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黃元勵(Yuan-Li Huang) 專任教授/生科系主任

黃元勵 (Yuan-Li Huang) 專任教授/生科系主任

學歷
國立台灣大學 分子與細胞生物 博士
經歷
2009~2009 國立台灣大學生命科學系博士後研究員
2010~2014 亞洲大學生物科技學系助理教授
2014~迄今 亞洲大學生物科技學系副教授
分機
04-23323456#48048
研究室
8048(二宿)
研究領域
水解磷酸脂類在人類前列腺癌上所扮演的角色 巢蛋白在大鼠血管平滑肌細胞中表現
調控及功能性探討 各式中草藥之抗癌
抗血管動脈硬化機制探討
專長
細胞生物學、分子生物學、癌症生物學、細胞凋亡、訊號傳遞
授課科目
普通生物學、生物科技概論、內分泌學、遺傳學、生物化學、動物生長生物學、生物技術專題講座、專題討論、訊息傳遞、細胞生長與凋亡
期刊論文
  • Chen LY, Huang YL, Liu MY, Leu SF, Huang BM. (2003) Effects of amphetamine on steroidogenesis in MA-10 mouse Leydig tumor cells. Life Sci. 72(17):1983-1995 (SCI). [連結]
  • Hsu CC, Tsai SJ, Huang YL, Huang BM. (2003) Regulatory mechanism of Cordyceps sinensis mycelium on mouse Leydig cell steroidogenesis. FEBS Lett. 543(1-3):140-143 (SCI). [連結]
  • Hsu CC, Huang YL, Tsai SJ, Sheu CC, Huang BM. (2003) In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Life Sci. 73(16):2127-2136 (SCI). [連結]
  • Huang YL*, Leu SF, Liu BC, Sheu CC, Huang BM. (2004) In vivo stimulatory effect of Cordyceps sinensis mycelium and its fractions on reproductive functions in male mouse. Life Sci. 75(9):1051-1062 (SCI). [連結]
  • Lo HC, Yang JG, Liu BC, Chen YW, Huang YL, Poon SL, Liu MY, Huang BM. (2004) The effects of Tremella aurantia on testosterone and corticosterone productions in normal and diabetic rats. Arch Androl. 50(6):395-404 (SCI). [連結]
  • Chen YC, Huang YL, Huang BM. (2005) Cordyceps sinensis mycelium activates PKA and PKC signal pathways to stimulate steroidogenesis in MA-10 mouse Leydig tumor cells. Int J Biochem Cell B. 37(1):214-223 (SCI). [連結]
  • Wu HL, Lin CI, Huang YL, Chen PS, Kuo CH, Chen MS, Wu GC, Shi GY, Yang HY, Lee H. (2008) Lysophosphatidic acid stimulates thrombomodulin lectin-like domain shedding in human endothelial cells. Biochem Bioph Res Co. 367(1):162-168 (SCI). [連結]
  • Huang YL*, Shi GY, Jiang MJ, Lee H, Chou YW, Wu HL, Yang HY. (2008) Epidermal growth factor up-regulates the expression of nestin through the Ras-Raf-ERK signaling axis in rat vascular smooth muscle cells. Biochem Bioph Res Co. 377(2):361-366 (SCI). [連結]
  • Huang YL*, Shi GY, Lee H, Jiang MJ, Huang BM, Wu HL, Yang HY. (2009) Thrombin induces nestin expression via the transactivation of EGFR signalings in rat vascular smooth muscle cells. Cell Signal. 21(6):954-68 (SCI). [連結]
  • Huang YL*, Shi GY, Wu GCC, Lee H, Jiang MJ, Wu HL, Yang HY. (2009) Nestin serves as a prosurvival determinant that links to the cytoprotective effect of epidermal growth factor in rat vascular smooth muscle cells. J. Biochem. 146(3):307-15 (SCI). [連結]
  • Huang YL*, Lin HS, Chen SU, Lee H. (2009) Tyrosine sulphation of sphingosine 1-phosphate 1 (S1P1) is required for S1P-mediated cell migration in primary cultures of human umbilical vein endothelial cells. J. Biochem. 146(6):815-20 (SCI). [連結]
  • Lin PW, Huang YL*, Chen SU, Lee H. (2009) Lysophosphatidic acid up-regulates MT1-MMP expression through a Gi-dependent pathway in human umbilical vein endothelial cells. Taiwania 54(4): 375-80. [連結]
