呂水淵　(Sue-Yen Lu)

Tel: (04) 2330 - 2101 ext 505

FAX: (04) 2332 - 3073

E-MAIL ADDRESS :lusueyen@tactri.gov.tw

　

*學經歷(Education and Professional experience)：

學歷
  • 1982~1986: 私立東海大學畜產學系畢業
  • 1989~1991: 私立東海大學畜產學系研究所碩士班畢業
  • 1999~ 2006: 國立臺灣大學醫學院毒理學研究所博士班畢業
經歷
  • 1986~1988: 服役海運陸戰隊

    　

  • 1988~1989: 任職財團法人臺灣養殖科學研究所 ( 現已更名為動物科技研究所 ) 傳生理系國科會計畫助理

    　

  • 1991~1992: 任職臺灣省畜產試驗所新化總所生理系國科會計畫助理

    　

  • 1992~1993: 通過全國性公務人員高等考試及格分發臺灣省農業藥物毒物試驗所委任助理

    　

  • 1993~1997: 任職臺灣省農業藥物毒物試驗所應用毒理組薦任助理

    　

  • 1998~ 目前 : 任職臺灣省農業藥物毒物試驗所應用毒理組薦任助理研究員

    　

　

*專長：

  1. 畜產學
  2. 毒理學
  3. 哺乳動物生殖生理學
  4. 哺乳動物生殖毒理學
  5. 哺乳動物胚胎學
　

　

*負責工作(Major research field)：

  1.   藥物對溫血動物之毒理試驗
  2.   藥物上巿登記毒理測試資料中後代繁殖毒性與致畸胎性測試
  3.   藥物上巿登記毒理測試資料中基因毒性測試
  4.   殺鼠劑藥效委託試驗
  5.   野鼠防除技術之研究
  6.   農藥新申請上巿登記毒理審查工作
  7.   藥物對溫血動物生殖毒理作用機制之探討
　

*目前及未來研究領域

  1.   藥物對溫血動物生殖毒理與荷爾蒙干擾作用機制之研究
  2.   藥物對溫血動物基因毒理之研究
  3.   野鼠防除技術之研究

　

*研究成果：

(A)期刊論文(Publication)：

    1. 呂水淵、楊德威、李坤雄、劉世華、王家宇。 1992. 短暫舒解熱緊迫對荷蘭女牛受胎率和生殖內泌素之影響。中國畜牧學會會誌 21 ： 369-383.
    2. 王家宇、呂水淵、胡淵欽、楊德威。 1993. 夏季冷卻處理對荷蘭母牛泌乳及生殖性狀之影響。中國畜牧學會會誌 22 （ 2 ）： 163-173.
    3. 王家宇、楊德威、楊忠亮、呂水淵。 1995. 預先餵飼盤固乾草對早泌乳牛葉炎發生率之影響。中國畜牧學會會誌 24 (3): 311-328.
    4. 呂水淵、林宏偉、王順成。 1995. 氨基甲酸鹽農藥免賴得（ Benomyl ）對大鼠胚胎畸形性之探討。中華民國獸醫學會會誌 20 （ 4 ）： 348-356.
    5. 呂水淵、林宏偉、王順成。 1995. 殺菌劑貝芬替（ Carbendazim ）對鼠致胚胎畸形性評估。植保會刊 37 ： 331-338.
    6. 呂水淵、王順成。 1996. 五種農藥對大鼠子代外觀畸形與骨骼之影響。中華民國獸醫學會會誌 22 （ 6 ）： 402-412.
    7. 呂水淵、王順成。 1998. 甲氧基護谷與 2,4- 地除草劑誘發大鼠子代外觀、細部骨骼及內臟異常性評估。中華民國獸醫學會會誌 24 （ 1 ） : 29-41.
    8. 呂水淵、王順成。結構相似之免賴得與甲基多保淨農藥誘發大鼠畸形 性之比較。台灣畜牧獸醫學會會報 67 （ 3-4 ） : 161-171,1997.
    9.   呂水淵、王順成。農藥免賴得致胚胎畸形及其測試方法之建立。中華民國獸醫學會會誌 25 （ 1 ） : 69-76, 1999
    10. 呂水淵、王順成。三種農用藥劑對小鼠精子活力、體外受精率及胚胎發育之影響。中華民國獸醫學會會誌 , 26(1): 24-35, 2000.
    11.   Lu S . Y . , Liao J . W . , Kuo M . L . , Wang S . C . , Hwang J . S . , Ueng T . H. ( 200 4) Endocrine-disrupting activity in carbendazim-induced reproductive and developmental toxicity in rats. Journal of Toxicology and Environmental Health Part A , 67, 1501-1515.
    12.   Lu S. Y., Liao J. W., Kuo M. L., Hwang J. S., and Ueng T. H. (2006) Antagonistic and synergistic effects of carbendazim and flutamide exposures in utero on reproductive and developmental toxicity in rats. Journal of Food and Drug Analysis 14, 120-132
    13. Chan P. K., Lu S. Y., Liao J. W., Wei C. F., Tsai Y. Y., and Ueng T. H. (2006) Induction and inhibition of cytochrome P450-dependent monoxygenases of rats by fungicide bitertanol. Food and Chemical Toxicology 44(12) , 2047-2057

