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黃志揚(Chih-Yang Huang) 專任特聘教授兼研發長

黃志揚 (Chih-Yang Huang) 專任特聘教授兼研發長

簡介
黃志揚博士於1987畢業於輔仁大學食營系完成學士學位,同年以榜首進入陽明大學生理所攻讀心臟學內分泌碩士學位,1989年獲陽明大學碩士畢業生最高榮譽伊旬諾論文獎,並於1989年任職39期預官訓實習連長,後轉任營站主任,於1991年完成義務役少尉軍階義務。1992年申請獲五所美國大學博士班研究獎學金,選擇美國伊利諾大學香檳城分子生理所提供之全額獎助學金,加入當時任美國癌症協會副主席(現任美國內分泌主席)Benita. S. Katazenbogen 教授實驗室完成乳癌分子生物學碩士學位。1995年至Dennis E. Buetow 教授實驗室轉攻心臟分子訊息生物學,於1998年獲得伊利諾大學博士學位,並於原實驗室繼續擔任博士後研究員一年。於1999年八月回台,首任職於台中中山醫學大學擔任助理教授一職,於2002年8月升任部定副教授,並於2004年8月兼任創新育成中心主任,2005年10月正式榮升部定教授一職,並於2000-2005間同時擔任國立中正大學分生所兼任教授。2006年8月獲中國醫藥大學聘任教授兼任基礎醫學研究所所長,另於2009年8月同時兼任副研發長一職,2005年迄今同時擔任亞洲大學暨宏光科大兼任教授,2013年迄借調亞洲大學生科系特聘教授兼研發處研發長,2016年並兼任國際及兩岸教育學院院長。目前研究主題包含探討類胰島素生長因子接受體(IGF-IR)調控心肌細胞存活及IGF-IIR誘發心肌細胞凋亡機轉探討,並研究女性雌激素及其受體之心肌保護機轉,同時進行多種癌症抑制,神經再生及中醫藥之研究。目前主持(含共同)多件國科會計畫,及校內外合作計劃,同時擔任國科會計畫初審及覆審委員,考選部高考出題及審題委員,衛生福利部食品藥物管理署[健康食品審議小組] 審議委員,中醫大亞洲醫學雜誌及BioMedicine副主編,中國生理學雜誌(SCI),調適醫學雜誌,World Journal of Oncology, World Journal of Moleucular Biology等編輯委員,中國生理學會第23屆理事及調適醫學會第1&2屆理事。至2017年共發表SCI –papers (>400篇)。
學歷
台灣 陽明大學生理所 心臟內分泌學 碩士(1987-1989)
美國 伊利諾大學香檳校區 分子生理所 乳癌分子醫學 碩士(1992-1995)
美國 伊利諾大學香檳校區 分子生理所 心臟分子醫學 博士(1995-1998)
美國 伊利諾大學香檳校區 分子生理所 心臟分子醫學 博士後研究(1998-1999)
現職
亞洲大學生科系 特聘教授兼研發處研發長
中國醫藥大學生醫所專任/中醫所合聘教授
中國附醫醫學研究部及生醫工程研究中心(顧問)
中國醫藥大學暨附設醫院 桂冠研究人才計畫主持人
越南國立孫德勝大學兼任特聘教授及台灣弘光科技大學營養醫學所兼任教授
中醫大BioMedicine醫學雜誌副總編輯/中國生理學雜誌(CJP, SCI)及調適醫學雜誌編輯
中國生理學會第23屆理事/調適醫學會第1&2屆理事/台灣內分泌代謝學會監事
生技類核心設施平台維運計畫 基因轉殖鼠核心設施使用者委員會委員
Serving as Associate Edotor in Pharmacologia of Science Alert(2018)
Membership in the Asian Council of Science Editors(2018)
經歷
台灣 陽明大學 生理學兼任助教(1987-1989)
台灣39期義務役預官(醫勤官兼營站主任)(1989-1991)
美國 伊利諾大學香檳校區 分子生理所助理及助教(1992-1996&1996-1998)
台灣中正大學 分子生物研究所 兼任教授(2000-2008)
中山醫學大學 生化暨生物科技研究所 助教授(1999.8-2002.7)
中山醫學大學 生化暨生物科技研究所 副教授(2002.8-2005.10)
中山醫學大學 生化暨生物科技研究所 教授(2005.10-2006.7)
中山醫學大學 創新育成中心 主任(2005.8-2006.7)
中國醫藥大學 基礎醫學研究所所長(2006.11-2013.1)兼副研發長(2009.8-2013.1)
中國生理學雜誌(CJP, SCI)暨中醫大中台灣醫學雜誌副總編輯(2009.8-2013.1)
國科會生物處專題研究計畫初/複審委員及考選部高考出題/審題委員
衛生福利部食品藥物管理署[健康食品審議小組] 審議委員
分機
學校: 04-22053366#(O)3313 (L)3315, 3316
醫院: 04-22052121#(O)7716, 7701 (L)7707
亞大: 04-23323456#(O)6140
研究領域
心臟分子生化及癌症分子醫學
雌性素(Estrogen)及其受體基因轉殖在心血管疾病阻斷及肝癌,直腸癌,口腔癌,前列腺癌防治機轉探討。癌症幹細胞移除機制研究。
心肌細胞中鈣離子調控之激脢,去磷酸根脢及細胞激素之角色。
心肌細胞肥厚及猝死之起始因子(含生長因子,發炎等)及臨床診斷指標(Clinicalbiochemical markers)尋找。
IGF-I及IGF-II在心肌細胞之交互調控角色探討。
醣尿病患及動物併發心血管疾病過程中其機轉及臨床診斷指標探討。
DNA基因晶片在各種心肌疾病及肝癌,直腸癌的應用。
心肌細胞肥厚過程中,Cytochrome-c-oxidase活性及基因表現的差異。
針灸的降血壓及抑心肌肥大分子機轉探討。
強心促肝及神經細胞再生中藥材複方篩選及其單一成分調控之分子迅息探討,並分析其與西藥之混合療效。中草藥抗心肌肥厚及心肌凋亡療效評估及機轉探討。
運動介入對血酯肪所誘導之心肌細胞肥厚拮抗作用及先天基因性肥胖鼠(Zucker)心肌病變分子迅息機轉研究。
低氧低壓的心肌傷害及心肌細胞適應之分子機轉及鐵離子之氧化傷害評估。
臨床心室中隔缺損病患及手術前後心肌組織之基因表現差異及梗塞組織之基因SNP掃瞄。
Translational Study of 負電性低密度脂蛋(L5)-Mediated Diabetic Cardiomyopathy。
SDF-1/CXCR4調控MMP2/9訊息在血管內皮幹細胞(hUCB34-EPCs)引導中風血管新生過程之機轉探討。
Rejuvenating the aging brain by modulating NMDA-glycine receptor activity: genetic manipulation
教師歷程檔案
期刊論文
  • Wu DJ, Lin JA, Chiu YT, Cheng CC, Shyu CL, Chih-Yang Huang, Ueng KC,Pathological and biochemical analysis of dilated cardiomyopathy of broiler chickens. Chin J Physiol. 2003 Mar 31;46(1):19-26. (Correspondence Author)
  • Wu HC, Lin JG, Chu CH, Chang YH, Chang CG, Hsieh CL, Tsai AH, Ueng KC, Kuo WW, Lin JA, Liu JY, Chih-Yang Huang, The effects of acupuncture on cardiac muscle cells and blood Pressure in spontaneous hypertensive rats. Acupunct Electrother Res. 2004;29(1-2):83-95. (Correspondence Author)
  • Cheng TC, Huang CC, Chen CI, Liu CH, Hsieh YS, Chih-Yang Huang, Lee MS, Liu JY.Leukemia Inhibitory Factor Antisense Oligonucleotide Inhibits the Development of Murine Embryos at Pre-Implantation Stages. Biol Reprod. 2004 May;70(5):1270-6.
  • Kuo WW, Chu CY, Wu CH, Lin JA, Liu JY, Ying TH, Lee SD, Hsieh YH, Chu CH, Lin DY, Hsu HH, Chih-Yang Huang .The profile of cardiac cytochrome c oxidase (COX) expression in an accelerated cardiac hypertrophy model in rats. J Biomed Sci. 2005;12(4):601-10. (Correspondence Author)
  • Chih-Yang Huang ,Chen JH, Tsai CH, Kuo WW, Liu JY, Chang YC. Regulation of extracellular signal-regulated protein kinase signaling in human osteosarcoma cells stimulated with nicotine. J Periodontal Res. 2005 Apr;40(2):176-81. (First Author)
  • Lin TB, Lo MJ, Chih-Yang Huang, Ting H, Lee SD.GABAergic modulation of ventilatory response to acute and sustained hypoxia in obese Zucker rats. Int J Obes (Lond). 2005 Feb;29(2):188-95.
  • Kuo WW, Chu CY, Wu CH, Lin JA, Liu JY, Ying TH, Lee SD, Hsieh YH, Chu CH, Lin DY, Hsu HH, Chih-Yang Huang,The profile of cardiac cytochrome c oxidase (COX) expression in an accelerated cardiac-hypertrophy model. J Biomed Sci. 2005;12(4):601-10. (Co-Correspondence Author)
  • Tsai JH, Tsai MT, Su WW, Chen YL, Wu TT, Hsieh YS, Chih-Yang Huang, Yeh KT, Liu JY. Expression of protein kinase C alpha in biopsies and surgical specimens of human hepatocellular carcinoma. Chin J Physiol. 2005 Sep 30;48(3):139-43.
  • Kuo WW, Chu CY, Wu CH, Lin JA, Liu JY, Hsieh YH, Ueng KC, Lee SD, Hsieh DJ, Hsu HH, Chen LM, Chih-Yang Huang, Impaired IGF-I signaling of hypertrophic hearts in the development phase of hypertension in genetically hypertensive rats. Cell Biochem Funct. 2005 Sep-Oct;23(5):325-31. (Correspondence Author)
  • Kuo WW, Wu CH, Lee SD, Lin JA, Chu CY, Hwang JM, Ueng KC, Chang MH, Yeh YL, Wang CJ, Liu JY, Chih-Yang Huang,Second-Hand Smoke–Induced Cardiac Fibrosis Is Related to the Fas Death Receptor Apoptotic Pathway without Mitochondria-Dependent Pathway Involvement in Rats. Environ Health Perspect. 2005 Oct;113(10):1349-53. (Correspondence Author)
  • Huang EJ, Kuo WW, Chen YJ, Chen TH, Chang MH, Lu MC, Tzang BS, Hsu HH, Chih-Yang Huang, Lee SD.Homocysteine and other biochemical parameters in type 2 diabetes with different diabetic duration or diabetic retinopathy. Clin Chim Acta. 2006 Apr;366(1-2):293-8 (Co-Correspondence Author)
  • Lee SD, Chih-Yang Huang, Shu WT, Chen TH, Lin JA, Hsu HH, Lin CS, Liu CJ, Kuo WW, Chen LM. Pro-inflammatory states and IGF-I level in ischemic heart disease with low or high serum iron. Clin Chim Acta. 2006 Aug;370(1-2):50-6.
  • Lee SD, Kuo WW, Wu CH, Lin YM, Lin JA, Lu MC, Yang AL, Liu JY, Wang SG, Liu CJ, Chen LM, Chih-Yang Huang .Effects of short-term and long-term Hypobaric Hypoxia on Bcl2 family in rat heart. Int J Cardiol. 2006 Apr 14;108(3):376-84. (Correspondence Author)
  • Huang EJ, Wu CC, Lee SD, Chen JH, Liu JY, Ko JL, Lin JA, Lu MC, Chen LM, Chih-Yang Huang, Kuo WW.Opposing action of estrogen receptors α and β on tumor necrosis factor-α gene expression and Caspase-8-mediated apoptotic effects in HA22T cells. Mol Cell Biochem. 2006 Jul;287(1-2):137-45.
  • Huang EJ, Wu CC, Huang HP, Liu JY, Lin CS, Chang YZ, Lin JA, Lin JG, Chen LM, Lee SD, Kuo WW , Chih-Yang Huang .Apoptotic and anti-proliferative effects of estrogen and estrogen-like compounds in the Hep3B cell line. Mol Cell Biochem. 2006 Oct;290(1-2):1-7. (Correspondence Author)
  • Hsieh YH, Wu TT, Tsai JH, Chih-Yang Huang, Hsieh YS, Liu JY.PKCα expression regulated by Elk-1 and MZF-1 in human HCC cells. Biochem Biophys Res Commun. 2006 Jan 6;339(1):217-25.
  • Lee SD, Wu CC, Kuo WW, Lin JA, Hwang JM, Lu MC, Chen LM, Hsu HH, Wang CK, Chang SH Chih-Yang Huang .Porphyromonas gingivalis-related cardiac cell apoptosis was majorly co-activated by p38 and extracellular signal-regulated kinase pathways. J Periodontal Res. 2006 Feb;41(1):39-46. (Correspondence Author)
  • Lee SD, Chen LM, Kuo WW, Shu WT, Kuo WH, Huang EJ, Tsai CC, Li PC, Liu JY, Chen TH, Chih-Yang Huang Serum Interleukin-10, Insulin-like growth factor-axis and MMPs in the patients with rheumatic heart disease and acute rhematoid arthritis. Clin Chim Acta. 2006 May;367(1-2):62-8. (Correspondence Author)
  • Lee SD, Kuo WW, Lin DY, Chen TH, Kuo WH, Hsu HH, Chen JZ, Liu JY, Yeh YL Chih-Yang Huang Role of calcineurin in Porphyromonas gingivalis-induced myocardial cell hypertrophy and apoptosis. J Biomed Sci. 2006 Mar;13(2):251-60. (Correspondence Author)
  • Jong GP, Ma T, Chou P, Chang MH, Wu CH, Lis PC, Lee SD, Liu JY, Kuo WW, Chih-Yang Huang ,Serum MMP-9 Activity as a Diagnosing Marker for the Developing Heart Failure of Post MI Patients. Chin J Physiol. 2006 Apr 30;49(2):104-9. (Correspondence Author)
  • Lee SD, Chang SH, Kuo WH, Ying TH, Kuo WW, Li PC, Hsu HH, Lu MC, Ting H, Chih-Yang Huang,Role of MEK in Porphyromonas gingivalis-induced myocardial cell hypertrophy and apoptosis. Eur J Oral Sci.2006 Apr;114(2):154-9 (Correspondence Author)
  • Lee SD, Wu CC, Chang YC, Chang SH, Wu CH, Wu JP, Hwang JM, Kuo WW, Liu JY, Chih-Yang Huang Porphyromonas gingivalis-induced cellular hypertrophy and MMP-9 activity via different signaling pathways in H9c2 cardiomyoblast cells. J Periodontol. 2006 Apr;77(4):684-91. (Correspondence Author)
  • Hsu HH, Cheng SF, Wu CC, Chu CH, Weng YJ, Lin CS, Lee SD, Wu HC, Chih-Yang Huang, Kuo WW.Apoptotic effects of over-expressed estrogen receptor-β on LoVo colon cancer cell is mediated by p53 signalings in a ligand-dependent manner. Chin J Physiol. 2006 Apr 30;49(2):110-6. (Co-Correspondence Author)
  • Kuo WW, Liu CJ, Chen LM, Wu CH, Chu CH, Liu JY, Lu MC, Lin JA, Lee SD, Chih-Yang Huang.Cardiomyocyte apoptosis induced by insulin-like growth factor (IGF)-I resistance is IGF-II dependent and synergistically enhanced by angiotensin II. Apoptosis. 2006 Jul;11(7):1075-89. (Co-Correspondence Author)
  • Lee SD, Chu CH, Huang EJ, Lu MC, Liu JY, Liu CJ, Hsu HH, Lin JA, Kuo WW, Chih-Yang Huang.Role of insulin-like growth factor-II in cardiomyoblast apotosis and in hypertensive rat heart with abdominal aorta ligation. Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E306-14. (Correspondence Author)
  • Huang EJ, Wu CC, Huang HP, Liu JY, Lin CS, Chang YZ, Lin JA, Lin JG, Chen LM, Lee SD, Kuo WW, Chih-Yang Huang.Apoptotic and anti-proliferative effects of 17β-estradiol and 17β- estradiol -like compounds in the Hep3B cell line. Mol Cell Biochem. 2006 Oct;290(1-2):1-7. (Correspondence Author)
  • Hsu HH, Cheng SF, Chen LM, Liu JY, Chu CH, Weng YJ, Li ZY, Lin CS, Lee SD, Kuo WW, Chih-Yang Huang. Over-expressed estrogen receptor-alpha up-regulates hTNF-alpha gene expression and down-regulates β-catenin signaling activity to induce the apoptosis and inhibit proliferation of LoVo colon cancer cells. Mol Cell Biochem. 2006 Sep;289(1-2):101-9. (Co-Correspondence Author)
  • Hsu TC, Chiang SY, Chih-Yang Huang, Tsay GJ, Yang CW, Huang CN, Tzang BS.Beneficial effects of treatment with transglutaminase inhibitor cystamine on macrophage response in NZB/W F1 mice. Exp Biol Med (Maywood). 2007 Feb;232(2):195-203.
  • Hsieh YH, Wu TT, Chih-Yang Huang, Hsieh YS, Hwang JM, Liu JY. p38 mitogen-activated protein kinase pathway is involved in protein kinase Calpha-regulated invasion in human hepatocellular carcinoma cells. Cancer Res. 2007 May 1;67(9):4320-7.