  • Huang YL*, Huang WP, Lee H. (2011) Roles of sphingosine 1-phosphate on tumorigenesis. W. J. Biol. Chem. 2(2): 25-34. [連結]
  • Tan TW, Huang YL*, Chang JT, Lin JJ, Fong YC, Kuo CC, Tsai CH, Chen YJ, Hsu HC, Cho DY, Chen YH, Tang CH. (2012) CCN3 increases BMP-4 expression and bone mineralization in osteoblasts. J. Cell. Physiol. 227(6): 2531-41 (SCI) [連結]
  • Tsai SY, Huang YL*, Yang WH, Tang CH. (2012) Hepatocyte growth factor-induced BMP-2 expression is mediated by c-Met receptor, FAK, JNK, Runx2, and p300 pathways in human osteoblasts. Int. Immunopharmacol. 13(2): 156-62 (SCI). [連結]
  • Lin YM, Huang YL, Fong YC, Tsai CH, Chou MC, Tang CH. (2012) Hepatocyte Growth Factor Increases Vascular Endothelial Growth Factor-A Production in Human Synovial Fibroblasts through c-Met Receptor Pathway. PLoS One. 7(11):e50924 [連結]
  • Liu JF, Huang YL*, Yang WH, Chang CS, Tang CH. (2012) 1-Benzyl-2-Phenylbenzimidazole (BPB), a Benzimidazole Derivative, Induces Cell Apoptosis in Human Chondrosarcoma through Intrinsic and Extrinsic Pathways. Int. J. Mol. Sci. 13(12):16472-88. [連結]
  • Chang CH, Huang YL*, Shyu MK, Chen SU, Lin CH, Ju TK, Lu JH, Lee H. (2013) Sphingosine -1-phosphate- induced vascular endothelial growth factor-C is MMP-2/FGF-1/FGFR-1-dependent in endothelial cells. Acta Pharmacol. Sin. 34(3):360-6. [連結]
  • Chang KW, Huang YL*, Wong ZR, Su PH, Huang BM, Ju TK, Yang HY. (2013) Fibroblast growth factor-2 up-regulates the expression of nestin through the Ras-Raf-ERK-Sp1 signaling axis in C6 glioma cells. Biochem Biophys Res Commun. 434(4):854-60. [連結]
  • Lee H, Chang KW, Yang HY, Lin PW, Chen SU, Huang YL*. (2013) MT1-MMP regulates MMP-2 expression and angiogenesis-related functions in human umbilical vein endothelial cells. Biochem. Biophys. Res. Commun. 437(2):232-238. [連結]
  • Wu PY, Lin YC, Lan SY, Huang YL, Lee H. (2013) Aromatic hydrocarbon receptor inhibits lysophosphatidic acid-induced vascular endothelial growth factor-A expression in PC-3 prostate cancer cells. Biochem. Biophys. Res. Commun. 437(3):440-445. [連結]
  • Lin CC, Lin CE, Lin YC, Ju TK, Huang YL, Lee MS, Chen JH, Lee H. (2013) Lysophosphatidic acid induces reactive oxygen species generation by activating protein kinase C in PC-3 human prostate cancer cells. Biochem. Biophys. Res. Commun. 440(4):564-569. [連結]
  • Huang YL*, Chang CL, Tang CH, Lin YC, Ju TK, Huang WP, Lee H. (2014) Extrinsic sphingosine 1-phosphate activates S1P5 and induces autophagy through generating endoplasmic reticulum stress in human prostate cancer PC-3 cells. Cell. Signal. 26(3):611-618. [連結]
  • Chuang JY, Huang YL*, Yen WL, Chiang IP, Tsai MH, Tan CH. (2014) Syk/JNK/AP-1 signaling pathway mediates interleukin-6-promoted cell migration in oral squamous cell carcinoma. Int. J. Mol. Sci. 15(1):545-559. [連結]
研討會論文
  • Huang YL*, Huang LM, Wang YK, Wu CS, Huang BM. The effects of Cordyceps sinensis on apoptosis in MA-10 mouse Leydig tumor cells. Society for the Study of Reproduction, 34th annual meeting, Ottawa, Canada 2001 (Abstract #389).