      　

    (B)研討會論文

      1. 楊天樹、呂水淵、劉世華、黃華淦。 1992. 豬肉外觀特徵與活體和屠體性狀間的典型相關。中國畜牧學會會誌 21 （增刊）： 38.
      2. 楊天樹、劉世華、呂水淵。 1990. 豬隻生長成績和屠體性狀的差異對肉質外觀特徵的影響。中國畜牧學會會誌 19 （增刊）： 30
      3. 楊天樹、劉世華、呂水淵。 1989. 利用活體交換氫含量來預估肉豬屠體肥瘦的可行性。中國畜牧學會會誌 18 （增刊）： 20
      4. 許登造、黃文瑛、呂水淵。 1992. 利用分切法去除水牛體外成熟卵核之複殖方法研究。中國畜牧學會會誌 21 （增刊）： 41.
      5. 劉世華、李坤雄、楊天樹、呂水淵、李惠玲。 1992. 女豬性成熟生殖指標之探討。中國畜牧學會會誌 21 （增刊）： 46.
      6. 許登造、黃文瑛、呂水淵。 1992. 小鼠單細胞期胚之急速玻璃化冷凍保存。中國畜牧學會會誌 21 （增刊）： 125.
      7. 呂水淵、楊德威、李坤雄、劉世華、王家宇。 1992. 短暫舒解熱緊迫對荷蘭女牛受胎率和生殖內泌素之影響。中國畜牧學會會誌 20 （增刊）： 29.
      8. 廖俊旺、蔡三褔、呂水淵、鄭幼文、劉興華、康照洲、龐飛、王順成。 1997. The lethal effect of cartap via eye toxicity study in rabbits. The First International Conference of Asian Sociey of Toxicology. Japan , Post No. 163, pp. 201.
      9. 呂水淵、王順成。 1997. The teratologic relationship among external, skeletal and visceral abnormality induced by different pesticides in rats. The Twelfth Joint Annual Conference of Biomedical Sciences. R.O.C. pp.189
      10. 呂水淵、王順成。 1998. The foundation of an approach to the reproductive toxicity and effect of three pesticides on in vitro fertilization in mice. 中華植物保護學會暨中華民國植物病理學會民國八十七年聯合年會 . pp.25
      11. 王順成、呂水淵、廖俊旺、黃振聲、黃禹萍、郭明良、翁祖輝。 2000. 台灣主要農藥荷爾蒙化合物生物檢定法。 89 年中日環境荷爾蒙學術研討會： 38-42.
      12. 呂水淵、王順成。 2000. 農藥環境荷爾蒙劑之毒性評估。 ‘ 第一屆環境荷爾蒙與持久性有機污染物研討會。 pp113-124
      13. Lu SY, Wang SC, Ueng TH, Kuo ML. The possible teratogenic mechanism of benomyl in Wistar rats. Harmonization of pesticide management –regulation, monitoring and evaluation. IUPAC-TACTRI /COA international Workshop on Pesticides 2000.
      14. Lu SY, Liao JW, Wang SC, Hwang JS, Kuo ML, Ueng TH. 200 1 . Effects of benomyl on testicular toxicity and androgen receptor of Wistar rats. The Sixteenth Joint Annual Conference of Biomedical Science, p74.
      15. Lu SY, Liao JW, Wang SC, Hwang JS, Kuo ML, Ueng TH. 200 2 . Endocrine-disrupting activity of carbendazim in rats. The Seventeenth Joint Annual Conference of Biomedical Science, p77 .
      16. Lu SY, Liao JW, Wang SC, Hwang JS, Kuo ML, Ueng TH. 200 3 . Developmental toxicity and endocrine-disrupting activity of carbendazim of in utero exposed, ovariectomized or castrated rats. The Eighteen Joint Annual Conference of Biomedical Sciences, p62.
      17. Lu, S. Y., Liu, C. Y., Hwang, J. S., and Wang, S. C. 2003. Studies on the reproductive toxicity induced by plant growth regulator in rats. Annual Meeting of Plant Protection Society of the Republic of China . P 17.