  • Chen LM, Kuo WW, Yang JJ, Wang SG, Yeh YL, Tsai FJ, Ho YJ, Chang MH, Chih-Yang Huang, Lee SD. Eccentric Cardiac Hypertrophy was Induced by Long-term Intermittent Hypoxia in rats. Exp Physiol. 2007 Mar;92(2):409-16. (Co-Correspondence Author)
  • Hsieh YH, Wu TT, Chih-Yang Huang, Hsieh YS, Liu JY.Antisense Suppression of Tumorigenicity of Human Hepatocellular Carcinoma Cells by Antisense Oligonucleotide MZF-1. Chin J Physiol. 2007 Feb 28;50(1):9-15.
  • Chang MH, Kuo WW, Li PC, Lin DY, Lee SD, Tsai FJ, Jong GP, Lin YM, Chih-Yang Huang, Wu WJ.Down regulation of IGF-I and IGF-IR gene expression in cardiac tissue of infants with isolated ventricular septal defect. Clin Chim Acta. 2007 Apr;379(1-2):81-6. (Co-Correspondence Author)
  • Lee SD, Kuo WW, Lin JA, Chu YF, Wang CK, Yeh YL, Wang SG, Liu JY, Chang MH, Chih-Yang Huang Effects of long-term intermittent hypoxia on mitochondrial and Fas death receptor dependent apoptotic pathways in rat hearts. Int J Cardiol. 2007 Apr 4;116(3):348-56. (Correspondence Author)
  • Wu MK, Wang CK, Bai YM, Chih-Yang Huang, Lee SD. Outcomes of obese, clozapine-treated inpatients with schizophrenia placed on a six-month diet and physical activity program. Psychiatr Serv. 2007 Apr;58(4):544-50.
  • Hsieh YH, Wu TT, Chih-Yang Huang, Hsieh YS, Hwang JM, Liu JY. p38 MAPK Pathway Is Involved in Protein Kinase Cα-Regulated Invasion in Human Hepatocellular Carcinoma Cells. Cancer Res. 2007 May 1;67(9):4320-7.
  • Wu TT, Hsieh YH, Wu CC, Hsieh YS, Chih-Yang Huang, Liu JY.Overexpression of protein kinase Cα mRNA in human hepatocellular carcinoma: a potential marker of disease prognosis. Clin Chim Acta. 2007 Jul;382(1-2):54-8.
  • Yang AL, Lo MJ, Ting H, Chen JS, Chih-Yang Huang, Lee SD.GABAA and GABAB receptors differentially modulate volume and frequency in ventilatory compensation in obese Zucker rats. J Appl Physiol. 2007 Jan;102(1):350-7 (Co-Correspondence Author)
  • Min-Chi Lu, Bor-Show Tzang,Wei-Wen Kuo,Fong-Li Wu, Yueh-Sheng Chen, Chang-Hai Tsai, Chih-Yang Huang,Shin-Da Lee. More Activated Cardiac Mitochondrial-dependent Apoptotic Pathway in Obese Zucker Rats. Obesity (Silver Spring). 2007 Nov;15(11):2634-42. (Co-Correspondence Author)
  • Gwo-Ping Jong, Yuh-Feng Wang , Fuu-Jen Tsai, Chang-Hai Tsai, Ching-Lin Wu, Rosa Huang Liu, Dennis Jine-Yuan Hsieh, Fu-Yang Ko, Chih-Yang Huang, Shin-Da Lee. Immunoglobulin E and Matrix Metalloproteinase-9 in patients with different stages of coronary artery disease. Chinese Journal of Physiology 2007 50(6): 277-282 (Co-Correspondence Author)
  • Da-Tian Bau, Ming-Hsui Tsai, Chih-Yang Huang, Cheng-Chun Lee,Relationship between, Hsien-Chang Tseng, Yen-Li Lo, Yuhsin Tsai, Fuu-Jen Tsai.Polymorphisms of Nucleotide Excision Repair Genes and Oral Cancer Risk in Taiwan: Evidence for Modification of Smoking Habit. Chinese Journal of Physiology 2007 50(6): 294-300
  • Yi-Hsien Hsieh, Trang-Tiau Wu, Chih-Yang Huang, Yih-Shou Hsieh, Jer-Yuh Liu. Suppression of tumorigenicity of human hepatocellular carcinoma cells by antisense oligonucleotide MZF-1. Chinese Journal of Physiology 200750(1): 9-15
  • Jin-Ming Hwang, Yi-Jiun Weng, Yueh-Min Lin, Da-Tian Bau, Fu-Yang Ko, Fuu-Jen Tsai, Chieh-Hsi Wu, Pei-Cheng Lin*, Chih-Yang Huang*, Wei-Wen Kuo* Hypoxia-induced compensatory effect as related to Shh and HIF-1α in ischemia embryo rat heart. Moelcular and cellular Biochemistry. 2008, 311(1-2):179-187 (Co-Correspondence Author)
  • Hui-Man Cheng, Chien-Yun Hsiang, Guang-Wei Chen, Shih-Lu Wu, Jaw-Chyun Chen, Chih-Yang Huang, Da-Tian Bau, Tin-Yun Ho. LPS-Induced Interleukin-1α and TNF-α Production is inhibited by Menthone through NF-kB signaling Pathway in HaCat Cells. Chinese Journal of Physiology, 2008.51(4):1-7.
  • Chung-Jung Liu, Jin-Ming Hwang, Trang-Tiau Wu, Yi-Hsien Hsieh, Cheng-Chung Wu, Yih-Shou Hsieh, Chang-Hai Tsai, Hsi-Chin Wu, Chih-Yang Huang*, and Jer-Yuh Liu*. Anion Exchanger Inhibitor DIDS Induces Human Higher Maligant Hepatoccellular Carcinoma HA22T Cell Apoptosis. Moelcular and cellular Biochemistry. 2008,308(1-2):117-125 (Co-Correspondence Author)
  • Yueh-Min Lin, Shu-Kuei Huang, Hsueh Fang Wang, Li-Mien Chen, Fuu-Jen Tsai, Hsi-Hsien Hsu, Chia-Hua Kuo, Shyi-Gang P. Wang, Chih-Yang Huang*, Shin-Da Lee*. Short-Term versus Long-Term Intermittent Hypobaric Hypoxia on Cardiac fibrosis and Fas-Death-Receptor Dependent Apoptotic Pathway in Rat Hearts (Chinese Journal of Physiology, 2008, 51(5):308-316 *(Co-Correspondence Author)
  • Mei-Kuei Wu, Chih-Yang Huang, Ying Jay Liou, Chin-Kun Wang, Shin-Da Lee. Glucose-insulin homeostasis, lipid profiles and GH-IGF-IGFBP axis in clozapine-treated schizophrenic obesity versus non-psychiatric obesity. (International Journal of Obesity, 2008, 32(3):436-42.
  • Hsi-Chin Wu, Yu-Lan Yeh, Wei-Wen Kuo, Shu-Kuei Huang, Wu-Hsien Kuo, Dennis Jine-Yuan Hsieh, Ching-Lin Wu, Chang-Hai Tsai, Shin-Da Lee*, Chih-Yang Huang*. P38 mitogen-activated protein kinase pathways are involved in the hypertrophy and apoptosis of cardiomyocytes induced by Porphyromonas gingivalis conditioned medium (Cell Biochemistry and Function, 2008, 26(2):246-255 (Correspondence Author)
  • Hsu TC, Chih-Yang Huang, Chiang SY, Lai WX, Tsai CH, Tzang BS. Transglutaminase inhibitor cystamine alleviates the abnormality in liver from NZB/W F1 mice. Eur J Pharmacol. 2008,579(1-3):382-389
  • Tsai-Ching Hsu, Ji-Qiang Gao, Ko-Hsiu Lu, Chang-Hai Tsai, Chih-Yang Huang*, Bor-Show Tzang*. Japanese Encephalitis Virus Envelope Protein Mitigates TNF-α mRNA Expression in RAW264.7 Cells Inflammation, 2008,31(2),133-140 (Co-correspondence Author)
  • Te-Chi Liu, Yung-Yang Liu, Shin-Dd Lee, Chih-Yang Huang, Kuei-Yu Chien, I-Shiung Cheng, Chih-Yuan Lin, Chia-Hua Kuo, Effects of short-term detraining on measures of obesity and glucose tolerance in elite athletes. Journal of Sports Sciences, 2008; 26(9): 919-925
  • Wei-Wen Kuo, Chung-Jung Liu, Chun-Hsien Chu, Yi-Jiun Weng, May-Hua Jen, Ming-Chin Lu, Fuu-Jen Tsai, Chang-Hai Tsai and Chih-Yang Huang* A Phonex Arising From Fire: New Application of Old Traditional herbs, Chapter 6: Traditional Chinese Medicine on Protection of Heart Function and Cardiovascular System. Research Signpost, 2008, (Correspondence Author)
  • Tsai, J.H., Liu, J.Y., Wu, T.T., Ho, P.C., Chih-Yang Huang, Shyu, J.C., Hsieh, Y.S., Tsai, C.C., and Liu Y.C. Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats. Journal of Viral Hepatitis, , 2008. Jul;15(7):508-14
  • Chun-Hsien Chu, Bor-Show Tzang, Li-Mien Chen, Chia-Hua Kuo, Yi-Chang Cheng, Ling-Yun Chen, Fuu-Jen Tsai, Chang-Hai Tsai, Wei-Wen Kuo*, Chih-Yang Huang* IGF-II receptor signaling induced cell hypertrophy and ANP/BNP expression via Gαq interaction and PKCα/ CaMKII activation in the H9c2 cardiomyoblast cells. (Journal of Endocrinology, 2008, 197(2),381-390 ) (Correspondence Author)
  • Wen-Yuan Lin, Tai-Yuan Chiu, Long-Teng Lee, Cheng-Chieh Lin, Chih-Yang Huang and Kuo-Chin Huang. Betel nut chewing is associated with increased risk of cardiovascular disease and all-cause mortality in Taiwanese men. American Journal of Clinical Nutrition, 2008,87(5), 1204-1211.
  • Chang MH, Kuo WW, Chen RJ, Lu MC, Tsai FJ, Kuo WH, Chen LY, Wu WJ, Chih-Yang Huang *, Chu CH. IGF-II/mannose 6-phosphate receptor activation induces metalloproteinase-9 matrix activity and increases plasminogen activator expression in H9c2 cardiomyoblast cells. J Mol Endocrinol. 2008 41(2):65-74 (Co-correspondence Author)
  • Chung-Jung Liu,Yi-Chang Cheng,Kung-Wei Lee,Hsi-Hsien Hsu,Chun-Hsien Chu, Fuu-Jen Tsai, Chang-Hai Tsai, Chia-Yih Chu, Jer-Yuh Liu, Wei-Wen Kuo and Chih-Yang Huang* Lipopolysaccharide induces cellular hypertrophy through calcineurin/NFAT-3 signaling pathway in H9c2 myocardiac cells. Mol Cell Biochem.2008;313(1-2):167-78. *(Correspondence Author)
  • Chun-Hsien Chu*, Chih-Yang Huang*, Ming-Chin Lu, James A. Lin, Fuu-Jen Tsai, Chang-Hai Tsai, Chia-Yih Chu, Wu-Hsien Kuo, Li-Mien Chen, Ling-Yun Chen IGF-II Synergistically Enhances AG1024-induced H9c2 Cardiomyoblast Cell Apoptosis via the Interaction of IGF2R with Gα Proteins and Its Downstream PKA and PLC-β Modulators. (Chinese Journal of Physiology, 2008, Feb 28;52(1):31-7.(Co-First Author)
  • Shin-Da Lee, Wei-Wen Kuo, Ying-Jui Ho, Ann-Chi Lin, Chang-Hai Tsai, Hsueh Fang Wang, Chia-Hua Kuo, Ai-Lun Yang*, Chih-Yang Huang*, Jin-Ming Hwang* Cardiac Fas-dependent and mitochondria-dependent apoptosis in ovariectomized rat.2008 61(3):268-277 *(Co-correspondence Author)
  • Yi-Chang Cheng, Wei-Wen Kuo, Chieh-Hsi Wu, Wen-Tong Shu, Chia-Hua Kuo, Jin-Ming Hwang, Hsi-Hsien Hsu, Li-Ming Chen#, Chih-Yang Huang #, Shin-Da Lee PhD# Iron status and cardiovascular risk factors in patients with hemodialysis versus patients with ischemic heart disease. Nephrology. 2008 , Feb;14(1):65-9 (Co-correspondence Author)
  • Tsai-Ching Hsu, Szu-Yi Chiang, Jen-Huang Wu, Chun-Chou Tsai, Chih-Yang Huang,Yi-Chen Chen, Bor-Show Tzang. Treatment with Taurine Attenuates Hepatic Apoptosis in NZB/W F1 Mice Fed with a High-Cholesterol Diet. J. Agric. Food Chem. September 25, 2008 56(20):9685-9691. (Co-correspondence Author)
  • Tsai-Ching Hsu, Yi-Chen Chen, Wen-Xian Lai, Szu-Yi Chiang, Chih-Yang Huang*, Bor-Show Tzang*. Beneficial effects of treatment with cystamine on brain in NZB/W F1 mice. European Journal of Pharmacology 2008,591:307-314 (Co-correspondence Author)
  • Tseng HC, Tsai MH, Chiu CF, Wang CH, Chang NW, Chih-Yang Huang, Tsai CW, Liang SY, Wang CL, Bau DT Association of XRCC4 codon 247 polymorphism with oral cancer susceptibility in Taiwan. Anticancer Res. 2008; 28(3A):1687-91.
  • Chiou, S.H., C.C. Yu, Chih-Yang Huang, S.C. Lin, C.J. Liu, T.H. Tsai, S.H. Chou, C.S. Chien, H.H. Ku, J.F. Lo. Positive Correlations of Oct-4 and Nanog in Oral Cancer Stem-Like Cells and High Grade Oral Squamous Cell Carcinoma. Clinical Cancer Research. 2008. Jul 1;14(13):4085-95.
  • Shin-Da Lee, Wei-Wen Kuo, Da-Tian Bau, Fu-Yang Ko, Fong-Li Wu, Chia-Hua Kuo, Jin-Ming Hwang, Shyi-Gang P. Wang, Min-Chi Lu*, Chih-Yang Huang*. The coexistence of intermittent hypoxia and obesity additively increase cardiac apoptosis (Journal of Applied Physiology, 2008, Apr;104(4):1144-53 (Correspondence Author)
  • Tsai-Ching Hsu, Joung-Liang Lan, Shao-Hsuan Kao, Yin-Chang Liu#, Chih-Yang Huang*, Bor-Show Tzang#* Character of Autoantibody against Proliferating Cell Nuclear Antigen from a Patient with Systemic Lupus Erythematosus The Chinese Journal of Physiology 2009 Feb;79(2):209-14. (co-correspondence Author)
  • Chi-Chang Huang, Tien-Jen Lin, Yi-Fa Lu, Chun-Chieh Chen, Chih-Yang Huang*, Wan-Teng Lin* Protective Effects of L-Arginine Supplementation Against Exhaustive Exercise-Induced Oxidative Stress in Young Rat Tissue (Chinese Journal of Physiology, 2009, 31;52(5):306-15. (Co-Correspondence Author)
  • Lin WT, Huang CC, Lin TJ, Chen JR, Shieh MJ, Peng HC, Yang SC, Chih-Yang Huang *. Effects of beta-carotene on antioxidant status in rats with chronic alcohol consumption. Cell Biochem Funct. 2009 Jul 27. (correspondence Author)
  • Wei-Wen Kuo, Chih-Yang Huang, Jing-Gung Chung, Shun-Fa Yang , Kun-Ling Tsai, Tsan-Hung Chiu, Shin-Da Lee *, Hsiu-Chung Ou*. Crude Extracts of Solanum lyratum Protect Endothelial Cells Against Oxidized Low-Density Lipoprotein-Induced Injury Via Direct Antioxidant Action. Journal of Vascular Surgery 2009 50(4):849-60
  • Chih-Yang Huang, Tsai-Ching Hsu, Wu-Hsien Kuo, Shih-Ping Wu, Yueh-Min Lin, Chun-Yu Yen, Jen-Huang Wu, Bor-Show Tzang. Beneficial Effects of Taurine on Cardiac Abnormality in NZB/W F1 Mice Fed with a High-Cholesterol Diet Journal of Agricultural and Food Chemistry 2009 23;57(18):8635-42. (First Author)
  • Wen-Kuei Fang, Fu-Yang Ko, Hwai Lee Wang, Ming-Chin Lu, Li-Ming Chen, Fuu-Jen Tsai, Chang-Hai Tsai, Yueh-Sheng Chen, Wei-Wen Kuo, Chih-Yang Huang. The Proliferate and Migrate Effects of Huangqi On RSC96 Schwann Cells. American J. of Chinese Medicine .2009 37(5):945-59. (Correspondence Author)
  • Kun Shan Huang , Min-Jin Lu, Yueh-Sheng Chen, Fuu-Jen Tsai, Wei-Wen Kuo, Yi-Chang Cheng, Chien-Chung Lin, Chang-Hai Tsai, Chih-Yang Huang*, Jaung-Geng Lin*, Hsiu-Chung Ou*. Proliferative effects of chishao on Schwann cells are FGF-uPA, and ERK- and JNK-dependent. American J. of Chinese Medicine .2009 37(6):1191-202. (co-Correspondence Author)
  • Ming-Chin Lu, Tung-Yuan Lai, Jin-Ming Hwang, Hsien-Te Chen3 Sheng-Huang Chang, Fuu-Jen Tsai, Hwai-Lee Wang, Chien-Chung Lin*, Wei-Wen Kuo*, Chih-Yang Huang* Proliferation- and migration- enhancing effects of Ginseng and Ginsenoside Rg1 through IGF-I- and FGF-2-signaling pathways on RSC96 Schwann Cells (Cell Biochemistry and Function, 2009, 27(4):186-92 (Correspondence Author)
  • Chen CH, Liu YF, Lee SD, Chih-Yang Huang, Lee WC, Tsai YL, Hou CW, Chan YS, Kuo CH. Altitude hypoxia increases glucose uptake in human heart. High Alt Med Biol. 2009 Spring;10(1):83-6.