  • Chen YC, Huang YL, Huang BM. The mechanism of actions of Cordyceps sinensis on steroidogenesis in MA-10 mouse Leydig tumor cells. Society for the Study of Reproduction, 34th annual meeting, Ottawa, Canada 2001.
  • Huang YL*, Huang BM, Huang LM, Wu CS, Wang YK, Yang HY. Cordyceps sinensis induces MA-10 tumor cell apoptosis via activation of the caspase-8 and the suppression of NF-κB pathway. The 16th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2001. (poster #113)
  • Su PH, Lin YC, Ding IC, Wang TC, Huang YL, Wu GCC, Yang HY. Expression of plectin in the developing rat spinal cord. The 22nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2007.
  • Huang YL*, Su PH, Wang TC, Chou YW, Yang HY. EGF-induced phenotypic modulation of vascular smooth muscle cells through regulating the nestin expression. 15th International Vascular Biology Meeting, Sydney, Australia, 2008. (poster #P116)
  • Huang YL*, Su PH, Wu GCC, Wang TC, Chou YW, Chang KW, Yang HY. EGF-induced Phenotypic Modulation and Cytoprotective Effect in Vascular Smooth Muscle Cells through the Regulation of Nestin Expression. 4th International Symposium of the Kanagawa University - National Taiwan University Exchange Program, Taipei, Taiwan, 2008. (poster#P9)
  • Shih CJ, Huang YL*, Chang CL, Huang WP, Lee H. Sphingosine 1-phosphate-induced autophagy is mediated through activating endoplasmic reticulum stress response in human prostate cancer PC-3 cells. FASEB 2010: 954.9, 2010. (poster#P289)
  • Shih CJ, Lin YC, Huang YL, Chang CL, Huang WP, Lee H. Sphingosine 1-phosphate-induced autophagy is mediated through activating endoplasmic reticulum stress response in human prostate cancer PC-3 cells. At 2010 The Leading Graduate School International Conference, Tsukuba, Japan. 2010.
  • Huang YL*, Chang CL, Chiang HC, Shih CJ, Huang WP, Lee H. S1P1 and S1P5 are required for S1P-induced ER stress in human prostate cancer PC-3 cells. Keystone Symposia, Whistler, British Columbia, Canada. 2011. (poster#166)
  • Lin YC, Lin CE, Huang YL, Lee H. The study of androgen effect on LPA-induced VEGF-C expression in prostate cancer cell lines. ASCB2011, Denver, Colorado, USA, 2011.
  • Huang YL*, Lee H. De-cellularized human umbilical vein as a potential scaffold for personalized vascular tissue engineering. The 9th Kyoto U-NTU International Exchange Activity on Long-Distance Course, Kyoto, Japan, 2011.
