end-stage renal disease patients with or without cardiovascular disease. J Nephrol. 2013 Mar-Apr;26(2):331-41. (Impact Factor：2.724)
  • Lin YJ, Chang YC, Hsiao NW, Hsieh JL, Wang CY, Kung SH, Tsai FJ, Lan YC, Lin CW. Fisetin and rutin as 3C protease inhibitors of enterovirus A71. J Virol Methods. 2012 Jun;182(1-2):93-8. (Impact Factor：1.756)
  • Wang IK, Lai HC, Yu CJ, Liang CC, Chang CT, Kuo HL, Yang YF, Lin CC, Lin HH, Liu YL, Chang YC, Wu YY, Chen CH, Li CY, Chuang FR, Huang CC, Lin CH, Lin HC. Real-time PCR analysis of the intestinal microbiotas in peritoneal dialysis patients. Appl Environ Microbiol. 2012 Feb;78(4):1107-12. (Impact Factor：)
  • Chang YC, Tsai CY, Lin CF, Wang YC, Wang IK, Chung TC. Characterization of tetracycline resistance lactobacilli isolated from swine intestines at western area of Taiwan. Anaerobe. 2011 Oct;17(5):239-45. (Impact Factor：2.742)
  • Wang YC, Chang YC, Chuang HL, Chiu CC, Yeh KS, Chang CC, Hsuan SL, Lin WH, Chen TH. Transmission of Salmonella between swine farms by the housefly (Musca domestica). J Food Prot. 2011 Jun;74(6):1012-6. (Impact Factor：1.51)
  • Chang YC, Tsai MJ, Huang YW, Chung TC, Yang TC. SmQnrR, a DeoR-type transcriptional regulator, negatively regulates the expression of Smqnr and SmtcrA in Stenotrophomonas maltophilia. J Antimicrob Chemother. 2011 May;66(5):1024-8. (Impact Factor：5.217)
  • Wang YC, Chan JP, Yeh KS, Chang CC, Hsuan SL, Hsieh YM, Chang YC, Lai TC, Lin WH, Chen TH. Molecular characterization of enrofloxacin resistant Actinobacillus pleuropneumoniae isolates. Vet Microbiol. 2010 May 19;142(3-4):309-12. (Impact Factor：2.524)
  • Hu RM, Chiang KH, Chang YC, Yang TC. Characterization of the charge variants of L2 beta-lactamase in Stenotrophomonas maltophilia. J Med Microbiol. 2009 Mar;58(Pt 3):318-21. (Impact Factor：2.112)
  • Lin CC, Chen TH, Wang YC, Chang CC, Hsuan SL, Chang YC, Yeh KS. Analysis of ciprofloxacin-resistant Salmonella strains from swine, chicken, and their carcasses in Taiwan and detection of parC resistance mutations by a mismatch amplification mutation assay PCR. J Food Prot. 2009 Jan;72(1):14-20. (Impact Factor：1.51)
  • Cheng JC, Huang CL, Lin CC, Chen CC, Chang YC, Chang SS, Tseng CP. Rapid detection and identification of clinically important bacteria by high-resolution melting analysis after broad-range ribosomal RNA real-time PCR. Clin Chem. 2006 Nov;52(11):1997-2004. (Impact Factor：8.636)
  • Wu CM, Lin CF, Chang YC, Chung TC. Construction and characterization of nisin-controlled expression vectors for use in Lactobacillus reuteri. Biosci Biotechnol Biochem. 2006 Apr;70(4):757-67. (Impact Factor：1.255)
◉ Conference Papers
  • Analysis of erythromycin reisitance genes in Campylobacter species isolates from human, chicken and swine specimens, 107年度醫檢學會年度大會學術研討會, 台大醫院國際會議中心, 2018.11.3 ~ 2018.11.4
  • The antimicrobial susceptibility test of Stapylococcus aureus and beta-hemolytic streptococci by VITEK 2 system at east area of Taiwan, 2018年中國醫藥大學暨亞洲大學生物科技研討會, 中國醫藥大學B1國際會議廳, 2018.5.7 ~ 2018.5.7
  • Analysis the antimicrobial susceptibility test of Gram-Negative Bacilli by VITEK 2 system in Taitung Christian Hospital, Taitung, 2018年中國醫藥大學暨亞洲大學生物科技研討會, 中國醫藥大學B1國際會議廳, 2018.5.7 ~ 2018.5.7
  • Detection the major virulence genes (cytolethal distending toxin genes) in Campylobacter species isolates from human, chicken and swine specimens, 2018年中國醫藥大學暨亞洲大學生物科技研討會, 中國醫藥大學B1國際會議廳, 2018.5.7 ~ 2018.5.7