  • Chun-Hsien Chu*, Chih-Yang Huang*, Ming-Chin Lu*, James A. Lin, Fuu-Jen Tsai, Chang-Hai Tsai, Chia-Yih Chu, Wu-Hsien Kuo, Li-Mien Chen,and Ling-Yun Chen. Enhancement of AG1024-Induced H9c2 Cardiomyoblast Cell Apoptosis via the Interaction of IGF2R with Gα Proteins and Its Downstream PKA and PLC-β Modulators by 1GF-II. Chinese Journal of Physiology, 2009. 52(1): 1-7 (co-First Author)
  • Wei-Wen Kuo, Min-Jin Lu, Cheng-Tzu Liu, Shih-Ping Wu, Chia-Hua Kuo, Fuu-Jen Tsai, Chang-Hai Tsai, Hung-Chien Wu*, Chih-Yang Huang,Shin-Da Lee*. Effects of insulin replacement on cardiac apoptotic and survival pathways in streptozotocin-induced diabetic rats Cell Biochemistry and Function 2009 27(7):479-87. (co-correspondence Author)
  • Chen YL, Chih-Yang Huang, Lee SD, Chou SW, Hsieh PS, Hsieh CC, Huang YG, Kuo CH. Discipline-specific insulin sensitivity in athletes. Nutrition. 2009 Jul. 25(11-12):1137-42.
  • Wang JS, Chen SM, Lee SP, Lee SD, Chih-Yang Huang, Hsieh CC, Kuo CH. Dehydroepiandrosterone Sulfate Linked to Physiologic Response against Hot Spring Immersion.Steroids. 2009 Jul 9. 74(12):945-9.
  • Yung-Ming Chang, Ying-Ting Shih, Yueh-Sheng Chen, Chien-Liang Liu, Wen-Kuei Fang, Chang-Hai Tsai, Fuu-Jen Tsai, Wei-Wen Kuo*, Tung-Yuan Lai*, Chih-Yang Huang* Earthworm (Pheretima aspergilum) extracts to induce the Schwann cell migration activate PAs and MMP2/9 mediated through ERK1/2 and p38 signalings. ECAM Journal, 2009 Oct 31;52(5):306-15. (Correspondence Author)
  • Lin WY, Pi-Sunyer FX, Liu CS, Li TC, Li CI, Chih-Yang Huang, Lin CC. Betel nut chewing is strongly associated with general and central obesity in Chinese male middle-aged adults. Obesity (Silver Spring). 2009 Jun;17(6):1247-54.
  • Kun-Shan Huang, Jaung-Geng Lin, Han-Chung Lee, Fuu-Jen Tsai, Da-Tian Bau, Chih-Yang Huang*, Chun-Hsu Yao, Yueh-Sheng Chen Paeoniae alba Radix promotes peripheral nerve regeneration. Evidence Based Complementary and Alternative Medicine 2009 2011:109809. (co-correspondence Author)
  • Yi-Chang Cheng, Wei-Wen Kuo, Hsi-Chin Wu, Tung-Yuan Lai, Jin-Ming Hwang, Wen-Hung Wang, Fuu-Jen Tsai, Jaw-Ji Yang*, Chih-Yang Huang*, Chun-Hsien Chu* ZAK induces MMP-2 activity via JNK/ p38 signals and reduces MMP-9 activity by increasing TIMP-1/2 expression in H9c2 cardiomyoblast cells. Mol Cell Biochem.2009 May;325(1-2):69-77 (co-Correspondence Author)
  • Yi-Chang Cheng, Li-Mien Chen, Mu-Hsin Chang, Wei-Kung, Chen, Fuu-Jen Tsai, Chang-Hai Tsai, Yi-Chang Cheng, Wei-Wen Kuo* and Chih-Yang Huang*, Chung-Jung Liu* Lipopolysaccharide-Upregulated uPA, MMP-2 and MMP-9 via ERK1/2 signaling in H9c2 Cardiomyoblast Cells. Mol Cell Biochem. 2009 325(1-2):15-23. (co-Correspondence Author)
  • Chih-Yang Huang, Li-Chiu Yang, Kuan-Yu Liu, Pao-Hsin Liao, Janet Ing-Yuh Chou, Ming-Yung Chou, Wei-Wen Lin, and Jaw-Ji Yang. ZAK negatively regulates RhoGDIβ-induced Rac1-mediated hypertrophic growth and cell migration. Journal of Biomedical Science 2009 Jun 18;16:56 (First Author)
  • Chih-Yang Huang, Li-Chiu Yang, Kuan-Yu Liu, Pao-Hsin Liao Liao, Janet Ing-Yuh Chou, Ming-Yung Chou, Wei-Wen Lin and Jaw-Ji Yang RhoGDIbeta-induced hypertrophic growth in H9c2 cells is negatively regulated by ZAK. Journal of Biomedical Science 2009 Jan 22;16:11(First Author).
  • Ray-Jade Chen, Wei-Wen Kuo, Mu-Hsin Chang, Chao-Hung Lai, Jin-Ming Hwang, Wu-Hsien Kuo, Fuu-Jen Tsai, Chang-Hai Tsai, Li-Mien Chen*, Chih-Yang Huang*, Chun-Hsien Chu* Leu27IGF2 plays an opposite role to IGF1 to induce H9c2 cardiomyoblast cell apoptosis via Galphaq signaling. J Mol Endocrinol. 2009 43(6):221-30. (Co-correspondence Author)
  • Chen KY, Liao WJ, Kuo SM, Tsai FJ, Chen YS, Chih-Yang Huang *, Yao CH. Asymmetric chitosan membrane containing collagen I nanospheres for skin tissue engineering. Biomacromolecules. 2009 Jun 8;10(6):1642-9. (co-correspondence Author)
  • Chun-Hsien Chu, Bor-Show Tzang, Li-Mien Chen , Chung-Jung Liu, Fuu-Jen Tsai Chang-Hai Tsai, James A. Lin, Da-Tian Bau*, Chun-Hsu Yao*, Chih-Yang Huang*. Specific Activated IGF2R Induces Mitochondria-dependent Apoptosis through Gαq and Downstream Calcineurin Signaling in Myocardial Cells. Endocrinology. 2009 Jun;150(6):2723-31 (Correspondence Author)
  • Chi-Yuan Chen, Shih-Hwa Chiou, Chih-Yang Huang, Chia-Ing Jan, Su-Chun Lin, Ming-Long Tsai, and Jeng-Fan Lo. Distinct population of highly malignant cells in a head and neck squamous cell carcinoma cell line established by xenograft model., J Biomed Sci. 2009 Nov 16;16:100
  • Chung-Jung Liu, Jeng-Fan Lo, Chia-Hua Kuo, Chun-Hsien Chu, Li-Ming Chen, Fuu-Jen Tsai, Chang-Hai Tsai, Bor-Show Tzang*, Wei-Wen Kuo* and Chih-Yang Huang*. Akt Mediates 17β-Estradiol and/or Estrogen Receptor Inhibition of LPS-Induced Tumor Necrosis Factor-αExpression and Myocardial Cell Apoptosis by Suppressing the JNK1/2 and NFkB Pathway. 2009, J. of Cellular and Molecular Medicine, Sep;13(9B):3655-67. (Correspondence Author)
  • Hwei-Chung Wang, Chiu-Shong Liu, Chung-Hsing Wang, Chia-Ling Chang, Chia-Wen Tsai, Rou-Fen Wang, Chao-Hsiang Chang, Yueh-Sheng Chen, Chang-Fang Chiu*, Da-Tian Bau*, and Chih-Yang Huang* Significant Association of XPD Asp312Asn Polymorphism with Breast Cancer in Taiwanese Patients. CJP 2010, Apr 30;53(2):130-5. (Correspondence Author)
  • Chi-Yuan Chen, Shih-Hwa Chiou, Chih-Yang Huang, Chia-Ing Jan, Su-Chun Lin, Wen-Yuan Hu, Shiu-Huey Chou, Chung-Ji Liu, Jeng-Fan Lo. Tid1 Attenuates EGFR/PI3K/AKT Signaling and Reduces Head and Neck Squamous Cell Carcinoma Malignancy, J. of Pathology 2010, Nov;219(3):347-55
  • Eric Y.C. LAI, Yi-jiun WENG, Wei-wen KUO, Li-mien CHEN, Yun-ting CHUNG, Yueh-min LIN, Fuu-jen TSAI, Chun-hsin LEE, Tung-yuan LAI*, Chih-Yang HUANG*, Yu-lan YEH* Taohe ChengQi Tang ameliorated the acute liver injury induced by carbontetrachloride (CCl4) in rats, Journal of Chinese Integrative Medicine (JCIM) 2010, Jan;8(1):49-55. (co-correspondence Author)
  • Chien-Chung Lin, Min-Ting Tsai, Wei-Wen Su, Li-Ming Chen MD, Tung-Yuan Lai, Jin-Ming Hwang, Hsi-Hsien Hsu, Shiow-Kang Yen*, Chih-Yang Huang*, and Jer-Yuh Liu* Protein kinase C alpha location and the expression of phospho-MEK and MDR1 in hepatitis virus-related hepatocellular carcinoma biopsies, CJP 2010, Apr 30;53(2):112-8. (co-correspondence Author)
  • Shiung Cheng, Su-Fen Liao, Kai-Li Liu, Hsin-Yi Liu, Ching-Lin Wu, Chih-Yang Huang, Mallikarjuna K, Richard William Smith, Chia-Hua Ku. Effect of Dietary Glycemic Index on Substrate Transporter Gene Expression in Human Skeletal Muscle Following Exercise, EJCN 2009 Dec;63(12):1404-10
  • Sheen-Yie Fang, Diahn-Warng Perng, J. Yu-Yun Lee, Ding-Yu Lin*, Chih-Yang Huang* A Open-Label, Multicentre Study of Levocetirizine for the Treatment of Allergic Rhinitis and Urticaria in Taiwanese Patients, CJP 2010, Aug 31;53(4):199-207. (Correspondence Author)
  • Tsai-Ching Hsu, Joung-Liang Lan, Shao-Hsuan Kao, Yin-Chang Liu#, Chih-Yang Huang#, Bor-Show Tzang# Identification of an Autoantibody against Proliferating Cell Nuclear Antigen from a Patient with Systemic Lupus Erythematosus, CJP 2010, Feb 28;53(1):11-8. (co-correspondence Author)
  • Wei-Wen Kuo, Tsai-Ching Hsu, Mei-Haung Chain, Chao-Hung Lai, Wen-Hong Wang, Fuu-Jen Tsai, Chang-Hai Tsai, Chieh-His Wu*, Chih-Yang Huang*, Bor-Show Tzang* Attenuated the Cardiac Mitochondrial-dependent Apoptotic effects by Li-Fu Formula in hamsters fed with a hypercholesterol diet, Evid Based Complement Alternat Med 2010, Article ID 530345, 9 pages (co-correspondence Author)
  • Wei-Hung Hsu*, Tsung-Jung Ho*, Chih-Yang Huang*,Hsu-Chueh Ho, Yi-Ling Liu, Hsu-Jan Liu Ning-Sheng Lai, and Jung-Geng. Acupoint herbal patch for allergic rhinitis: a randomised controlled trial, AJCM 2010, 38(4):661-73 (Co-first Author)
  • Wen-Kuei Fang, Yi-Jiun Weng, Mu-Hsin Chang, Li-Mien Chen, Yueh-Sheng Chen, Hsi-Hsien Hsu, Fuu-Jen Tsai, Chang-Hai Tsai, Wu-Hsien Kuo*, Chih-Yang Huang*, Chung Yen Lu* Proliferative effects of chishao on injured peripheral neurons , AJCM 2010, 38(4):735-43. (co-correspondence Author)
  • Hsien-Tung Chen, Bor-Show Tzang, Yueh-Sheng Chen, Kung-Wei Lee, Wei-Kung Chen, Hwai-Lee Wang, Fuu-Jen Tsai, Chang-Hai Tsai, Tung-Yuan Lai, Ying-Lan Tsai, Chih-Yang Huang*, Chung-Yen Lu* Dangshen (Codonopsis Pilosula) activates IGF-I and FGF-2 pathways to induce Proliferation and Migration Effects in RSC96 Schwann Cells, AJCM 2010, 38(2):359-72. (co-correspondence Author)
  • Yung-Ming Chang, Wu-Hsien Kuo, Tung-Yuan Lai, Ying-Ting Shih, Fuu-Jen Tsai, Chang-Hai Tsai, Wen-Tong Shu, Ying-Yu Chen, Yueh-Sheng Chen, Wei-Wen Kuo, Chih-Yang Huang. RSC96 Schwann cell proliferation and survival induced by Dilong through PI3K/Akt signaling mediated by IGF-I, ECAM 2010, 2011:216148 (Correspondence Author)
  • Yung-Ming Chang, Ying-Ting Shih, Yueh-Sheng Chen, Chien-Liang Liu, Wen-Kuei Fang, Chang-Hai Tsai, Fuu-Jen Tsai, Wei-Wen Kuo, Tung-Yuan Lai, Chih-Yang Huang. Schwann cell migration induced by earthworm extract via activation of PAs and MMP2/9 mediated through ERK1/2 and p38, ECAM 2010, 2011:395458 (Correspondence Author)
  • Da-Tian Bau*, Hwei-Chung Wang*, Chiu-Shong Liu*, Chia-Lin Chang, Su-Yin Chiang, Rou-Fen Wang, Chia-Wen Tsai, Yen-Li Lo, Chao A. Hsiung, Cheng-Chieh Lin, Chih-Yang Huang Single Nucleotide Polymorphism of Exo1 Gene: Association with Gastric Cancer Susceptibility and Interaction with Smoking in Taiwan. Chinese Journal of Physiology, 2010, Dec 31;52(6):411-8. (Correspondence Author)
  • Chih-Yang Huang, Yi-Fan Liou, Shu-Ying Chung, Peiying Pai, Chung-Ben Kan, Chia-Hua Kuo, Chang-Hai Tsai, Jing-Ying Lin. Increased expression of glucose transporter 3 in gerbil brains following magnesium sulfate treatment and focal cerebral ischemic injury., Cell Biochem Funct. 2010 Jun;28(4):313-20, (First Author)
  • Chih-Yang Huang, Yi-Fan Liou, Shu-Ying Chung, Peiying Pai, Chung-Ben Kan, Chia-Hua Kuo, Chang-Hai Tsai, Jing-Ying Lin Role of ERK Signaling in the Neuroprotective Efficacy of Magnesium Sulfate Treatment During Focal Cerebral Ischemia in the Gerbil Cortex. CJP 2010, Oct 31;53(5):299-309. (First Author)
  • Wang W, Chih-Yang Huang,, Tsai FJ, Tsai CC, Yao CH, Chen YS. Growth-promoting effects of quercetin on peripheral nerves in rats. Int J Artif Organs. 2011, Nov;34(11):1095-105
  • Bau DT, Chang CH, Tsai RY, Wang HC, Wang RF, Tsai CW, Yao CH, Chen YS, Shyue SK, Chih-Yang Huang, Significant association of caveolin-1 genotypes with bladder cancer susceptibility in Taiwan. Chin J Physiol. 2011, Jun 30;54(3):153-60. (Correspondence Author)
  • Chen JL, Yeh DP, Lee JP, Chen CY, Chih-Yang Huang, Lee SD, Chen CC, Kuo TB, Kao CL, Kuo CH. Parasympathetic nervous activity mirrors recovery status in weightlifting performance after training. J Strength Cond Res. 2011, Jun;25(6):1546-52
  • Jan CI, Yu CC, Hung MC, Harn HJ, Nieh S, Lee HS, Lou MA, Wu YC, Chen CY, Chih-Yang Huang, Chen FN, Lo JF. Tid1, CHIP and ErbB2 interactions and their prognostic implications for breast cancer patients. J Pathol. 2011, Nov;225(3):424-37.
  • Tien YC, Liao JC, Chiu CS, Huang TH, Chih-Yang Huang, Chang WT, Peng WH. Esculetin ameliorates carbon tetrachloride-mediated hepatic apoptosis in rats. Int J Mol Sci. 2011, 12(6):4053-67.
  • Tsai CY, Lai CH, Chang MH, Jong GP, Cheng YC, Tsai FJ, Tsai CH, Kuo WH, Hsieh DJ, Chih-Yang Huang, IGF-II and MMP9 as surgical repair indicators of ventricular septal defects. Clin Chim Acta. 2011, Apr 11;412(9-10):761-5. (Correspondence Author)
  • Huang KS, Lin JG, Lee HC, Tsai FJ, Bau DT, Chih-Yang Huang, Yao CH, Chen YS. Paeoniae alba Radix Promotes Peripheral Nerve Regeneration. Evid Based Complement Alternat Med.2011, 2011:109809.
  • Hseu YC, Wu CR, Chang HW, Kumar KJ, Lin MK, Chen CS, Cho HJ,Chih-Yang Huang, Lee HZ, Hsieh WT, Chung JG, Wang HM, Yang HL. Inhibitory effects of Physalis angulata on tumor metastasis and angiogenesis. J Ethnopharmacol. 2011, Jun 1;135(3):762-71
  • Chih-Yang Huang,Yu HS, Lai TY, Yeh YL, Su CC, Hsu HH, Tsai FJ, Tsai CH, Wu HC, Tang CH. Leptin increases motility and integrin up-regulation in human prostate cancer cells. J Cell Physiol. 2011, May;226(5):1274-82 (First Author)
  • Chiang YF, Shaw HM, Yang MF, Chih-Yang Huang, Hsieh CH, Chao PM. Dietary oxidised frying oil causes oxidative damage of pancreatic islets and impairment of insulin secretion, effects associated with vitamin E deficiency. Br J Nutr. 2011, May;105(9):1311-9.