  • 吳政宗, 黃元勵*, 王佑民, 曾郁茹, 莊采霓, 楊婕妤, 韓建國, 林俊義。添加舞菇粉對硬質餅乾品質之影響。台灣食品科技學會第41次年會, 嘉義, 台灣, 2011。
  • 黃元勵*, 林良蔚, 吳政宗, 王佑民, 陳宛霞, 韓建國, 林俊義。不同粒徑舞菇粉末添加對硬質餅乾之影響。台灣食品科技學會第41次年會, 嘉義, 台灣, 2011。
  • 黃元勵*, 陳宛霞, 吳政宗, 林良蔚, 黃仲億, 蔣豐懋, 韓建國, 林俊義。舞菇粉物理性質分析之探討。台灣食品科技學會第41次年會, 嘉義, 台灣, 2011。
  • Lin YC, Huang YL, Lee H. The study of androgen effects on LPA-induced ROS in different human prostate cancer cell lines. FASEB 2012: 657.11, 2012. (poster#P183)
  • Huang YL*, SU Chen, J Luand H Lee.Sphingosine 1-phosphate potentiated endothelial cell attachment on de-cellularized human umbilical vein as a scaffold for vascular tissue engineering. FASEB 2012: 905.25, 2012. (poster#P295)
  • Lin YC, Huang YL, Lee H. The study of androgen effects on LPA-induced ROS in different human prostate cancer cell lines. At The 7th Tsukuba Medical Science Research Meeting, Tsukuba, Japan. 2012. (Oral presentation & Poster)
  • Huang CY, Yang CY, Cheng YH, Huang YL. Sphingosine 1-phosphate (S1P) inhibits a human prostate cancer PC-3 cell survival via a S1P1-dependent signaling pathway. The 27nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2012. (poster#790)
  • Zeng YR, Huang CY, Chen WS, Chuang TN, Huang YL. S1P suppresses cell survival through the Gq-dependent signaling pathway in PC-3 cells. The 27nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2012. (poster#791)
  • Chuang TN, Ke SY, Zeng YR, Lin LW, Huang YL. Lysophosphatidic acid inhibits autophagy in human prostate cancer PC-3 cells upon serum deprivation. The 27nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2012. (poster#792)
  • Wang YM*, Huang YL*, Han JG, Lin CY. The effects of different extraction time and temperature on the yield of polysaccharide from Tremella powder. The 27nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2012. (poster#793)
  • Wang YM*, Huang YL*, Zeng YR, Chuang TN, Han JG. Polysaccharide extraction and biologic activity of different particle size from Tremella fuciformis powder. The 27nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan, 2012. (poster#794)
  • Chiang FM, Lin CY, Huang YL. Effects of water extraction of Grifola frondosa on several cancer cells survival. The 5th China Medical University & Asia University Joint Conference on Biotechnology, Taichung, Taiwan, 2012. (此篇研究榮獲中國醫暨亞洲大學生物技術研討會論文競賽佳作).
  • Huang CY, Huang YL*. Sphingosine 1-phosphate (S1P) inhibits a human prostate cancer PC-3 cell survival via the S1P1- and S1P5-dependent signaling pathway. The 5th China Medical University & Asia University Joint Conference on Biotechnology, Taichung, Taiwan, 2012. (此篇研究榮獲中國醫暨亞洲大學生物技術研討會論文競賽佳作).
  • Wang YM, Huang YL*, Chang HC, Lin CY, Han CK. The Extraction of Polysaccharide of different particle sizes of Tremella fuciformis. The 5th China Medical University & Asia University Joint Conference on Biotechnology, Taichung, Taiwan, 2012. (此篇研究榮獲中國醫暨亞洲大學生物技術研討會論文競賽佳作)
  • Wang YM, Huang YL*, Chang HC, Lin CY, Han CK. Effect of added Tremella fuciformis powder on the hamburger bun baking. The 5th China Medical University & Asia University Joint Conference on Biotechnology, Taichung, Taiwan, 2012.
  • Wang YM, Huang YL*, Chang HC, Lin CY, Han CK. The physical properties of Tremella fuciformis and the hamburger supplemented with Tremella fuciformis. The 5th China Medical University & Asia University Joint Conference on Biotechnology, Taichung, Taiwan, 2012.