  • Detection the Pattern of Gene Cassette Arrays in Class I Integrin from Multidrug Resistance Clinical Klebsiella pneumoniae Isolates, TTQAS 第二屆第三次年會暨2017年化妝品最新研發趨勢、人體與動物試驗及品質監控研討會, 台灣大學凝態中心楊金豹演講廳, 2017.9.30 ~ 2017.9.30
  • Analysis of antibiotic resistance genes of Acinetobacter baumannii from medical center hospital in central Taiwan, 第十屆生物科技研討會(The 10th Biotechnology Conference), 亞洲大學A101國際會議廳, 2017.5.8 ~ 2017.5.8
  • The synergistic effects of Hsu-48 drug combined with five antibiotics against methicillin resistant Staphylococcus aureus, 第十屆生物科技研討會(The 10th Biotechnology Conference), 亞洲大學A101國際會議廳, 2017.5.8 ~ 2017.5.8
  • The additive effect of a new nordihydroguaiaretic acid derivative combined with five antibiotics against coagulase negative Staphylococcus epidermidis, 第十屆生物科技研討會(The 10th Biotechnology Conference), 亞洲大學A101國際會議廳, 2017.5.8 ~ 2017.5.8
  • Prevalence of tetracycline and erythromycin resistance gene from Campylobacter species at central Taiwan hospital, 第十屆生物科技研討會(The 10th Biotechnology Conference), 亞洲大學A101國際會議廳, 2017.5.8 ~ 2017.5.8
  • Molecular characterization of Campylobacter species isolated from pediatric gastroenteritis patients at central area of Taiwan, 台灣醫檢雜誌 (105年度年會大會), 台北國際會議中心, 2016.11.27 ~ 2016.11.27
  • Analysis the patterm of gene cassette arrays in class I integron from clinical Acinetobacter baumanni isolates at central area of Taiwan, 台灣醫檢雜誌 (105年度年會大會), 台北國際會議中心, 2016.11.27 ~ 2016.11.27
  • Antimicrobial susceptibility of Hsu-48 drug against the emergence of antimicrobial resistance beta-hemolytic streptococci in clinical isolates, 第九屆中國醫藥大學暨亞洲大學生物科技研討會, 中國醫藥大學立夫教學大樓B1國際會議廳, 2016.3.14 ~ 2016.3.14
  • Antimicrobial activity of synthetic analogues (Hsu-48 drug) against the emergence of antimicrobial resistance MRSA and coagulase-negative Staphylococci, 第九屆中國醫藥大學暨亞洲大學生物科技研討會, 中國醫藥大學立夫教學大樓B1國際會議廳, 2016.3.14 ~ 2016.3.14
  • Analysis of class I Integron from multiple drug resistance Acinetobacter baumanni in clinical isolates, 第九屆中國醫藥大學暨亞洲大學生物科技研討會, 中國醫藥大學立夫教學大樓B1國際會議廳, 2016.3.14 ~ 2016.3.14
  • YPH-PA3 promote macrophage differentiation of osteoclasts and promote autophagy, 中華民國免疫學會2015年會員大會暨學術研討會, 台灣大學醫學院一樓102、103和104講堂, 2015.10.24 ~ 2015.10.24
  • Antimicrobial activity of Hsu-48 drug (a new nordihydroguaiaretic acid derivative) in clinical emergency pathogens, 台灣微生物學會第二十一屆第三次台灣微生物學會年會暨會員大會, 台北國際會議中心, 2015.10.17 ~ 2015.10.17
  • NC-8 inhibits the osteoclast differentiation from Monocyte/ Macrophages Lineage precursor cell., 第七屆生物科技研討會, 本校國際會議廳, 2014.5.14 ~ 2014.5.14
  • Akebia saponin D of Chinese herbal medicine Mu-Tong Induces Osteoclast Differentiation From Monocyte/Macrophage Lineage Precursor Cells, 2013年亞太過敏氣喘及臨床免疫學會暨中華民國免疫學會第35週年年會, 台北國際會議中心, 2013.11.14 ~ 2013.11.17
  • Antimicrobial susceptibility of vanillin against several Lactobacillus species isolated from swine guts at the western area of Taiwan., 「益生菌及代謝物之多重應用」學術與產業應用研討會暨台灣乳酸菌協會第五屆第二次會員大會, 台灣大學凝態物理館2F國際會議廳, 2013.11.22 ~ 2013.11.22
  • Antimicrobial activity of vanillin against lactic acid bacteria isolated from indigenous children feces at the western area of Taiwan., 「益生菌及代謝物之多重應用」學術與產業應用研討會暨台灣乳酸菌協會第五屆第二次會員大會, 台灣大學凝態物理館2F國際會議廳, 2013.11.22 ~ 2013.11.22
  • Antimicrobial activity of vanillin to the emergence of antimicrobial resistance pathogens in clinical isolates., 第18屆細菌學研討會, 惠蓀實驗林場, 2013.8.29 ~ 2013.8.31