  • Chen LM, Kuo CH, Lai TY, Lin YM, Su CC, Hsu HH, Tsai FJ, Tsai CH, Chih-Yang Huang, Tang CH. RANKL increases migration of human lung cancer cells through intercellular adhesion molecule-1 up-regulation. J Cell Biochem. 2011, Mar;112(3):933-41. (Correspondence Author)
  • Lo JF, Yu CC, Chiou SH, Chih-Yang Huang, Jan CI, Lin SC, Liu CJ, Hu WY, Yu YH. The epithelial-mesenchymal transition mediator S100A4 maintains cancer-initiating cells in head and neck cancers. Cancer Res 2011, Mar 1;71(5):1912-23.
  • Chiu YW, Lin TH, Huang WS, Teng CY, Liou YS, Kuo WH, Lin WL, Huang HI, Tung JN, Chih-Yang Huang, Liu JY, Wang WH, Hwang JM, Kuo HC. Baicalein inhibits the migration and invasive properties of human hepatoma cells. Toxicol Appl Pharmacol. 2011, Sep 15;255(3):316-26.
  • Lai TY, Su CC, Kuo WW, Yeh YL, Kuo WH, Tsai FJ, Tsai CH, Weng YJ, Chih-Yang Huang, Chen LM. β-catenin plays a key role in metastasis of human hepatocellular carcinoma. Oncol Rep. 2011, Aug;26(2):415-22. (co-correspondence Author)
  • Chen TS, Liou SY, Wu HC, Tsai FJ, Tsai CH, Chih-Yang Huang, Chang YL. Efficacy of Epigallocatechin-3-Gallate and Amla (Emblica officinalis) Extract for the Treatment of Uremic Diabetic Patients. J Med Food 2011, Jul-Aug;14(7-8):718-23. (co-correspondence Author)
  • JUI-LUNG SHEN,TSAI-CHING HSU, YI-CHEN CHEN, JENG-DONG HSU, LIEN-CHUAN YANG, FUU-JEN TSAI, CHENG-CHIEN LI, YA-WEN CHENG, Chih-Yang Huang, BOR-SHOW TZANG. EFFECTS OF DEEP-SEA WATER ON CARDIAC ABNORMALITY IN HIGH-CHOLESTEROL DIETARY MICE. Journal of Food Biochemistry. 2011, DOI: 10.1111/j.1745-4514.2010.00498 (co-correspondence Author)
  • Chu CH, Lo JF, Hu WS, Lu RB, Chang MH, Tsai FJ, Tsai CH, Weng YS, Tzang BS, Chih-Yang Huang, HistoneQ1 Acetylation Is Essential for ANG-II-Induced IGF-IIR Gene Expression in H9c2 Cardiomyoblast Cells and Pathologically Hypertensive Rat Heart. J Cell Physiol. 2011, Jan;227(1):259-68 (Correspondence Author)
  • Hsu HH, Hu WS, Lin YM, Kuo WW, Chen LM, Chen WK, Hwang JM, Tsai FJ, Liu CJ, Chih-Yang Huang, JNK suppression is essential for 17b-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells. J Biomed Sci .2011, Aug 22;18:61. (correspondence Author)
  • Kuo MY, Ou HC, Lee WJ, Kuo WW, Hwang LL, Song TY, Chih-Yang Huang,Chiu TH, Tsai KL, Tsai CS, Sheu WH. Ellagic Acid Inhibits Oxidized Low-Density Lipoprotein (OxLDL)-Induced Metalloproteinase (MMP) Expression by Modulatingthe Protein Kinase C-r/Extracellular Signal-Regulated Kinase/Peroxisome Proliferator-Activated Receptor γ/Nuclear Factor-KB(PKC-r/ERK/PP. 2011, May 11;59(9):5100-8.
  • Dung TD, Chang HC, Chen CY, Peng WH, Tsai CH, Tsai FJ, Kuo WW, Chen LM, Chih-Yang Huang, Zanthoxylum avicennae extracts induce cell apoptosis through protein phosphatase 2A activation in HA22T human hepatocellular carcinoma cells and block tumor growth in xenografted nude mice. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2011, Dec;28(6):927-36 (Correspondence Author)
  • Shen JL, Chen YS, Lin JY, Tien YC, Peng WH, Kuo CH, Tzang BS, Wang HL, Tsai FJ, Chou MC, Chih-Yang Huang, Lin CC. Neuron Regeneration and Proliferation Effects of Danshen and Tanshinone IIA. Evid Based Complement Alternat Med. 2011, 2011:378907 (co-correspondence Author)
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  • Yang CH, Ting WJ, Day CH, Ju DT, Yeh YL, Chung LC, Tsai FJ, Tsai CH, Tsai Y, Chih-Yang Huang.SHSST cyclodextrin complex prevents the fibrosis effect on CCl₄-induced cirrhotic cardiomyopathy in rats through TGF-β pathway inhibition effects. Int J Mol Sci. 2014 May 8;15(5):8037-48. (correspondence Author)
  • Hu WS, Ho TJ, Pai P, Chung LC, Kuo CH, Chang SH, Tsai FJ, Tsai CH, Jie YC, Liou YM, Chih-Yang Huang.Gelsolin (GSN) induces cardiomyocyte hypertrophy and BNP expression via p38 signaling and GATA-4 transcriptional factor activation. MOLECULAR AND CELLULAR BIOCHEMISTRY. 2014 May;390(1-2):263-70. (Correspondence Author)
  • Ming-Jen Fan,Rosa Huang-Liu,Chia-Yao Shen,Da-Tong Ju, Yueh-Min Lin, Peiying Pai, Pi-Yu Huang, Tsung-Jung Ho,Fuu-Jen Tsai,Chang-Hai Tsai, Chih-Yang Huang, Reduction of TLR4 mRNA stability and protein expressions through inhibiting cytoplasmic translocation of HuR transcription factor by E2 and/or ERα in LPS-treated H9c2 cardiomyoblast cells. CHINESE JOURNAL OF PHYSIOLOGY.2014 28:57(1) 8-18(Correspondence Author)
  • Hsu HH, Cheng LH, Ho TJ, Kuo WW, Lin YM, Chen MC, Lee NH, Tsai FJ, Tsai KH, Chih-Yang Huang .Apicidin-resistant HA22T hepatocellular carcinoma cells massively promote pro-survival capability via IGF-IR/PI3K/Akt signaling pathway activation. Tumour Biol. 2014 35(1):303-13. (correspondence Author)
  • Tien-Huang Lin,Wen-Chi Chen,Hsi-Chin Wu,Wen-Shin Chien,Shang-Seu Lec, Fu-Jenn Tsai, Chang-Hai Tsai,Wei-Jen Ting,Sheng-Chu Kuo, Chih-Yang Huang, Induction of Apoptosis in Human DU145 Prostate Cancer Cells by KHC-4 Treatment. CHINESE JOURNAL OF PHYSIOLOGY.2014 30;57(2): (correspondence Author)
  • Wu MH, Chih-Yang Huang, Lin JA, Wang SW, Peng CY, Cheng HC, Tang CH. Endothelin-1 promotes vascular endothelial growth factor-dependent angiogenesis in human chondrosarcoma cells. ONCOGENE 2014 33(13):1725-35
  • Shur-Hueih Cherng, Chih-Yang Huang, Wei-Wen Kuo, Chien-Yu Tseng, Yueh-Min Lin, Fuu-Jen Tsai Hsueh-Fang Wang. GABA Tea Prevents Cardiac Fibrosis by Attenuating TNF-alpha and Fas/FasL-mediated apoptosis in Streptozotocin-Induced Diabetic Rats. FOOD AND CHEMICAL TOXICOLOGY.2014 65:90 -96 (First Author)
  • Lin CC1, Chao PY, Shen CY, Shu JJ, Yen SK, Chih-Yang Huang, Liu JY. Novel target genes responsive to apoptotic activity by Ocimum gratissimum in human osteosarcoma cells. Am J Chin Med. 2014;42(3):743-67. (co-correspondence Author)
  • Ming-Cheng Chen, Nien-Hung Lee, Tsung-Jung Ho, Chia-Hua Kuo, Wei-Wen Kuo, Yueh-Min Lin, Fuu-Jen Tsai,Hsi-Hsien Hsu, Chang-Hai Tsai, Chih-Yang Huang. Resistance to Irinotecan (CPT-11) activates Epidermal Growth Factor Receptor/Nuclear Factor Kappa B and Increases Cellular Metastasis and Autophagy in LoVo Colon Cancer Cells. CANCER LETTERS 2014 349(1):51-60. (Correspondence Author)
  • Lai CH, Ho TJ, Kuo WW, Day CH, Pai PY, Chung LC, Liao PH, Lin FH, Wu ET, Chih-Yang Huang. Exercise training enhanced SIRT1 longevity signaling replaces the IGF1 survival pathway to attenuate aging-induced rat heart apoptosis. Age (Dordr). 2014 Oct;36(5):9706(Correspondence Author)
  • Chih-Yang Huang, Wei-Wen Kuo, Yu-Lan Yeh, Tsung-Jung Ho, Jing-Ying Lin, Ding-Yu Lin, Chun-Hsien Chu, Fu-Jen Tsai, Chang-Hai Tsai , Chih-Yang Huang. ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation. CELL DEATH AND DIFFERENTIATION (IF=8.3).2014 21(8):1262-74. (Correspondence Author)
  • Chou SH, Lin SZ, Kuo WW, Pai P, Lin JY, Lai CH, Kuo CH, Lin KH, Tsai FJ, Chih-Yang Huang. Mesenchymal Stem Cell Insights: Prospects in Cardiovascular Therapy. Cell Transplant. 2014;23(4-5):513-29 (Correspondence Author)
  • Lin E, Chen MC, Huang CY, Hsu SL, Huang WJ, Lin MS, Wu JC, Lin H. All-trans retinoic acid induces DU145 cell cycle arrest through Cdk5 activation. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 2014 ;33(6):1620-30
  • Chih-Yang Huang, Kuo WW, Shibu MA, Hsueh MF, Chen YS, Tsai FJ, Yao CH, Lin CC, Pan LF, Ju DT. Citrus medica var. sarcodactylis (Foshou) activates fibroblast growth factor-2 signaling to induce migration of RSC96 Schwann cells. AMERICAN JOURNAL OF CHINESE MEDICINE 2014;42(2):443-52. (Correspondence Author)
  • Chih-Yang Huang, Cooper EL, Fang-Yeu Poh C, Kuo WW, Chen TS, Sherman R. Special invertebrate models and integrative medical applications: regulations, mechanisms, and therapies. Evid Based Complement Alternat Med. 2014;2014:843961. (First Author)
  • Lin CH, Lin CC, Ting WJ, Pai PY, Kuo CH, Ho TJ, Kuo WW, Chang CH, Chih-Yang Huang, Lin WT. Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts. AGE. 2014 Oct;36(5):9705. (co-correspondence Author)
  • Wu JP, Hsieh CH, Ho TJ, Kuo WW, Yeh YL, Lin CC, Kuo CH, Chih-Yang Huang, Secondhand smoke exposure toxicity accelerates age-related cardiac disease in old hamsters. BMC Cardiovasc Disord. 2014 19;14:195. (Correspondence Author)
  • Hsieh YL, Pai P, Ho TJ, Chung LC, Cheng YC, Wu CH, Fan MJ, Day CH, Shen CY, Chih-Yang Huang, Effects of Garlic Oil on Interleukin-6 Mediated Cardiac Hypertrophy in Hypercholesterol-Fed Hamsters. CHINESE JOURNAL OF PHYSIOLOGY 2014 57(6):320-8
  • Lin CC, Chao PY, Shen CY, Shu JJ, Yen SK, Chih-Yang Huang, Liu JY. Novel Target Genes Responsive to Apoptotic Activity by Ocimum gratissimum Extracts in Human Osteosarcoma cells. AMERICAN JOURNAL OF CHINESE MEDICINE 2014;42(3):743-67. (co-correspondence Author)
  • Chang CW, Chen YS, Chou SH, Han CL, Chen YJ, Yang CC, Chih-Yang Huang, Lo JF. Distinct subpopulations of head and neck cancer cells with different levels of intracellular reactive oxygen species exhibit diverse stemness, proliferation, and chemosensitivity. CANCER RESEARCH 2014 Nov 1;74(21):6291-305. (co-correspondence Author)
  • Ming-Chieh Wu,Ying-Lan Tsai, Chih-Yang Huang , Chung-Lan Kao , Chien-Wen Hou, Chung-Yu Chen , Mallikarjuna Korivi, Wei-Horng Jean, Shin-Da Lee, Chia-Hua Kuo. Hyperinsulinemia and overweight in obese Zucker rats effectively suppressed by exercise training with hypoxia recovery. European Journal of Sport Science 2014 DOI:10.1080/17461391.
  • Hsu HH, Kuo WW, Ju DT, Yeh YL, Tu CC, Tsai YL, Shen CY, Chang SH, Chung LC, Chih-Yang Huang , Estradiol agonists inhibit human LoVo colorectal-cancer cell proliferation and migration through p53. WORLD JOURNAL OF GASTROENTEROLOGY 2014 Nov 28;20(44):16665-73 (Correspondence Author)
  • Deng JS, Lee SD, Kuo WW, Fan MJ, Lin YM, Hu WS, Huang YC, Velmurugan BK, Tsai FJ, Tsai CH, Chih-Yang Huang , Anti-apoptotic and pro-survival effect of protocatechuic acid on hypertensive hearts. CHEMICO-BIOLOGICAL INTERACTIONS 2014 Feb 25;209:77-84. (Correspondence Author)
  • Chang HC, Chiu YW, Lin YM, Chen RJ, Lin JA, Tsai FJ, Tsai CH, Kuo YC, Liu JY, Chih-Yang Huang , Herbal Supplement Attenuation of Cardiac Fibrosis in Rats with CCl4-Induced Liver Cirrhosis CHINESE JOURNAL OF PHYSIOLOGY 2014 Feb 28;57(1):41-7. (correspondence Author)
  • Chih Yang Huang, Catherine Reena Paul, Peiying Pai, Wen-Dee Chiang, Tsung-Jung Ho,Wan-Teng Lin. Potato Protein Hydrolysate- APPH Attenuates High Fat Diet-Induced Cardiac Apoptosis and Enhances Survival Through SIRT1/ PGC-1/Akt Signaling. Journal of Functional Foods.2015 (First Author)
  • Wang ZH, Hsu HW, Chou JC, Yu CH, Bau DT, Wang GJ, Chih Yang Huang, Wang PS, Wang SW. Cytotoxic Effect of S-Petasin and Iso-S-Petasin on the Proliferation of Human Prostate Cancer Cells. ANTICANCER RESEARCH 2015 35(1):191-9.
  • Liao HE, Shibu MA, Kuo WW, Pai PY, Ho TJ, Kuo CH, Lin JY, Pai PY, Viswanadha VP, Chih-Yang Huang, Deep Sea Minerals Prolong Life Span of Streptozotocin-Induced Diabetic Rats by Compensatory Augmentation of the IGF-I-Survival Signaling and Inhibition of Apoptosis. ENVIRONMENTAL TOXICOLOGY 2015 doi: 10.1002(Correspondence Author)
  • Lin KH, Kuo CH, Kuo WW, Ho TJ, Pai P, Chen WK, Pan LF, Wang CC, Padma VV, Chih-Yang Huang, NFIL3 Suppresses Hypoxia-induced Apoptotic Cell Death by Targeting the Insulin-like Growth Factor 2 Receptor. J Cell Biochem. 2015 Jun;116(6):1113-20. (Correspondence Author)
  • Wang HF, Lin PP, Chen CH, Yeh YL, Huang CC, Chih-Yang Huang, Tsai CC. Effects of lactic acid bacteria on cardiac apoptosis are mediated by activation of the phosphatidylinositol-3 kinase/AKT survival-signalling pathway in rats fed a high-fat diet. Int J Mol Med. 2015 Feb;35(2):460-70. (co-correspondence Author)
  • Chao-Hung Lai, Chien-Kuo Han, Marthandam Asokan Shibu, Pei Ying Pai, Tsung- Jung Ho, Cecilia Hsuan Day, Fuu-Jen Tsai, Chang-Hai Tsai, Chun-Hsu Yao, Chih-Yang Huang,Lumbrokinase from earthworm extract ameliorates second-hand smoke induced cardiac fibrosis. Environ Toxicol. 2015 Sep;30(10):1216-25. (correspondence Author)
  • Chung-Ben Kan, Yu-LanYeh,Cecilia-Hsuan Day, Chia-Yao Shen, Li-Chin Chung, Sheng-Huang Chang, Chao-Hung Lai, Jer-Yuh Liu, Chien-Chung Lin, Chih-Yang Huang.Attenuation of Crude Water Extract of the Leaves of Ocimum gratissimum on the Cardiac Mitochondria-Dependent Apoptotic Pathway Effects in Hypercholesterol Fed Hamsters. Adaptive Medicine.2015 (Correspondence Author)
  • Hsu TC, Chiou CC, Lin HL, Kao TW, Chen LJ, Wu LY, Chih-Yang Huang, Tzang BS. Attenuated Effects of Deep-Sea Water on Hepatic Apoptosis in STZ-Induced Diabetic Rats. Chin J Physiol. 2015 Jun 30;58(3):197-205. (co-correspondence Author)
  • CHENG HSUN YANG, WEI-JEN TING, CHIA-YAO SHEN, HIS-HSIEN HSU, YUEH-MIN LIN, SHENG-HUANG CHANG, FUU-JEN TSAI, VISWANADHA VIJAYA PADMA, Chih-Yang Huang SHSST‑cyclodextrin complex inhibits TGF β/Smad3/CTGF to a greater extent than silymarin in a rat model of carbon tetrachloride induced liver injury. Molecular Medicine Reports 2015 Oct;12(4):6053-9. 2015(Correspondence Author)
  • Sheng-Huang C, Chieh-Hsin C, Mu-Chun Y, Wen-Tung H, Chia-Ying H, Ya-Ting H, Wan-Ling SU, Jiuan-Jen S, Chih-Yang Huang, Jer-Yuh. Effects of estrogen on glutathione and catalase levels in human erythrocyte during menstrual cycle. Biomed Rep. 2015 Mar;3(2):266-268.