  • Wang YM, Huang YL*, Chang HC, Lin CY, Han CK. The extraction of polysaccharide and dietary fiber of different particle sizes of Tremella fuciformis powder. 台灣營養學年會第三十八屆年會暨學術研討會, 台南, 台灣, 2012。
  • Wang YT, Chen YJ, Shih BS, Wang YM, Huang YL, Han CK. The study of polysaccharide extraction from Zizyphus jujube. 台灣營養學年會第三十八屆年會暨學術研討會, 台南, 台灣, 2012。
  • Shih BS, Chen YJ, Wang YT, Wang YM, Huang YL, Han CK. The study of antioxidative capacity from Zizyphus jujube. 台灣營養學年會第三十八屆年會暨學術研討會, 台南, 台灣, 2012。
  • Zeng YR, Chen WS, Lin LW, Han CK, Huang YL*. The anticancer effect of polysaccharides of Grifola frondosa extracted from different extraction methods. 台灣營養學年會第三十八屆年會暨學術研討會, 台南, 台灣, 2012。
  • Chen WS, Lin LW, Han CK, Huang YL*. Different ratio of solute-solvent and extraction time on polysaccharide yield of Grifola frondosa. 台灣營養學年會第三十八屆年會暨學術研討會, 台南, 台灣, 2012。
  • Lin LW, Chen WS, Han CK, Huang YL*. The effects of different solvent and temperature on the yield of polysaccharide extraction from Grifola frondosa powder. 台灣營養學年會第三十八屆年會暨學術研討會, 台南, 台灣, 2012。
  • Chen WS, Lin LW, Huang YL*. Effects of physicochemical properties of hard biscuit supplemented with different particle sizes of Grifola frondosa. The 6th Cross-Strait Symposium on Food, Nutrition and Biotechnology. Hong Kong, 2012.
  • Lin LW, Huang CY, Chen WS, Huang YL*. Changes in texture and physicochemical properties of hard biscuit supplemented with different amounts of Grifola frondosa. The 6th Cross-Strait Symposium on Food, Nutrition and Biotechnology. Hong Kong, 2012.
  • Wang YM, Huang YL*, Chang HC, Lin CY, Han CK. Physicochemical properties of hamburger containing Tremella fuciformis during storage. The 6th Cross-Strait Symposium on Food, Nutrition and Biotechnology. Hong Kong, 2012.
  • Wang YM, Huang YL*, Chang HC, Lin CY, Han CK. Physicochemical properties of hamburger containing Tremella fuciformis during storage. The 6th Cross-Strait Symposium on Food, Nutrition and Biotechnology. Hong Kong, 2012.
  • Zeng YR, Chuang TN, Yang DY, Huang YL*. Studies of anti-cancer and the active components of Tremella fuciformis cultivated from Taiwan and China. The 6th Joint Conference on Biotechnology Asia University and China Medical University, Taichung, Taiwan. 2013.
  • Yang DY, Fan YX, Lin YA, Zeng YR, Huang CY, Huang YL*. The anticancer effect of the fruiting body and primordial of Griforla frondosa. The 27nd Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan. 2013.
  • Lin YC, Wu PY, Lan SY, Huang YL, Lee H. Aryl Hydrocarbon Receptor Inhibits Lysophosphatidic Acid-Induced Vascular Endothelial Growth Factors Expression in Prostate Cancer Cells. Experimental Biology, Boston, USA. 2013.
  • Huang ZY, Ciou YC, Chen CS, Huan WY, Chen JX, Huang YL, Han CK. Antioxidative and Antimicrobial Activities of Garlic and Black Garlic Extracted by Ethanol. International conference and exhibition on nutraceuticals and functional foods, Taipei, Taiwan. 2013.
  • Lin SC, Wu CY, Lin DG, Lin JJ, Huang TT, Chen CH, Su LW, Tsai CH, Huang YL, Han CK. The antioxidant and anticancer effects of Trionyx sinensis in different drying and extraction pretreatments. International conference and exhibition on nutraceuticals and functional foods, Taipei, Taiwan. 2013.