      18. Lu SY, Liao JW, Wang SC, Hwang JS, Kuo ML, Ueng TH. 200 4 . Roles of endocrine-disrupting activity in the reproductive toxicity of carbendazim in rats. The 3 rd International Congress of the Asian Society of Toxicology February 1-6, Thailand , p 49.
      19. Lu SY, Kuo ML, Wang SC, Hwang JS, Ueng TH. 200 4 . Roles of endocrine-disrupting activity in the prevention of carbendazim-induced implantation loss and reproductive toxicity by flutamide in rats in utero exposure. The Nineteenth Joint Annual Conference of Biomedical Sciences, p350.
      20. Lu, S. Y., Tsai, M. C., Liu, C. Y., Hou, C. Y., Sung, K. C., Hwang, J. S., and Wang, S. C. 2004. Studies on the reproductive toxicity of pesticides with structural activity relationship in rats. The Union Annual Meeting of Plant Protection Society of the Republic of China and Insect Society of Taiwan . P7( 植保 -PT-19).
      21. Lu SY, Liao JW, Liu CY, Tsai MC, Hou CY, Sung KC, Hwang JS and Wang SC. 2004. Androgen receptor expression in carbendazim-induced reproductive and developmental toxicity in rats. The 8 th membership meeting of Chinese Society of Laboratory Animal Sciences. 51(No.PT -17).
      22. Lu SY * , Chen MC, Wu JY, Lin JC, Yu CY. Hwang JS. 2005. Effects of in utero carbendazim and benomyl exposures on reproductive development in male and female rats. The Union Annual Meeting of Plant Protection Society of the Republic of China and Insect Society of Taiwan . P7( 植保 -4A -16).pp13.
      23. Lu SY * , Chen MC, Wu JY, Lin JC, Yu CY. Hwang JS. 2005. Gene and protein expression of androgen receptor in carbendazim-induced endocrine-disrupting activity in male rats. The Eighth Chinese Society of Laboratory Animal Sciences (PT-31), pp68.
      24. Shui-Yuan Lu 1,3* , Jiann-Yih Wu 1 , Min-Chen Chen 1 , Jiann-Chih Lin 1 , Chien-Yi Yu 1 , Jiunn-Wang Liao 2 , Jenn-Sheng Hwang 1 and Tzuu-Huei Ueng 3# . 2006. GENE EXPRESSION OF ANDROGEN RECEPTOR IN CARBENDAZIM-INDUCED ENDOCRINE-DISRUPTING ACTIVITY IN MALE RATS. The Twentieth Joint Annual Conference of Biomedical Sciences, pp238
      25. Shui-Yuan Lu 1,3* , Jiann-Yih Wu 1 , Min-Chen Chen 1 , Jiann-Chih Lin 1 , Chien-Yi Yu 1 , Jiunn-Wang Liao 2 , Jenn-Sheng Hwang 1 and Tzuu-Huei Ueng 3# . 2006. PROTECTION OF ANDROGENIC CARBENDAZIM AGAINST DEVELOPMENTAL AND REPRODUCTIVE TOXICITY OF FLUTAMIDE IN MALE AND FEMALE RATS. The Twentieth Joint Annual Conference of Biomedical Sciences, pp238