  • Chen TS, Liou SY, Kuo WW, Wu HC, Jong GP, Wang HF, Shen CY, Padma VV, Chih-Yang Huang, Chang YL. Rapid method for the quantification of hydroquinone concentration: chemiluminescent analysis. Luminescence. 2015 Nov;30(7):947-9. (co-correspondence Author)
  • Chih-Yang Huang, Chen SY, Fu RH, Huang YC, Chen SY, Shyu WC, Lin SZ, Liu SP. Differentiation of Embryonic Stem Cells Into Cardiomyocytes Used to Investigate the Cardioprotective Effect of Salvianolic Acid B Through BNIP3 Involved Pathway. CELL TRANSPLANTATION 2015;24(3):561-71. (First Author)
  • Hsieh DJ, Huang CY, Pai P, Wang SG, Tsai YL, Li CN, Kuo WW Chih-Yang Huang,Prolactin protects cardiomyocytes against intermittent hypoxia-induced cell damage by the modulation of signaling pathways related to cardiac hypertrophy and proliferation. INTERNATIONAL JOURNAL OF CARDIOLOGY 2015 Feb 15;181:255-66. (Correspondence Author)
  • Yue CH, Chih-Yang Huang, Tsai JH, Hsu CW, Hsieh YH, Lin H, Liu JY. MZF-1/Elk-1 complex binds to protein kinase Cα promoter and is involved in hepatocellular carcinoma. PLoS One 2015 26;10(5):e0127420
  • Dennis Jine-Yuan Hsieha, Wei-Wen Kuo Yi-Ping Lai Marthandam Asokan Shibu Chia-Yao Shen Peiying Pai, Yu-LanYeh Jing-Ying Lin, Vijaya PadmaViswanadha, Chih-Yang Huang, 17β-Estradiol and/or Estrogen Receptor β Attenuate the Autophagic and Apoptotic Effects Induced by Prolonged Hypoxia Through HIF-1α-Mediated BNIP3 and IGFBP-3 Signaling Blockage. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 2015;36:274-284 (Correspondence Author)
  • Hu WS, Ting WJ, Chiang WD, Pai P, Yeh YL, Chang CH, Lin WT, Chih-Yang Huang.The Heart Protection Effect of Alcalase Potato Protein Hydrolysate Is through IGF1R-PI3K-Akt Compensatory Reactivation in Aging Rats on High Fat Diets. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2015 May 5;16(5):10158-72 (correspondence Author)
  • Hsieh YL, Tsai YL, Shibu MA, Su CC, Chung LC, Pai P, Kuo CH, Yeh YL, Viswanadha VP, Chih-Yang Huang. ZAK induces cardiomyocyte hypertrophy and brain natriuretic peptide expression via p38/JNK signaling and GATA4/c-Jun transcriptional factor activation. MOLECULAR AND CELLULAR BIOCHEMISTRY 2015 Jul;405(1-2):1-9. (Correspondence Author)
  • Chih-Yang Huang, Hsu TC, Kuo WW, Liou YF, Lee SD, Ju DT, Kuo CH, Tzang BS. The Root Extract of Gentiana macrophylla Pall. Alleviates Cardiac Apoptosis in Lupus Prone Mice. PLoS One 2015 18;10(5):e0127440 (First Author)
  • Da-Tong Ju,Wei-Wen Kuo,Tsung-Jung Ho,Catherine Reena Paul,Chia-Hua Kuo,Fuu-Jen Tsai,Chien-Chung Lin,Yueh-Sheng Chen,Yung-Ming Chang. Chih-Yang Huang, Protocatechuic Acid from Alpinia oxyphylla Induces Schwann Cell Migration via ERK1/2,JNK and p38 Activation. Am J Chin Med. 2015;43(4):653-65 (Correspondence Author)
  • Tsai CY, Wen SY, Shibu MA, Yang YC, Peng H, Wang B, Wei YM, Chang HY, Lee CY, Chih-Yang Huang, Kuo WW. Diallyl trisulfide protects against high glucose–induced cardiac apoptosis by stimulating the production of Cystathionine gamma-lyase-derived hydrogen sulfide. INTERNATIONAL JOURNAL OF CARDIOLOGY 2015 2015 May 20;195:300-310. (co-correspondence Author)
  • Lin KH, Kuo WW, Jiang AZ, Pai P, Lin JY, Chen WK, Day CH, Shen CY, Padma VV, Chih-Yang Huang.Tetramethylpyrazine Ameliorated Hypoxia-induced Myocardial Cell Apoptosis via HIF-1α/JNK/p38 and IGFBP3/BNIP3 Inhibition to upregulate PI3K/Akt. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 2015;36(1):334-44. (Correspondence Author)
  • Chen MC, Lee NH, Hsu HH, Ho TJ, Tu CC, Hsieh DJ, Lin YM, Chen LM, Kuo WW, Chih-Yang Huang. Thymoquinone Induces Caspase-Independent, Autophagic Cell Death in CPT-11-Resistant LoVo Colon Cancer via Mitochondrial Dysfunction and Activation of JNK and p38. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2015 11;63(5):1540-6. (Correspondence Author)
  • Chang WH, Tsai YL, Chih-Yang Huang,, Hsieh CC, Chaunchaiyakul R, Fang Y, Lee SD, Kuo CH. Null effect of ginsenoside Rb1 on improving glycemic status in men during a resistance training recovery. J Int Soc Sports Nutr. 2015 Aug 20;12:34.
  • Liu YS, Tsai YL, Yeh YL, Chung LC, Wen SY, Kuo CH, Lin YM, Padma VV, Chih-Yang Huang, Cell Cycle Regulation in the Estrogen Receptor Beta (ESR2)-Overexpressing Hep3B Hepatocellular Carcinoma Cell Line. CHINESE JOURNAL OF PHYSIOLOGY 2015 Apr 30;58(2):134-40. (Correspondence Author)
  • Liao HE, Lai CH, Ho TJ, Yeh YL, Jong GP, Kuo WH, Chung LC, Pai PY, Wen SY, Chih-Yang Huang, Cardio Protective Effects of Lumbrokinase and Dilong on Second-Hand Smoke-Induced Apoptotic Signaling in the Heart of a Rat Model. CHINESE JOURNAL OF PHYSIOLOGY 2015 Jun 30;58(3). (Correspondence Author)
  • Chih-Yang Huang, Hsu TC, Kuo WW, Liou YF, Lee SD, Ju DT, Kuo CH, Tzang BS. The Root Extract of Gentiana macrophylla Pall. Alleviates Cardiac Apoptosis in Lupus Prone Mice. PLoS One.2015 18;10(5):e0127440. (First Author)
  • Ting WJ, Kuo WW, Kuo CH, Yeh YL, Shen CY, Chen YH, Ho TJ, Viswanadha VP, Chen YH, Chih-Yang Huang. Supplementary heat-killed Lactobacillus reuteri GMNL-263 ameliorates hyperlipidaemic and cardiac apoptosis in high-fat diet-fed hamsters to maintain cardiovascular function. BRITISH JOURNAL OF NUTRITION. 2015 114, 706–712 (Correspondence Author)
  • Wu JP, Tsai CC, Yeh YL, Lin YM, Lin CC, Day CH, Shen CY, Padma VV, Pan LF, Chih-Yang Huang. Silymarin Accelerates Liver Regeneration after Partial Hepatectomy. Evidence-based Complementary and Alternative Medicine. 2015 doi: 10.1155/2015/603529 (Correspondence Author)
  • Lin YM, Kuo WW, Velmurugan BK, Hsien HH, Hsieh YL, Hsu HH, Tu CC, Bau DT, Viswanadha VP, Chih-Yang Huang. Helioxanthin suppresses the cross talk of COX-2/PGE2 and EGFR/ERK pathway to inhibit Arecoline-induced Oral Cancer Cell (T28) proliferation and blocks tumor growth in xenografted nude mice. Environ Toxicol 2015 Oct 14. doi: 10 (Correspondence Author)
  • Wu JP, Hsieh DJ, Kuo WW, Han CK, Pai P, Yeh YL, Lin CC, Padma VV, Day CH, Chih-Yang Huang. Secondhand Smoke Exposure Reduced the Compen satory Effects of IGF-I Growth Signaling in the Aging Rat Hearts. International Journal of Medical Sciences. 2015 12(9): 708-718. (Correspondence Author)
  • Yeh-Peng Chen,Chia-Wen Tsai, Dennis Jine-Yuan Hsieh, Chia-Yao Shen, Tsung- Jung Ho, V. Vijaya Padma, Wei- Wen Kuo, Chih-Yang Huang . Tetramethylpyrazine Ameliorated Hypoxia-induced Myocardial Cell Apoptosis via HIF-1α/JNK/p38 and IGFBP3/BNIP3 Inhibition to upregulate PI3K/Akt. Cell Physiol Biochem. 2015;36(1):334-44 (correspondence Author)
  • Po-Hsiang Liao, Dennis Jine-Yuan Hsieh, Chia-Hua Kuo, Cecilia-Hsuan Day , Chia-Yao Shen, Chao-Hung Lai, Ray-Jade Chen, V. Vijaya Padma, Wei- Wen Kuo, Chih-Yang Huang .Moderate exercise training attenuates aging-induced cardiac inflammation, hypertrophy and fibrosis injuries of rat hearts. Oncotarget 2015 Nov 3;6(34):35383-94 (correspondence Author)
  • Yue CH, Chih-Yang Huang, Tsai JH, Hsu CW, Hsieh YH, Lin H, Liu JY. MZF-1/Elk-1 Complex Binds to Protein Kinase Cα Promoter and Is Involved in Hepatocellular Carcinoma. PLoS One. 2015 Jun 15;10(6):e0131036
  • Yue CH, Chih-Yang Huang, Tsai JH, Hsu CW, Hsieh YH, Lin H, Liu JY. complex binds to protein kinase Cα promoter and is involved in hepatocellular carcinoma. PLoS One 2015 May 26;10(5):e0127420
  • Liu YL, Huang CC, Chang CC, Chou CY, Lin SY, Wang IK, Hsieh DJ, Jong GP, Chih-Yang Huang, Wang CM . Hyperphosphate-Induced Myocardial Hypertrophy through the GATA-4/NFAT-3 Signaling Pathway Is Attenuated by ERK Inhibitor Treatment. CardioRenal Medicine. 2015 Apr;5(2):79-88.
  • Hsu TC, Chiu CC, Lin HL, Kao TW, Chen LJ, Wu LY, Chih-Yang Huang, Tzang BS. Attenuated Effects of Deep-Sea Water on Hepatic Apoptosis in STZ-Induced Diabetic Rats. Chin J Physiol. 2015 Jun 30;58(3):197-205. (co-correspondence Author)
  • Jin G, Lee SW, Zhang X, Cai Z, Gao Y, Chou PC, Rezaeian AH, Han F, Wang CY, Yao JC, Gong Z, Chan CH, Chih-Yang Huang, Tsai FJ, Tsai CH, Tu SH, Wu CH, Sarbassov dos D2, Ho YS8, Lin HK9. Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1. Mol Cell. 2015 Jun 18;58(6):989-1000.
  • Shen CH, Lin TH, Hsieh YL, Shen CY, Kuo SC, Wu HC, Chien WS, Hsieh DJ, Wen SY, Ting WJ, Yao CH, Chih-Yang Huang, Mitotic arrest induced in human DU145 prostate cancer cells in response to KHC-4 treatment. Environ Toxicol. 2015 Aug 25. (Correspondence Author)
  • Palanisamy K, Krishnaswamy R, Paramasivan P, Chih-Yang Huang, Vishwanadha VP. Eicosapentaenoic acid prevents TCDD-induced oxidative stress and inflammatory response by modulating MAP kinases and redox-sensitive transcription factors. Br J Pharmacol. 2015 Oct;172(19):4726-40. (co-correspondence Author)
  • Lai MC, Lin JG, Pai PY, Lai MH, Lin YM, Yeh YL, Cheng SM, Liu YF, Chih-Yang Huang, Lee SD. Effects of rhodiola crenulata on mice hearts under severe sleep apnea. BMC Complement Altern Med. 2015 Jun 25;15:198.
  • Ju DT, Kuo WW, Ho TJ, Paul CR, Kuo CH, Viswanadha VP, Lin CC, Chen YS, Chang YM, Chih-Yang Huang, Protocatechuic Acid from Alpinia oxyphylla Induces Schwann Cell Migration via ERK1/2, JNK and p38 Activation. Am J Chin Med. 2015;43(4):653-65. (Correspondence Author)
  • Chih-Yang Huang, Hsieh YL, Ju DT, Lin CC, Kuo CH, Liou YF, Ho TJ, Tsai CH, Tsai FJ, Lin JY. Attenuation of Magnesium Sulfate on CoCl₂-Induced Cell Death by Activating ERK1/2/MAPK and Inhibiting HIF-1α via Mitochondrial Apoptotic Signaling Suppression in a Neuronal Cell Line. Chin J Physiol. 2015 Aug 31;58(4):244-53. (First Author)
  • Chih-Yang Huang, Tseng KC, Lin MN, Tsai JP, Su CC. Plasma levels of matrix metalloproteinase-2 and -9 in male and female patients with cirrhosis of different. J Clin Pathol. 2015 Nov;68(11):917-22. (First Author)
  • Chang RL, Lin JW, Hsieh DJ, Yeh YL, Shen CY, Day CH, Ho TJ, Viswanadha VP, Kuo WW, Chih-Yang Huang, Long-term hypoxia exposure enhanced IGFBP-3 protein synthesis and secretion resulting in cell apoptosis in H9c2 myocardial cells. Growth Factors. 2015 Aug;33(4):275-81. (Correspondence Author)
  • Chen TS, Liou SY, Kuo WW, Wu HC, Jong GP, Wang HF, Shen CY, Padma VV, Chih-Yang Huang, Chang YL. Rapid method for the quantification of hydroquinone concentration: chemiluminescent analysis. Luminescence. 2015 Nov;30(7):947-9. (co-correspondence Author)
  • Hsun-Nan Kuo, Chih-Yang Huang, Yueh-Min Lin, Li-Chin Chung, Ray-Jade Chen,Adaptation to Oxidative Stress in Uremic Patients with Hemodialysis:Role of Functional Foods. Adaptive Medicine. 2015 7(3): 111-116 (CO-First Author)
  • Yeh-Peng Chen, Chia-Wen Tsai, Dennis Jine-Yuan Hsieh, Chia-Yao Shen, Tsung-Jung Ho, V. Vijaya Padma, Wei- Wen Kuo, Chih-Yang Huang, Tetramethylpyrazine (TMP) switches energy signaling from the PKCζ-GLUT4-glucose pathway back to the SIRT1-CD36-fatty acid pathway similar to resveratrol to ameliorate cardiac myocyte lipotoxicity. Journal of Functional Foods.2015 (correspondence Author)
  • Yueh-Shan Weng,T Hsueh-Fang Wang,Pei-Ying Pai,Gwo-Ping Jong,Chao-Hung Lai,Li-Chin Chung,Dennis Jine-Yuan Hsieh,Cecilia HsuanDay,Wei-Wen Kuo Chih-Yang Huang, Tanshinone IIA Prevents Leu27IGF-II-induced Cardiomyocyte Hypertrophy Mediated by Estrogen Receptor and Subsequent Akt Activation. AMERICAN JOURNAL OF CHINESE MEDICINE. 2015 Vol. 43, No. 8, 1–25 (correspondence Author)
  • Kuan-Ho Lin, Shibu MA, Kuo YH, Chen YC, Hsu HH, Bau DT, Chen MC, Tu CC, Viswanadha VP, Chih-Yang Huang,Taiwanin C Selectively Inhibits Arecoline and 4-NQO-Induced Oral Cancer Cell Proliferation Via ERK1/2 Inactivation. ENVIRONMENTAL TOXICOLOGY 2015 Nov 5. doi: 10.1002 (Correspondence Author)
  • Shu-Nu Chang Lee, Tsung-Jung Ho, Marthandam Asokan Shibu,Cecilia Hsuan Day,Vijaya Padma Viswanadha,Chao-Hung Lai,Yi-Li Chen,Fuu-Jen Tsai,Yueh-Sheng Chen, Chih-Yang Huang, Protective effects of electroacupuncture at LR3 on cardiac hypertrophy and apoptosis in hypertensive rats. Acupuncture in Medicine. 2015;0:1–8. (Correspondence Author)
  • Da-Tong Ju, Hung-En Liao, Marthandam Asokan Shibu, Tsung-Jung Ho,Viswanadha Vijaya Padma, Fuu-Jen Tsai, Li-Chin Chung, Cecilia Hsuan Day,Chien-Chung Lin, Chih-Yang Huang, Nerve Regeneration Potential of Protocatechuic Acid in RSC96 Schwann Cells by Induction of Cellular Proliferation and Migration through IGFR-PI3K-Akt. CHINESE JOURNAL OF PHYSIOLOGY. 2015 58(6) (correspondence Author)
  • Jia-Ping Wu, Tsung-Jung Ho, Chin-Chuan Tsai, Yu-Lan Yeh, Chien-Chung Lin,Kuan-Ho Lin, Dennis Jine-Yuan Hsieh, Li-Mien Chen, Lung-Fa Pan , Chih-Yang Huang,Hepatoprotective Effects of Traditional Chinese Medicine on Liver Fibrosis from Ethanol Administration following Partial Hepatectomy. CHINESE JOURNAL OF PHYSIOLOGY.2015 58(6) (Correspondence Author)
  • Chih-Yang Huang, Hsieh YL,Ju DT,Lin CC,Kuo CH,Liou YF,Ho TJ, Tsai CH,Tsai FJ,Jing-Ying Lin. Attenuation of Magnesium Sulfate on CoCl2-Induced Cell Death by Activating ERK1/2/MAPK and Inhibiting HIF-1α via Mitochondrial Apoptotic Signaling Suppression in a Neuronal Cell Line. CHINESE JOURNAL OF PHYSIOLOGY 2015 31;58(4):244-53 (First Author)
  • Wei-Jen Ting, Kuo WW, Hsieh DJ, Yeh YL, Day CH, Chen YH, Chen RJ, Padma VV, Chen YH, Chih-Yang Huang, Heat Killed Lactobacillus Reuteri GMNL-263 Reduces Fibrosis Effects on the Liver and Heart in High Fat Diet-Hamsters via TGF-β Suppression. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2015 28;16(10):25881-96. (correspondence Author)
  • Po-Hsiang Liao, Wei-Wen Kuo, Chia-Hua Kuo,Yu-LanYeh, Chia-Yao Shen, Ya-Hui Chen, Ray-Jade Chen, V. Vijaya Padma, Yi-Hsing Chen, Chih-Yang Huang,Lactobacillus reuteri GMNL-263 reduces hyperlipidaemia and the heart failure process in high-calorie diet-fed induced heart dysfunction in rats. Journal of Functional Foods. 2016:226-235 (correspondence Author)
  • Chong G, Tsai S, Wang LH, Chih-Yang Huang, Lin C. Cryopreservation of the gorgonian endosymbiont Symbiodinium. Scientific Reports. 2016 :12;6:18816.