  • The mechanism of apotosis induced by Gallic acid in Human gastric epithelial Cells, APAPARI 2012暨中華民國免疫學會101年度年會, 台北圓山飯店, 2012.10.20 ~ 2012.10.21
  • Comparison of MRS medium and LSM medium for antimicrobial activity of tetracycline and ciprofloxacin in Lactobacillus species isolates., 第17屆細菌學研討會, 台中溪頭青年活動中心, 2012.8.29 ~ 2012.8.31
  • Lactobacillus can suppress the apoptosis that caused by Helicobacter pylori infection, 第三屆亞洲大學及中國醫藥大學生物技術聯合研討會, 亞洲大學, 2010.3.16 ~ 2010.3.16
  • Anti-Ciprofloxacin Activites of Lactobacillus species Isolated from Swine Guts at The Western Aera of Taiwan., 中華民國獸醫學會九十八年度聯合年會暨學術論文發表會, 國立台灣大學獸醫專業學院, 2009.12.19 ~ 2009.12.19
  • pROBIOTIC cHARACTER OF eNTEROCOCCUS FAECIUM ljs-o1-an Bacteriocin Producing Strain., 中華民國獸醫學會九十八年度聯合年會暨學術論文發表會, 國立台灣大學獸醫專業學院, 2009.12.19 ~ 2009.12.19
  • Upregulation of CCL20 and Recruitment of CCR6 Gastric Infiltrating Lymphocytes in Helicobacter pylori Gastritis., 97年度中國醫藥大學P3-4研究學習群之推廣, 2009研究學習群校級研究成果發表會, 日月潭教師會館, 2009.2.13 ~ 2009.2.14
  • Distribution of tet genes and antimicrobial susceptibility of several Lactobacillus species isolated from swine guts at the western area of Taiwan., 發酵乳的無可取代價值」學術研討會暨台灣乳酸菌協會第三屆第一次會員大會, 弘光科技大學生活應用大樓國際會議廳, 2008.12.5 ~ 2008.12.5
  • Antimicrobial Resistance and Genetic Relatedness among Salmonella Schwarzengrund from Slaughtering Broiler and Human, The 108th General Meeting of the American Society for Microbiology, Seaport Exhibition Center, Boston, MA, USA., 2008.6.1 ~ 2008.6.5
  • Investigation of Salmonella Infection in Household and Stray Dogs of Central Taiwan, The 108th General Meeting of the American Society for Microbiology, Seaport Exhibition Center, Boston, MA, USA., 2008.6.1 ~ 2008.6.5
  • The AmpR Protein Regulates the L1 β-Lactamase Expression in Stenotrophomonas maltophilia, The 108th General Meeting of the American Society for Microbiology, Seaport Exhibition Center, Boston, MA, USA., 2008.6.1 ~ 2008.6.5
  • The AmpR Protein Regulates the L1 beta-lactamase expression in Stenotrophomonas maltophilia, 108 屆美國微生物學會年會, 美國 Boston, 2008.6.1 ~ 2008.6.5
  • Antimicrobial activity of cultural secretions from probiotics Lactobacillus acidophilus against some antibiotic-resistant pathogens isolated from pediatric populations., 台灣微生物學會第四十週年慶會員大會學術研討會, 台北市臺大醫院國際會議中心, 2007.12.15 ~ 2007.12.16
  • Rapid detection of fluoroquinolone-resistant Salmonella by Multiplex Allele specific PCR, 第三屆沙門氏菌暨其他細菌人畜共通疾病研討會, 台中市 , 中興大學獸醫學院, 2007.7.7 ~ 2007.7.7
  • Characterization of anti-bacterial and cholesterol-lowering function for Enterococcus faecium 57a-1, 58a-1, and 63b-2, 台灣乳酸菌協會2006年年度大會暨學術研討會, 台北市 , 台灣大學凝態科學暨物理學館國際會議廳(二樓204室), 2006.11.3 ~ 2006.11.3
  • Distribution of tetracycline resistant genes in lactic acid bacteria isolated from human feces and swine guts in Taiwan, 台灣乳酸菌協會2006年年度大會暨學術研討會, 台北市 , 台灣大學凝態科學暨物理學館國際會議廳(二樓204室), 2006.11.3 ~ 2006.11.3
  • Correlation between the Allelic Variation of L2 Genes and Molecular Typing of Pulse Field Gel Electrophoresis in Stenotrophomonas maltophilia, 中華民國微生物學會年會, 台北, 臺大醫學院, 2005.12.25 ~ 2005.12.25
  • IDENTIFICATION OF HEPATITIS C VIRUS NS5B INTERACTING PROTEINS BY YEAST TWO-HYBRID SYSTEM, 九十二年度第十八屆生物醫學聯合學術年會, 台北市國防大學, 2003.3.22 ~ 2003.3.23
  • IDENTIFICATION OF HEPATITIS C VIRUS NS5B INTERACTING PROTEINS BY YEAST TWO-HYBRID SYSTEM, 九十二年度第十八屆生物醫學聯合學術年會, 台北市, 2003.3.22 ~ 2003.3.23
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