  • Lin DG, Zeng YR, Lin JY, Han CK, Huang YL*. The anticancer and immune-regulation studies of Tremella fuciformis cultivated from Taiwan and China. International conference and exhibition on nutraceuticals and functional foods, Taipei, Taiwan. 2013.
  • Lin YA, Wu MY, Huang CH, Han CJ, Huang YL*. The apoptotic effects of hot water extract of Hibiscus taiwanensis roots on human prostate cancer PC-3 cells. The 7th Joint Conference on Biotechnology Asia University and China Medical University, Taichung, Taiwan. 2014.
  • Lin DG, Yu MY, Lin YA, Wu MY, Huang CH, Huang YL*. Hibiscus taiwanensis induces apoptosis via the mitochondrial- dependent pathway in PC-3 cells. 10th Central European Oncology Congress, Opatija, Croatia. 2014.
  • Lin HY, Yang TY, Lin DG, Lin JY, Han JG, Huang YL*. The white Grifola frondosa suppresses human prostate cancer PC-3 cell survival. 10th Central European Oncology Congress, Opatija, Croatia. 2014.
研究計畫
  • 水解磷酸脂於人類前列腺癌上之研究:細胞自噬、內質網壓力與細胞死亡之調控機制 (亞洲大學校內研究計畫主持人, 100-asia-12)
  • 鞘氨醇1-磷酸鹽於人類前列腺癌上之研究:內質網壓力與細胞自噬之機制探討 (亞洲大學校內研究計畫主持人, 101-asia-38)
  • 大陸與台灣地區銀耳生理活性物質與抗癌機制異同之研究 (國科會大專生研究計畫指導老師, 101-2815-C-468-026-B)
  • 骨細胞之訊息機轉並找尋治療藥物 (中亞聯大研究平台, CMU100-ASIA-00)
  • 山芙蓉萃取液在人類前列腺癌細胞上之研究:抗癌機制與抗藥性探討 (國科會計畫主持人, NSC102-2320-B-468-001)
  • 甲魚萃取物之生理活性與保健效能評估 (允偉興業股份有限公司產學計畫共同主持人)
  • 骨細胞研究平台 (中亞聯大研究平台, CMU101-ASIA-01)
  • 金針菇腳廢棄物生理活性之研究 (亞洲大學校內研究計畫主持人, 102-asia-14)
  • 白舞菇子實體及原基體之抗癌功效評估 (國科會大專生研究計畫指導老師)
  • 骨關節炎研究平台 (中亞聯大研究平台, CMU102-ASIA-10)
  • 以細胞研究平台探討山芙蓉抗動脈粥狀硬化之研究 (科技部計畫主持人, MOST 103-2320-B-468 -003)
專題生
  • 2012 蘇融庭 舞菇的抗癌機制
  • 2012 黃培涵 細胞自噬與前列腺癌的關係
  • 2012 蘇哲民 雄性素對於男性賀爾蒙疾病之探討
  • 2013 曾郁茹 大陸與台灣地區銀耳生理活性與抗癌機制異同之研究
  • 2013 莊采霓 大陸與台灣地區銀耳生理活性及提升免疫調力之研究
  • 2013 林良蔚 不同添加量之舞菇粉對硬質餅乾理化性質之影響
  • 2013 陳宛霞 不同粒徑舞菇粉末添加對硬質餅乾理化性質之研究
  • 2013 楊婕妤 金針菇可食部位及其菇腳對人類前列腺癌PC-3細胞存活之研究
  • 2014 林東谷 甲魚萃取物之抗發炎與抗癌能力分析
  • 2014 楊東盈 白舞菇於人類前列腺癌PC-3細胞存活之研究
  • 2014 黃姿瑜 大蒜生理活性探討及其餅乾加工產品之開發
研究生
  • 2013 黃仲億 鞘氨醇1-磷酸鹽於人類前列腺癌PC-3細胞存活之研究
  • 2013 鄭雨玹 金針菇可食部位及其菇腳生理活性之研究
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