  • Peiying Pai, Ching Jung Lai, Ching-Yuang Lin, Yi-Fan Liou, Chih-Yang Huang, Shin-Da Lee. Effect of Superoxide Anion Scavenger on Rat Hearts with Chronic Intermittent Hypoxia. Journal of Applied Physiology Published. 2016 : 14:jap.01109.2014.
  • Yeh YL, Tsai HI, Cheng SM, Pai P, Ho TJ, Chen RJ, Lai CH, Huang PJ, Padma VV, Chih-Yang Huang, Mechanism of Taiwan Mingjian Oolong Tea to Inhibit Isoproterenol-Induced Hypertrophy and Apoptosis in Cardiomyoblasts. The American Journal of Chinese Medicine. 2016:44(1):77-86. (Correspondence Author)
  • Tsai CT, Chang YM, Lin SL, Chen YS, Yeh YL, Padma VV, Tsai CC, Chen RJ, Ho TJ, Chih-Yang Huang. Alpinate Oxyphyllae Fructus Inhibits IGFII-Related Signaling Pathway to Attenuate Ang II-Induced Pathological Hypertrophy in H9c2 Cardiomyoblasts. Journal of Medicinal Food. 2016;19(3):300-9. (Correspondence Author)
  • Chen YF, Velmurugan BK, Wang HL, Tu CC, Che RJ, Chen MC, Jen LB, Vishwanadha VP, Hsu HH, Chih-Yang Huang. Estrogen and ERα enhanced β-catenin degradation and suppressed its downstream target genes to block the metastatic function of HA22T hepatocellular carcinoma cells via modulating GSK-3β and β-TrCP expression. Environ Toxicol. 2016 Mar 18. (Correspondence Author)
  • Chih-Yang Huang, Liou SY, Kuo WW, Wu HC, Chang YL, Chen TS Chemiluminescence analysis of antioxidant capacity for serum albumin isolated from healthy or uremic volunteers. Luminescence. 2016 Apr 7. doi: 10.1002 (First Author)
  • Chang RL, Lin JW, Kuo WW, Hsieh DJ, Yeh YL, Shen CY, Day CH, Ho TJ, Viswanadha VP, Chih-Yang Huang. Angiotensin-(1-7) attenuated long-term hypoxia-stimulated cardiomyocyte apoptosis by inhibiting HIF-1α nuclear translocation via Mas receptor regulation. Growth Factors. 2016 Apr 8:1-8. (Correspondence Author)
  • Chen PY, Hou CW, Shibu MA, Day CH, Pai P, Liu ZR, Lin TY, Viswanadha VP, Kuo CH, Chih-Yang Huang. Protective effect of Co-enzyme Q10 On doxorubicin-induced cardiomyopathy of rat hearts. Environ Toxicol. 2016 Apr 18 (Correspondence Author)
  • Lai CH, Tsai CC, Kuo WW, Ho TJ, Day CH, Pai PY, Chung LC, Huang CC, Wang HF, Liao PH, Chih-Yang Huang. Multi-Strain Probiotics Inhibit Cardiac Myopathies and Autophagy to Prevent Heart Injury in High-Fat Diet-Fed Rats. Int J Med Sci. 2016 Mar 30;13(4):277-85 (Correspondence Author)
  • Chen YF, Shibu MA, Fan MJ, Chen MC, Viswanadha VP, Lin YL, Lai CH, Lin KH, Ho TJ, Kuo WW, Chih-Yang Huang. Purple rice anthocyanin extract protects cardiac function in STZ-induced diabetes rat hearts by inhibiting cardiac hypertrophy and fibrosis. J Nutr Biochem. 2016 Feb 26;31:98-105 (correspondence Author)
  • Chen YP, Tsai CW, Shen CY, Day CH, Yeh YL, Chen RJ, Ho TJ, Padma VV, Kuo WW, Chih-Yang Huang. Palmitic acid interferes with energy metabolism balance by adversely switching the SIRT1-CD36-fatty acid pathway to the PKC-GLUT4-glucose pathway in cardiomyoblasts. J Nutr Biochem. 2016 Mar 3;31:137-149. (correspondence Author)
  • Chen YP, Tsai CW, Shen CY, Day CH, Yeh YL, Chen RJ, Ho TJ, Padma VV, Kuo WW, Chih-Yang Huang Palmitic acid interferes with energy metabolism balance by adversely switching the SIRT1-CD36-fatty acid pathway to the PKC zeta-GLUT4-glucose pathway in cardiomyoblasts. JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 2016 May;31:137-49. (correspondence Author)
  • Chen PY, Hou CW, Shibu MA, Day CH, Pai P, Liu ZR, Lin TY, Viswanadha VP, Kuo CH, Chih-Yang Huang. Protective Effect of Co-Enzyme Q10 On Doxorubicin-Induced Cardiomyopathy of Rat Hearts. ENVIRONMENTAL TOXICOLOGY 2016 Apr 18. doi: 10.1002/tox.22270 (correspondence Author)
  • Chen YF, Shibu MA, Fan MJ, Chen MC, Viswanadha VP, Lin YL, Lai CH, Lin KH, Ho TJ, Kuo WW, Chih-Yang Huang. Purple Rice Anthocyanin extract protects cardiac function in STZ -Induced Diabetes Rat Hearts by inhibiting cardiac hypertrophy and fibrosis. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 2016 May;31:98-105. (correspondence Author)
  • Chang YM, Chang HH, Kuo WW, Lin HJ, Yeh YL, Padma Viswanadha V, Tsai CC, Chen RJ, Chang HN, Chih-Yang Huang. Anti-Apoptotic and Pro-Survival Effect of Alpinate Oxyphyllae Fructus (AOF) in a D-Galactose-Induced Aging Heart. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2016 Mar 29;17(4):466. (correspondence Author)
  • Huang CW, Horng CT, Chih-Yang Huang, Cho TH, Tsai YC, Chen LJ, Hsu TC, Tzang BS. Secondhand smoke induces hepatic apoptosis and fibrosis in hamster fetus. HUMAN & EXPERIMENTAL TOXICOLOGY 2016 Sep;35(9):1005-15.
  • Chih-Yang Huang, Tseng KC, Lin MN, Tsai JP, Su CC . Plasma levels of matrix metalloproteinase-2 and -9 in male and female patients with cirrhosis of different aetiologies. JOURNAL OF CLINICAL PATHOLOGY 2016 68(11):917-22. (First Author)
  • Chen TS, Liou SY, Kuo WW, Wu HC, Jong GP, Wang HF, Shen CY, Padma VV, Chih-Yang Huang, Chang YL Rapid method for the quantification of hydroquinone concentration: chemiluminescent analysis. LUMINESCENCE. 2016 ;30(7):947-9. (co-correspondence Author)
  • Chen WK, Kuo WW, Hsieh DJ, Chang HN, Pai PY, Lin KH, Pan LF, Ho TJ, Viswanadha VP, Chih-Yang Huang, CREB Negatively Regulates IGF2R Gene Expression and Downstream Pathways to Inhibit Hypoxia-Induced H9c2 Cardiomyoblast Cell Death. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2016 24;16(11):27921-30. (correspondence Author)
  • Chih-Yang Huang ,Ting WJ, Huang CY, Yang JY, Lin WT. Resveratrol attenuated hydrogen peroxide-induced myocardial apoptosis by autophagic flux. Food & Nutrition Research. 2016 May 20;60:30511 (First Author)
  • Chen MC, Lee NH, Hsu HH, Ho TJ, Tu CC, Chen RJ, Lin YM, Viswanadha VP, Kuo WW, Chih-Yang Huang, Inhibition of NF-jB and Metastasis in Irinotecan (CPT-11)-Resistant LoVo Colon Cancer Cells by Thymoquinone via JNK and p38. ENVIRONMENTAL TOXICOLOGY 2016 Apr 5. doi: 10. (correspondence Author)
  • Chang RL, Lin JW, Kuo WW, Hsieh DJ, Yeh YL, Shen CY, Day CH, Ho TJ, Viswanadha VP, Chih-Yang Huang, Angiotensin-(1-7) attenuated long-term hypoxia-stimulated cardiomyocyte apoptosis by inhibiting HIF-1α nuclear translocation via Mas receptor regulation. GROWTH FACTORS. 2016 Feb;34(1-2):11-8. (correspondence Author)
  • Yeh YL, Ting WJ, Kuo WW, Hsu HH, Lin YM, Shen CY, Chang CH, Padma VV, Tsai Y, Chih-Yang Huang, San Huang Shel Shin Tang beta-cyclodextrin complex augmented the hepatoprotective effects against carbon tetrachloride-induced acute hepatotoxicity in rats. BMC Complement Altern Med. 2016 May 27;16:150 (correspondence Author)
  • Lee CJ, Hsu LS, Yue CH, Lin H, Chiu YW, Lin YY, Chih-Yang Huang,, Hung MC, Liu JY. MZF-1/Elk-1 interaction domain as therapeutic target for protein kinase Cα-based triple-negative breast cancer cells. Oncotarget. 2016 Aug 17 (correspondence Author)
  • Baskaran R, Poornima P, Priya LB, Chih-Yang Huang, Padma VV. Neferine prevents autophagy induced by hypoxia through activation of Akt/mTOR pathway and Nrf2 in muscle cells. BIOMEDICINE & PHARMACOTHERAPY 2016 Aug 29;83:1407-1413.
  • Liao PH, Kuo WW, Hsieh DJ, Yeh YL, Day CH, Chen YH, Chang SH, Padma VV, Chen YH, Chih-Yang Huang, Heat-killed Lactobacillus Reuteri GMNL-263 Prevents Epididymal Fat Accumulation and Cardiac Injury in High-Calorie Diet-Fed Rats. International Journal of Medical Sciences. 2016 Jul 5;13(8):569-77 (correspondence Author)
  • Ting WJ, Yang JJ, Kuo CH, Xiao ZJ, Lu XZ, Yeh YL, Day CH, Wen SY, Viswanadha VP, Jiang CH, Kuo WW, Chih-Yang Huang, Environmental tobacco smoke increases autophagic effects but decreases longevity associated with Sirt-1 protein expression in young C57BL mice hearts. Oncotarget. 2016 May 4 (correspondence Author)
  • You-LiangHsieh, MarthandamAsokanShibu , Chong-KueiLii, VijayaPadmaViswanadha , Yi-LinLin, Chao-HungLai, Yu-FengChen, Kuan-HoLin, Wei-Wen Kuo, Chih-Yang Huang, Andrographispaniculata extractattenuatespathologicalcardiac hypertrophyandapoptosisinhigh-fatdietfedmice. Journal of Ethnopharmacology. 192(2016)170–177 (correspondence Author)
  • Chiang WD, Chih-Yang Huang,, Paul CR, Lee ZY, Lin WT. Lipolysis stimulating peptides of potato protein hydrolysate effectively suppresses high-fat-diet-induced hepatocyte apoptosis and fibrosis in aging rats. Food & Nutrition Research. 2016 Jul 12;60:31417 (First Author)
  • Feng CC, Lin CC, Lai YP, Chen TS, Marthandam Asokan S, Lin JY, Lin KH, Viswanadha VP, Kuo WW, Chih-Yang Huang. Hypoxia suppresses myocardial survival pathway through HIF-1α-IGFBP-3-dependent signaling and enhances cardiomyocyte autophagic and apoptotic. GROWTH FACTORS. 2016 Aug;34(3-4):73-86. (correspondence Author)
  • Chao PY, Lin JA, Ting WJ, Lee HH, Hsieh K, Chiu YW, Lai TJ, Hwang JM, Liu JR, Chih-Yang Huang. Ocimum gratissmum aqueous extract reduces plasma lipid in hypercholesterol-fed hamsters. International Journal of Medical Sciences. 2016 Oct 18;13(11):819-824. (correspondence Author)
  • Tsai CY, Wen SY, Cheng SY, Wang CH, Yang YC, Chih-Yang Huang, Kuo WW. Nrf2 Activation as a Protective Feedback to Limit Cell Death in High Glucose-Exposed Cardiomyocytes. J Cell Biochem. 2016 Nov 9. (co-correspondence Author)
  • Fu CY, Kuo WW, Ho TJ, Wen SY, Lin LC, Tseng YS, Hung HC, Viswanadha VP, Yang JJ,Chih-Yang Huang, ZAKβ antagonizes and ameliorates the cardiac hypertrophic and apoptotic effects induced by ZAKα. Cell Biochem Funct. 2016 Nov 16. (correspondence Author)
  • Zhang X, Li CF, Zhang L, Wu CY, Han L, Jin G, Rezaeian AH, Han F, Liu C, Xu C, Xu X, Chih-Yang Huang, Tsai FJ, Tsai CH, Watabe K11, Lin HK, TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression. Mol Cell. 2016 Nov 17;64(4):803-814
  • Hu WS, Lin YM, Kuo WW, Pan LF, Yeh YL, Li YH, Kuo CH, Chen RJ, Padma VV, Chen TS , Chih-Yang Huang. Suppression of isoproterenol-induced apoptosis in H9c2 cardiomyoblast cells by daidzein through activation of Akt. CHINESE JOURNAL OF PHYSIOLOGY. 2016 Dec 31;59(6).
  • Hsu HH, Kuo WW, Day CH, Shibu MA, Li SY, Chang SH, Shih HN, Chen RJ, Viswanadha VP, Kuo YH, Chih-Yang Huang. Taiwanin E inhibits cell migration in human LoVo colon cancer cells by suppressing MMP-2/9 expression via p38 MAPK pathway. Environ Toxicol. 2016 Nov 3. (correspondence Author)
  • Cheng LH, Hung KF, Huang TF, Hsieh HP, Wang SY, Chih-Yang Huang, Lo JF. Attenuation of cancer-initiating cells stemness properties by abrogating S100A4 calcium binding ability in head and neck cancers. Oncotarget. 2016 Oct 26. (co-correspondence Author)
  • Chih-Yang Huang, Chen TS, Lin CL, Hu WS . Does early onset cataract increase the risk of ischemic stroke? A nationwide retrospective cohort study. Internal and Emergency Medicine ,2016 Dec 22. (First Author)
  • Chih-Yang Huang, Chen TS, Lin CL, Hu WS . Does early onset cataract increase the risk of ischemic stroke? A nationwide retrospective cohort study. Internal and Emergency Medicine ,2016 Dec 22. (First Author)
  • Tsai CY, Wen SY, Cheng SY, Wang CH, Yang YC, Chih-Yang Huang, Kuo WW. Nrf2 Activation as a Protective Feedback to Limit Cell Death in High Glucose-Exposed Cardiomyocytes. JOURNAL OF CELLULAR BIOCHEMISTRY. 2016 Nov 9 (co-correspondence Author)
  • Cheng SY, Yang YC, Ting KL, Wen SY, Viswanadha VP, Chih-Yang Huang, Kuo WW. Lactate Dehydrogenase Downregulation Mediates the Inhibitory Effect of Diallyl Trisulfide on Proliferation, Metastasis, and Invasion in Triple-Negative Breast Cancer. ENVIRONMENTAL TOXICOLOGY 2016 Aug 27 (co-correspondence Author)
  • Chih-Yang Huang,Wei-Wen Kuo, Jeng-Fan Lo,Tsung-Jung Ho, Pei-ying Pai, Shu-Fen Chiang, Pei-Yu Chen, Fu-Jen Tsai, Chang-Hai Tsai,Chih-Yang Huang. Doxorubicin attenuates CHIP-guarded HSF1 nuclear translocation and protein stability to trigger IGF-IIR-dependent cardiomyocyte death. Cell Death & Disease. 2016 3;7(11):e2455. (correspondence Author)
  • Po-Hsiang Liao, Hsi-Hsien Hsu, Tung-Sheng Chen, Ming-Cheng Chen, Cecilia-Hsuan Day, Chuan-Chou Tu, Yueh-Min Lin, Fuu-Jen Tsai, Wei- Wen Kuo, Chih-Yang Huang. Phosphorylation of cofilin-1 by ERK confers HDAC inhibitor resistance in hepatocellular carcinoma cells via decreased ROS-mediated mitochondria injury. ONCOGENE. 2016 Oct 17. doi: 10.1038 (correspondence Author)
  • Tsai CY, Wen SY, Cheng SY, Wang CH, Yang YC, Chih-Yang Huang, Kuo WW. Nrf2 Activation as a Protective Feedback to Limit Cell Death in High Glucose-Exposed Cardiomyocytes. JOURNAL OF CELLULAR BIOCHEMISTRY. 2017 Jul;118(7):1659-1669. (co-correspondence Author)
  • Dhivya V, Priya LB, Chirayil HT, Sathiskumar S, Chih-Yang Huang, Padma VV. Piperine modulates isoproterenol induced myocardial ischemia through antioxidant and anti-dyslipidemic effect in male Wistar rats. Biomedicine & Pharmacotherapy. 2017 Jan 12;87:705-713.