        　
      26. Lu SY*, Chen MC, Wu JY, Chu YT, Wu ST, Fan HC, Wang JB, and Hwang JS. 2006. Structural activity relationship of reproductive toxicity and endocrine disrupting activity induced by pesticides in rats. The Ninth Chinese Society of Laboratory Animal Sciences (PT-11), pp. 65

        　
      27. 外來嚙齒類寵物之調查 － 范杏淳，王建彬，盧高宏，陳敏貞，吳建毅，邱怡翠，伍書亭，黃振聲，呂水淵 (行政院農業委員會農業藥物毒物試驗所) Investigating on the pet rodent imported from the outside Taiwan－ Fan, H. C. , Wang, J. B., Lu, K. H., Chen, M. C., Wu, J. Y., Chu, Y. T., Wu, S. T., Hwang, J. S., and Lu, S. Y. The Union Annual Meeting of Plant Protection Society of the Republic of China and Plant Pathology Society of the Republic of China . PT-09(植保-).pp.

        　
      28. 緬甸小鼠對農作物之危害與食性調查－王建彬，范杏淳，盧高宏，陳敏貞，吳建毅，邱怡翠，伍書亭，黃振聲，呂水淵 (行政院農業委員會農業藥物毒物試驗所) Investigating on the food habits and crop damage of Rattus exulans in eastern Taiwan － Wang, J. B., Fan, H. C. , Lu, K. H., Chen, M. C., Wu, J. Y., Chu, Y. T., Wu, S. T., Hwang, J. S., and Lu, S. Y. The Union Annual Meeting of Plant Protection Society of the Republic of China and Plant Pathology Society of the Republic of China . PT-08(植保-).pp.

        　
      29. 荷爾蒙干擾化合物對雄大鼠雄性素受體基因表現影響之化學結構相關性 － 陳敏貞，吳建毅，邱怡翠，伍書亭，王建彬，范杏淳，黃振聲，呂水淵 (行政院農業委員會農業藥物毒物試驗所) Gene expression of androgen receptor in chemical-induced endocrine-disrupting activity based on structure-activity relationship in male rats －Chen, M. C., Wu, J. Y., Chu, Y. T., Wu, S. T., Wang, J. B., Fan, H. C. , Hwang, J. S., and Lu, S. Y. The Union Annual Meeting of Plant Protection Society of the Republic of China and Plant Pathology Society of the Republic of China . PT-07(植保-).pp.

        　
      30. M. C. Chen*, J. Y. Wu, Y. T. Chu, S. T. Wu, J. B. Wang, H. C. Fan, J. S. Hwang, S. Y. Lu# . 2007. STRUCTURAL ACTIVITY RELATIONSHIP OF REPRODUCTIVE TOXICITY AND ENDOCRINE-DISRUPTING ACTIVITY INDUCED BY PESTICIDES IN RATS. The Twenty Second Joint Annual Conference of Biomedical Sciences, pp

        　
      31. J. Y. Wu*, M. C. Chen, Y. T. Chu, S. T. Wu, J. B. Wang, H. C. Fan, J. S. Hwang, S. Y. Lu# . 2007. STUDIES ON THE MRNA AND PROTEIN EXPRESSION OF ANDROGEN RECEPTOR IN CHEMICAL-INDUCED ENDOCRINE-DISRUPTING ACTIVITY BASED ON STRUCTURE-ACTIVITY RELATIONSHIP IN RATS. The Twenty Second Joint Annual Conference of Biomedical Sciences, pp