  • Priya LB, Baskaran R, Elangovan P, Dhivya V, Chih-Yang Huang Padma VV. Tinospora cordifolia extract attenuates cadmium-induced biochemical and histological alterations in the heart of male Wistar rats. Biomed Pharmacother. 2017 Jan 4;87:280-287.
  • Chen MC, Lee NH, Hsu HH, Ho TJ, Tu CC, Chen RJ, Lin YM, Padma VV, Kuo WW, Chih-Yang Huang ,Inhibition of NF-κB and metastasis in irinotecan (CPT-11)-resistant LoVo colon cancer cells by thymoquinone via JNK and p38. Environ Toxicol. 2017 Feb;32(2):669-678. (correspondence Author)
  • Hsu HH, Chen MC, Day CH, Lin YM, Li SY, Tu CC, Padma VV, Shih HN, Kuo WW, Chih-Yang Huang. Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation. WORLD JOURNAL OF GASTROENTEROLOGY. 2017 Feb;1(1):1-9. (correspondence Author)
  • Ting WJ, Chih-Yang Huang, Jiang CH, Lin YM, Chung LC, Shen CY Pai PY, Lin KH, Padma VV, Liao SC. Treatment with 17 -Estradiol Reduced Body Weight and the Risk of Cardiovascular Disease in a High-Fat Diet-Induced Animal Model of Obesity. INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES. 2017 Mar; 18(3) : E629.
  • Chin WH, Lay IS, Shibu MA, Ho TJ, Cheng SM, Lin CH, Dung TD, Jeng LB, Padma VV, Chih-Yang Huang. Zanthoxylum avicennae extract enhances GSK-3b to attenuate b-catenin via phosphatase 2A to block metastatic effects of HA22T cells and hepatocellular carcinoma xenografted nude mice. ENVIRONMENTAL TOXICOLOGY. 2017 Apr; DOI: 10.1002/tox.22426. (correspondence Author)
  • Hsieh CH, Pai PY, Wu JP, Ho TJ, Wu CH Shibu MA, Day CH, Padma VV, Chuang HL Chih-Yang Huang. Activation of IGF-I Survival Signaling and Its Compensative Inhibition of the Cardiac Apoptosis on Carotid Arteries Balloon-Injured Rat Hearts. CHINESE JOURNAL OF PHYSIOLOGY. 2017;60(3). (correspondence Author)
  • Chao PY, Lin JA, Hwang JM, Ting WJ, Chih-Yang Huang, Liu JY. Attenuation of Oxidative Stress-Induced Cell Apoptosis in Schwann RSC96 Cells by Ocimum Gratissimum Aqueous Extract. International Journal of Medical Sciences. 2017 Jul; 14(8) : 764-771. (correspondence Author)
  • Wen SY, Tamilselvi S, Shen CY, Day CH, Chun LC Cheng LY, Ou HC, Chen RJ, Padma VV, Kuo WW, Chih-Yang Huang. Protective effect of HDL on NADPH oxidasederived super oxide anion mediates hypoxiainducedcardiomyocyte apoptosis. PLoS One. 2017 Jun;12(6). (correspondence Author)
  • Pai PY, Velmurugan BK, Kuo CH, Yen CY, Ho TJ, Lin YM, Chen YF, Lai CH, Day CH, Chih-Yang Huang. 17β-Estradiol and/or estrogen receptor alpha blocks isoproterenol-induced calcium accumulation and hypertrophy via GSK3b/PP2A/NFAT3/ANP pathway. 2017 Jun; DOI:10.1007/s11010-017-3048-3. (correspondence Author)
  • Chen TS, Liou SY, Kuo CH, Pan LF, Yeh YL, Liou J, Padma VV , Yao CH, Kuo WW, Chih-Yang Huang. Green tea EGCG enhances cardiac function restoration through survival signaling expression in DM rats with autologous adipose tissue-derived stem cells. JOURNAL OF APPLIED PHYSIOLOGY. 2017 May; DOI: 10.1152/japplphysiol.00471.2016. (correspondence Author)
  • Lin YC, Lin CH, Yao HT, Kuo WW, Shen CY, Yeh YL, Ho TJ, Padma VV, Lin YC, Huang CY, Chih-Yang Huang. Platycodon grandiflorum (PG) reverses angiotensin II-induced apoptosis by repressing IGF-IIR expression. JOURNAL OF ETHNOPHARMACOLOGY. 2017 Jun; 205: 41-50.
  • Hsu HH, Lin YM, Shen CY, Shibu MA, Li SY, Chang SH, Lin CC, Chen RJ, Padma, Shih HN, Chih-Yang Huang. Prostaglandin E2-Induced COX-2 Expressions via EP2 and EP4 Signaling Pathways in Human LoVo Colon Cancer Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2017 May;18(6):1132. (correspondence Author)
  • Hsu TC, Chih-Yang Huang, Liu CH, Hsu KC, Chen YH, Tzang BS. Lactobacillus paracasei GMNL-32, Lactobacillus reuteri GMNL-89 and L. reuteri GMNL-263 ameliorate hepatic injuries in lupus-prone mice. BRITISH JOURNAL OF NUTRITION. 2017 Apr; 117(8) : 1066-1074.
  • Lin KH, Kuo WW, Shibu MA, Day CH, Hsieh YL, Chung LC, Chen RJ, Wen SY, Padma VV, Chih-Yang Huang. E2/ER β enhances calcineurin protein degradation and PI3K/Akt/MDM2 signal transduction to inhibit ISO-induced myocardial cell apoptosis. 2017 Apr; 18(892). (correspondence Author)
  • Lin YC, Lin YC, Kuo WW, Shen CY, Chen YF, Lin YM, Ho TJ, Padma VV, Huang CY, Chih-Yang Huang. Platycodin D (PD) attenuates myocardial apoptosis mediated by JNK-SIRT1-HSF1-IGF-IIR-Caspase-3 signaling in hypertensive conditions. Journal of Functional Foods. 2017 Apr; 34: 59-67. (correspondence Author)
  • Chang YM, Chang HH, Lin HJ, Tsai CC, Tsai CT, Chang HN, Lin SL, Padma VV, Chen RJ, Chih-Yang Huang. Inhibition of Cardiac Hypertrophy Effects in D-Galactose-Induced Senescent Hearts by Alpinate Oxyphyllae Fructus Treatment. Evidence-based Complementary and Alternative Medicine. 2017 Apr; DOI:10.1155/2017/2624384. (correspondence Author)
  • Chen YP, Hsu HH, Baskaran R, Wen SY, Shen CY, Day CH, Ho TJ, Padma VV, Kuo WW, Chih-Yang Huang. Short-term hypoxia reverses Ox-LDL-induced CD36 and GLUT4 switching metabolic pathways in H9c2 cardiomyoblast cells. JOURNAL OF CELLULAR BIOCHEMISTRY. 2017 Apr; 1(1) : 1-11. (correspondence Author)
  • Huang CY, Lee FL, Peng SF, Lin KH, Chen RJ, Ho TJ, Tsai FJ, Padma VV, Kuo WW, Chih-Yang Huang. HSF1 phosphorylation by ERK/GSK3 suppresses RNF126 to sustain IGF-IIR expression for hypertension-induced cardiomyocyte hypertrophy. 2017 Apr; DOI:10.1002/jcp.25945. (correspondence Author)
  • Lin YY, Hsieh PS, Cheng YJ, Cheng SM, Chen CN, Chih-Yang Huang, Kuo CH, Kao CL, Shyu WC, Lee SD. Anti-apoptotic and Pro-survival Effects of Food Restriction on High-Fat Diet-Induced Obese Hearts. Cardiovascular Toxicology. 2017 Apr; 17(2) : 163-174.
  • Chang YM, Chang HH, Tsai CC, Lin HJ, Ho TJ, Ye CX, Chiu PL, Chen YS, Chen RJ, Chih-Yang Huang, Lin CC. Alpinia oxyphylla Miq. fruit extract activates IGFR-PI3K/Akt signaling to induce Schwann cell proliferation and sciatic nerve regeneration. BMC Complementary and Alternative Medicine. 2017 Mar; 17(1)184. (correspondence Author)
  • Chih-Yang Huang, Chen TS, Lin Cl, Hu WS. Does early onset cataract increase the risk of ischemic stroke? A nationwide retrospective cohort study. Internal and Emergency Medicine. 2017 June; 12(4);461-465. (First Author)
  • Huang CY, Chen JY, Kuo CH, Pai PY, Ho TJ, Chen TS, Tsai FJ, Padma VV, Kuo WW, Chih-Yang Huang. Mitochondrial ROS-induced ERK1/2 activation and HSF2-mediated AT1R upregulation are required for doxorubicin-induced cardiotoxicity. JOURNAL OF CELLULAR PHYSIOLOGY. 2017Mar; DOI: 10.1002/jcp.25905. (correspondence Author)
  • Zhang X, Li B, Rezaeian AH, Xu X, Chou PC, Jin G, Han F, Pan BS, Wang CY, Long J, Zhang A, Chih-Yang Huang, Tsai FJ, Tsai CH, Logothetis C, Lin HK. H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis. Nat Commun. Nat Commun. 2017 Mar 16;8:14799. doi: 10.1038/ncomms14799.
  • Ting WJ, Chih-Yang Huang, Jiang CH, Lin YM, Chung LC, Shen CY, Pai P, Lin KH, Viswanadha VP, Liao SC. Treatment with 17β-Estradiol Reduced Body Weight and the Risk of Cardiovascular Disease in a High-Fat Diet-Induced Animal Model of Obesity. Int J Mol Sci. 2017 Mar 14;18(3).
  • Chang YM, Chang HH, Tsai CC, Lin HJ, Ho TJ, Ye CX, Chiu PL, Chen YS, Chen RJ, Chih-Yang Huang, Lin CC. Alpinia oxyphylla Miq. fruit extract activates IGFR-PI3K/Akt signaling to induce Schwann cell proliferation and sciatic nerve regeneration. BMC Complement Altern Med. 2017 Mar 31;17(1):184. doi: 10.1186/s12906-017-1695-2.
  • Chen YP, Hsu HH, Baskaran R, Wen SY, Shen CY, Day CH, Ho TJ, Vijaya Padma V, Kuo WW, Chih-Yang Huang. Short-Term Hypoxia Reverses Ox-LDL-Induced CD36 and GLUT4 Switching Metabolic Pathways in H9c2 Cardiomyoblast Cells. J Cell Biochem. 2017 Nov;118(11):3785-3795. (correspondence Author)
  • Chih-Yang Huang, Lee FL, Peng SF, Lin KH, Chen RJ, Ho TJ, Tsai FJ, Padma VV, Kuo WW, Huang CY. HSF1 phosphorylation by ERK/GSK3 suppresses RNF126 to sustain IGF-IIR expression for hypertension-induced cardiomyocyte hypertrophy. J Cell Physiol. 2017 Apr 6. doi: 10.1002/jcp.25945. (First Author)
  • Lin KH, Kuo WW, Shibu MA, Day CH, Hsieh YL, Chung LC, Chen RJ, Wen SY, Viswanadha VP, Chih-Yang Huang. E2/ER β Enhances Calcineurin Protein Degradation and PI3K/Akt/MDM2 Signal Transduction to Inhibit ISO-Induced Myocardial Cell Apoptosis. Int J Mol Sci. 2017 Apr 24;18(4). pii: E892. doi: 10.3390/ijms18040892. (correspondence Author)
  • Lin YC, Lin CH, Yao HT, Kuo WW, Shen CY, Yeh YL, Ho TJ, Padma VV, Lin YC, Chih-Yang Huang, Huang CY. Platycodon grandiflorum (PG) reverses angiotensin II-induced apoptosis by repressing IGF-IIR expression. J Ethnopharmacol. 2017 Jun 9;205:41-50. doi: 10.1016/j.jep.2017.04.028.
  • Chang YM, Chang HH, Lin HJ, Tsai CC, Tsai CT, Chang HN, Lin SL, PadmaViswanadha V, Chen RJ, Chih-Yang Huang. Inhibition of Cardiac Hypertrophy Effects in D-Galactose-Induced Senescent Hearts by Alpinate Oxyphyllae Fructus Treatment. Evid Based Complement Alternat Med. 2017;2017:2624384. doi: 10.1155/2017/2624384. (correspondence Author)
  • Wen SY, Velmurugan BK, Day CH, Shen CY, Chun LC, Tsai YC, Lin YM, Chen RJ, Kuo CH, Chih-Yang Huang. High density lipoprotein (HDL) reverses palmitic acid induced energy metabolism imbalance by switching CD36 and GLUT4 signaling pathways in cardiomyocyte. J Cell Physiol. 2017 Nov;232(11):3020-3029. doi: 10.1002/jcp.26007. (correspondence Author)
  • Hsu TC, Chih-Yang Huang, Liu CH, Hsu KC, Chen YH, Tzang BS. Lactobacillus paracasei GMNL-32, Lactobacillus reuteri GMNL-89 and L. reuteri GMNL-263 ameliorate hepatic injuries in lupus-prone mice. Br J Nutr. 2017 Apr;117(8):1066-1074. doi: 10.1017/S0007114517001039.
  • Hsu MF, Yu SH, Korivi M, Jean WH, Lee SD, Chih-Yang Huang, Liao YH, Lu J, Kuo CH. Hormetic Property of Ginseng Steroids on Anti-Oxidant Status against Exercise Challenge in Rat Skeletal Muscle. Antioxidants (Basel). 2017 May 19;6(2). pii: E36. doi: 10.3390/antiox6020036.
  • Chen TS, Liou SY, Kuo CH, Pan LF, Yeh YL, Liou J, Padma VV, Yao CH, Kuo WW, Chih-Yang Huang. Green tea EGCG enhances cardiac function restoration through expression of survival signaling in DM rats with autologous adipose tissue-derived stem cell. J Appl Physiol (1985). 2017 May 25:jap.00471.2016. doi: 10.1152/japplphysiol. (correspondence Author)
  • Wu HC, Lay IS, Shibu MA, Ho TJ, Cheng SM, Lin CH, Dung TD, Jeng LB, Viswanadha VP, Chih-Yang Huang. Zanthoxylum avicennae extract enhances GSK-3β to attenuate β-catenin via phosphatase 2A to block metastatic effects of HA22T cells and hepatocellular carcinoma xenografted nude mice. Environ Toxicol. 2017 Sep;32(9):2133-2143. doi: 10.1002/tox.22426. (correspondence Author)
  • Pai P, Velmurugan BK, Kuo CH, Yen CY, Ho TJ, Lin YM, Chen YF, Lai CH, Day CH, Chih-Yang Huang. 17β-Estradiol and/or estrogen receptor alpha blocks isoproterenol-induced calcium accumulation and hypertrophy via GSK3β/PP2A/NFAT3/ANP pathway. Mol Cell Biochem. 2017 Jun 2. doi: 10.1007/s11010-017-3048-3. (correspondence Author)
  • Chang Y, Lu X, Shibu MA, Dai YB, Luo J, Zhang Y, Li Y, Zhao P, Zhang Z, Xu Y, Tu ZC, Zhang QW, Yun CH, Chih-Yang Huang, Ding K. Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors. J Med Chem. 2017 Jul 13;60(13):5927-5932. doi: 10.1021/acs.jmedchem.7b00572.
  • Hsu HH, Lin YM, Shen CY, Shibu MA, Li SY, Chang SH, Lin CC, Chen RJ, Viswanadha VP, Shih HN, Chih-Yang Huang. Prostaglandin E2-Induced COX-2 Expressions via EP2 and EP4 Signaling Pathways in Human LoVo Colon Cancer Cells. Int J Mol Sci. 2017 May 25;18(6). pii: E1132. doi: 10.3390/ijms18061132. (correspondence Author)
  • Chang CC, Chen CY, Chih-Yang Huang, Wu CL, Wu HM, Chiu PF, Kor CT, Chen TH, Chang GD, Kuo CC, Wen HC, Huang CY, Chang CH. Urinary glycated uromodulin in diabetic kidney disease. Clin Sci (Lond). 2017 Jul 5;131(15):1815-1829. doi: 10.1042/CS20160978.
  • Asokan Shibu M, Kuo WW, Kuo CH, Day CH, Shen CY, Chung LC, Lai CH, Pan LF, Vijaya Padma V, Chih-Yang Huang. Potential phytoestrogen alternatives exert cardio-protective mechanisms via estrogen receptors. Biomedicine (Taipei). 2017 Jun;7(2):11. doi: 10.1051/bmdcn/2017070204. (correspondence Author)
  • Wen SY, Tamilselvi S, Shen CY, Day CH, Chun LC, Cheng LY, Ou HC, Chen RJ, Viswanadha VP, Kuo WW, Chih-Yang Huang. Protective effect of HDL on NADPH oxidase-derived super oxide anion mediates hypoxia-induced cardiomyocyte apoptosis. PLoS One. 2017 Jun 15;12(6):e0179492. (correspondence Author)
  • Hsieh CH, Pai P, Wu JP, Ho TJ, Wu CH, Shibu MA, Day CH, Viswanadha VP, Chuang HL, Chih-Yang Huang. Activation of IGF-I Survival Signaling and Its Compensative Inhibition of the Cardiac Apoptosis on Carotid Arteries Balloon-Injured Rat Hearts. Chin J Physiol. 2017 Jun 30;60(3):166-173. (correspondence Author)
  • Baskaran R, Priya LB, Kalaiselvi P, Poornima P, Chih-Yang Huang, Padma VV. Neferine from Nelumbo nucifera modulates oxidative stress and cytokines production during hypoxia in human peripheral blood mononuclear cells. Biomed Pharmacother. 2017 Sep;93:730-736.
  • Bharathi Priya L, Baskaran R, Chih-Yang Huang, Vijaya Padma V. Neferine modulates IGF-1R/Nrf2 signaling in doxorubicin treated H9c2 cardiomyoblasts. J Cell Biochem. 2017 Jul 21. doi: 10.1002/jcb.26305.
  • Chih-Yang Huang, Pai PY, Kuo CH, Ho TJ, Lin JY, Lin DY, Tsai FJ, Padma VV, Kuo WW, Huang CY. p53-mediated miR-18 repression activates HSF2 for IGF-IIR-dependent myocyte hypertrophy in hypertension-induced heart failure. Cell Death Dis. 2017 Aug 10;8(8):e2990. (First Author)
  • Lee CY, Kuo WW, Baskaran R, Day CH, Pai PY, Lai CH, Chen YF, Chen RJ, Padma VV, Chih-Yang Huang. Increased β-catenin accumulation and nuclear translocation are associated with concentric hypertrophy in cardiomyocytes. Cardiovasc Pathol. 2017 Jul 12;31:9-16. (correspondence Author)
  • Chen YF, Lee NH, Pai PY, Chung LC, Shen CY, Rajendran P, Chen YF, Chen RJ, Padma Viswanadha V, Kuo WW, Chih-Yang Huang. Tanshinone-induced ERs suppresses IGFII activation to alleviate Ang II-mediated cardiac hypertrophy. J Recept Signal Transduct Res. 2017 Oct;37(5):493-499. (correspondence Author)
  • Chao PY, Lin JA, Ye JC, Hwang JM, Ting WJ, Chih-Yang Huang, Liu JY. Attenuation of Oxidative Stress-Induced Cell Apoptosis in Schwann RSC96 Cells by Ocimum Gratissimum Aqueous Extract. Int J Med Sci. 2017 Jul 18;14(8):764-771.
  • Wen SY, Chen JY, Weng YS, Aneja R, Chen CJ, Chih-Yang Huang, Kuo WW. Galangin suppresses H(2) O(2) -induced aging in human dermal fibroblasts. Environ Toxicol. 2017 Aug 18. doi: 10.1002/tox.22455.
  • Huang PC, Wang GJ, Fan MJ, Asokan Shibu M, Liu YT, Padma Viswanadha V, Lin YL, Lai CH, Chen YF, Liao HE, Chih-Yang Huang. Cellular apoptosis and cardiac dysfunction in STZ-induced diabetic rats attenuated by anthocyanins via activation of IGFI-R/PI3K/Akt survival signaling. Environ Toxicol. 2017 Aug 30. doi: 10.1002/tox.22460. (correspondence Author)
  • Tsai CY, Kuo WW, Shibu MA, Lin YM, Liu CN, Chen YH, Day CH, Shen CY, Viswanadha VP, Chih-Yang Huang. E2/ER β inhibit ISO-induced cardiac cellular hypertrophy by suppressing Ca2+-calcineurin signaling. PLoS One. 2017 Sep 1;12(9):e0184153. (correspondence Author)
  • Tzang BS, Liu CH, Hsu KC, Chen YH, Chih-Yang Huang, Hsu TC. Effects of oral Lactobacillus administration on antioxidant activities and CD4+CD25+forkhead box P3 (FoxP3)+ T cells in NZB/W F1 mice. Br J Nutr. 2017 Sep;118(5):333-342.
  • Chang CC, Chen CY, Chang GD, Chen TH, Chen WL, Wen HC, Chih-Yang Huang, Chang CH. Hyperglycemia and advanced glycation end products (AGEs) suppress the differentiation of 3T3-L1 preadipocytes. Oncotarget. 2017 Jul 5;8(33):55039-55050.
  • Hu WS, Rajendran P, Tzang BS, Yeh YL, Shen CY, Chen RJ, Ho TJ, Vijaya Padma V, Chen YH, Chih-Yang Huang. Lactobacillus paracasei GMNL-32 exerts a therapeutic effect on cardiac abnormalities in NZB/W F1 mice. PLoS One. 2017 Sep 21;12(9):e0185098. (correspondence Author)
  • Chang CC, Chen CY, Wen HC, Chih-Yang Huang, Hung MS, Lu HC, Chen WL, Chang CH. Caveolin-1 Secreted from Adipose Tissues and Adipocytes Functions as an Adipogenesis Enhancer. Obesity (Silver Spring). 2017 Nov;25(11):1932-1940.
  • Priya LB, Baskaran R, Chih-Yang Huang, Padma VV. Neferine ameliorates cardiomyoblast apoptosis induced by doxorubicin: possible role in modulating NADPH oxidase/ROS-mediated NFκB redox signaling cascade. Sci Rep. 2017 Sep 25;7(1):12283.
  • Yeh YL, Hu WS, Ting WJ, Shen CY, Hsu HH, Chung LC, Tu CC, Chang SH, Day CH, Tsai Y, Chih-Yang Huang. Erratum to: Hypoxia Augments Increased HIF-1a and Reduced Survival Protein p-Akt in Gelsolin (GSN)-Dependent Cardiomyoblast Cell Apoptosis. Cell Biochem Biophys. 2017 Oct 3. doi: 10.1007/s12013-017-0819-0. (correspondence Author)
  • Chen YF, Pandey S, Day CH, Chen YF, Jiang AZ, Ho TJ, Chen RJ, PadmaViswanadha V, Kuo WW, Chih-Yang Huang. Synergistic effect of HIF-1α and FoxO3a trigger cardiomyocyte apoptosis under hyperglycemic ischemia condition. J Cell Physiol. 2017 Oct 14. doi: 10.1002/jcp.26235. (correspondence Author)
  • Chang RL, Chang CF, Ju DT, Ho TJ, Chang TT, Lin JW, Le JC, Cheng SM, Day CH, Padma VV, Chih-Yang Huang. Short-term hypoxia upregulated Mas receptor expression to repress the AT(1) R signaling pathway and attenuate Ang II-induced cardiomyocyte apoptosis. J Cell Biochem. 2017 Oct 20. doi: 10.1002/jcb.26440. (correspondence Author)
  • Wen SY, Tsai CY, Pai PY, Chen YW, Yang YC, Aneja R, Chih-Yang Huang, Kuo WW. Diallyl trisulfide suppresses doxorubicin-induced cardiomyocyte apoptosis by inhibiting MAPK/NF-κB signaling through attenuation of ROS generation. Environ Toxicol. 2017 Oct 31. doi: 10.1002/tox.22500.
專書
  • (Wei-Wen Kuo) 、(Chung-jung Liu)、(Chun-Hsien Chu)、(Yi-jiun Weng)、(May-Hua Jen)、(Ming-Chin Lu)、(Fuu-jen Tsai)、(Chang-Hai Tsai) 、黃志揚(Chih-Yang Huang)* Traditional Chinese medicine on protection of heart function and cardiovascular system, 2008,3
  • (Yung-Ming Chang)、(Wei-Yi Chi)、(Edwin L. Cooper)、郭薇雯(Wei-Wen Kuo)、黃志揚(Chih-Yang Huang)*, Biology of Earthworms, 2011.1
  • (Chih-Yang Huang)、(Edwin L. Cooper)、(Catherine Fang-Yeu Poh)、(Wei-Wen Kuo) 、(Tung-Sheng Chen)、(Ronald Sherman) Evidence-based Complementary and Alternative Medicine, 2014
獲獎與榮譽
  • 中國醫藥大學 2006-2009-2012 傑出教授研究獎
  • 中國醫藥大學醫學院 96-101學年度(RPI, CJA及論文篇數)研究績優獎
  • 輔仁大學 營養科學系傑出系友獎 (2008, 第三屆Outstanding Alumni Award of Nutritional Science Department, Fu-Jen University, Taiwan)
  • 台中市建功國小立人中學傑出校友獎(2009)
  • 台灣陽明大學尹旬諾論文獎(第三屆)
  • 台灣調適醫學會理事(2007-2013)
  • Adaptive Medicine特約作者(2006-2009), 編輯委員(2009-2013)
  • 工研院生醫所無給職顧問(2009-2011)
  • 台中市莉程生物科技公司顧問(2006-2008)
  • 台中縣一品堂中醫體系科技顧問(2008迄今)
  • 台北市大冠生物科技公司顧問(2014迄今)
  • 2009生醫年會March 21-22, 24th,生理學Cardiovascular Biology Section, Program Organizer and invited speaker.
  • 2009 International Conference of Adaptive Medicine Society, Aug 2-5, Taipei: Organizing board member and invited speaker.
  • 中國西安交通大學暨附屬醫院參訪學者,2009年7月
  • 受邀擔任第七屆亞太生理學聯盟學術大會中醫藥替代醫學Satellite Symposium籌 備主席,
  • 2012年1月受邀埃及Mansoura大學訪問學者, invited speaker並擔任國際博士生Ehab Abdelfadil博士論文口試委員
  • 2013專門職業及技術人員高等考試營養師考試常設題庫小組命題技術研習會暨命題審查
  • 第29屆(2014)-生物醫學聯合學術年會海報複賽評審
  • 2014年11月受邀印度Bharathiar大學,Coimbatore訪問學者擔任博士生S. Kalaiselvi論文委員
  • 2015 International Conference of Adaptive Medicine Society (ISAM), May 27-30, Japan,Yonago: invited speaker.
專利
  • 益生菌株GM-080用於製備治療心臟發炎與心臟細胞凋亡之醫藥組合 中華民國 I406665 呂英震 謝豐欽 蔡政志 黃志揚 王雪芳 曾千育 景岳生物科技股份有限公司 2010.09-2030.09
  • PRODUCT CONTAINING ESTRACT FROM ZANTHOXYLUM AVICENNAE(LAM.) DC., AND PREPARATION PROCESS AND USE THE 美國 US 8,409,632 B2 黃志揚 劉哲育 陳德勇 中國醫藥大學 2011.08-2331.08
  • 鷹不泊的萃取物及其製備方法與用途 中華民國 99102417 黃志揚 劉哲育 陳德勇 中國醫藥大學 2013.09-2030.06
  • 發酵乳製品之用途/Use of Fermented Milk 中華民國 發明第 I 469736 蔡政志,黃志揚,林佩佩,謝尤敏 蔡政志,黃志揚,林佩佩,謝尤敏 2015.01-2030.06
  • 乳酸菌、其組合物與彼等於治療自體免疫疾病暨其併發症之用途 中華民國 10421222870 黃志揚 郭薇雯 曾博修 陳奕興 景岳生物科技股份有限公司 2015.09-2030
  • 乳酸菌、其組合物與治療自體免疫疾病及併發症的用途 中 國 CA104017746A 黃志揚 郭薇雯 曾博修 陳奕興 景岳生物科技股份有限公司 2015.09-2030.09
專題生
  • 大學部專題生:李碩宸(醫科生), 黃瀚澤, 曾健鈞, 劉昱賦
研究生
  • 臨床研究生:馮致中(博五), 林源泉(博四), 陳雅芳(博四), 黃佩真(博四), 傅建堯(博三), 劉益昇(博三), 陳仲豪(博二), 江瑞庭 (博二), 林親怡(博二), 游惠玲(博二), 何至菊(博一), 莊鶴麟(博一) , 何至菊(博一), 莊鶴麟(博一)
  • 本地基礎研究生:蘇易辰(博三) ,邱致豪(博二), 王添德(博一) ,蔡季鋼(博一), 何文昆(研二) , 林立勳(研二), 黃祥晏(研二), 陳凱立(研一), 賴聰明(研一), 林伯萱(研一), 倪彥婷(研一), 許淵聖(研一)
  • 外籍研究生:Dr. Ehab Abd( Assistant Professor, Mansoura University 埃及), Stanley DUMEUS(海 地), , Sudhir Pandey(印度), Kannathasan.T (印度), Parthasarathi Barik(印度) ,Tran Thanh Viet (越南), Le Thi Ly (越南), Nguyen Hoang Anh Kha (越南) , Le Chi Cong(越南) , Le Thi Hang Nga(越南),Nguyen Trong Khiet(越南), Lawrence Marte (美國),Do Chi Nhna(越南), Ayaz Ali(巴基斯坦),黃襄川(馬來西亞)
  • 研究助理:陳佳琦, 廖慧珍, 張育郡, 曾嚴審, 陳俊瑋, 張書豪, 施惠儂, 朱芫緣, 藍智, 葉峻安, AGARWAL SAKSHI(印度), MANVI SUNDER(印度)
  • 博士後研究:MARTHANDAM ASOKAN SHIBU博士, Tamilselvi Shanmugam博士, Sivalingam Kalaiselvi博士, KHAN FARHEEN BADREALAM博士, SRINIVASAN NITHIYANANTHAM博士, 廖柏翔博士, 陳佳宜, 洪孟愉, 陳佳華, 林菁薇
  • 研究員:陳冬生博士(中國附醫), 黃智洋博士(中國附醫), 劉哲育博士(清遠醫院-顧問) , 丁韋仁博士(清遠醫院-中心主任), 陳怡君博士(清遠醫院), 鄭立豪博士(清遠醫院)
指導研究生論文獲獎
  • 19th (劉忠榮)& 21th (朱俊憲)生醫年會生化分生優秀壁報獎, 23th (郭昱均)生醫年會生理學優秀壁報獎
  • 3rd中正大學分生所論文獎1st名(王惠勵), 1rd中山醫學大學生化所論文獎1st名(顏均宇), 1rd中國醫藥大學國際生醫研討暨研究生發表會壁報獎1st名(顏均宇), 1rd中國醫藥大學生科所研究生發表會壁報獎1st名(李振宇)
  • 2009 International Conference of Adaptive Medicine Society, 發表壁報獎1st名(陳德勇,越南籍生)
  • 第27屆(2012年)生醫聯合學術年會壁報論文競賽生化分生組獲得優勝(賴益平)
  • 第28屆(2013年)生醫聯合學術年會看板論文競賽生理組榮獲第三名(林依霖); 生化分生組優秀壁報獎(陳佳華,劉俊宏)
  • 第29屆(2014年)生醫聯合學術年會看板論文競賽生化分生組優秀壁報獎(黃智洋,丁韋仁) 中華民國毒物學學會佳作(魏妤珉)
  • 第30屆(2015年)生醫聯合學術年會看板論文競賽生化分生組佳作獎(黃智洋)
  • 第30屆(2015年)生物醫學聯合學術年會中國生理學會海報論文競賽榮獲第三名(廖柏翔)
  • 第30屆(2015年)生物醫學聯合學術年會中國生理學會口頭論文競賽榮獲傑出論文獎(廖柏翔);
  • 第30屆(2015年)生物醫學聯合學術年會中國生理學會口頭論文競賽榮獲佳作獎(Sarnai)
  • 第30屆(2015年)生物醫學聯合學術年會中華民國毒物學學會海報論文競賽榮獲佳作(丁韋仁,楊珮禎)
  • 第八屆亞洲大學暨中國醫藥大學生物科技暨食品安全研討會壁報論文競賽獲得特優獎(劉炤榮)
  • 第九屆亞洲大學暨中國醫藥大學生物科技暨食品安全研討會壁報論文競賽獲得特優獎(李法倫) 優等獎(陳翊瑋) 口頭報告競賽獲得佳作獎(曾仁佑)
  • 第31屆(2016年)生物醫學聯合學術年會中國生理學會海報論文競賽佳作獎(黃琪雯)
  • 第31屆(2016年)生物醫學聯合學術年會台灣生物學會優秀壁報論文獎 (廖柏翔)
  • 指導學生林聖全獲獎學金60萬至美國喬治亞大學交換一年
  • 指導學生莊授媖獲獎學金60萬至美國南加州大學交換一年
  • 指導學生廖柏翔獲菁英博士殊榮並獲獎學金40萬以及二年二百萬至美國Wake Forest University大學交換
  • 導學生林士尹獲獎學金60萬至德國慕尼黑大學交換一年
  • 指導學生蘇易辰獲國際共同人才培育計畫殊榮並獲獎學金每年一百五十萬元至美國加州大學交換二年
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