CURRICULUM VITAE

Name: Chih-Ping Chen

Sex: Male

Date of Birth: June 23, 1953

Nationality: Taiwan

Correspondence: Mackay Memorial Hospital

92, Section 2, Chung-Shan North Road, Taipei, Taiwan

Tel: (02)-2543 3535; Fax: (02)-2543 3642

Email: cpc_mmh@yahoo.com

Specialty: Obstetrics and Gynecology, Perinatology, Dysmorphology, and Clinical Genetics

Education: 1979, Doctor of Medicine, School of Medicine, Kaohsiung Medical University

Experiences:

1981-1984 Resident, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan

1988-1989 Postdoctoral fellowship, Department of Genetics, Yale University, U.S.A.

1985-present Attending Physician, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan

1997-present Director, Division of Perinatal Genetics, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan

2003-2004 President, Taiwan Society of Perinatology

2006-present Chairman, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan

Academic Appointments:

1998-2004 Associate Professor, National Yang-Ming University, Taipei, Taiwan

2004-present Professor, National Yang-Ming University, Taipei, Taiwan

Professor, China Medical University, Taichung, Taiwan

Professor, Yuanpei University of Science and Technology, Hsinchu, Taiwan

Editor-in-Chief: Taiwanese Journal of Obstetrics and Gynecology

Editor: Chinese Journal of Medicine

Reviewer: Acta Paediatrica

American Journal of Obstetrics and Gynecology

Archives of Gynecology and Obstetrics

BMC Medical Genetics

BMC Pregnancy

Clinical Genetics

Clinical Chemistry and Laboratory Medicine

Clinical Medicine & Research

European Journal of Pediatrics

Fertility and Sterility

Journal of the Chinese Medical Association

Journal of the Formosan Medical Association

Prenatal Diagnosis

The Journal of Obstetrics and Gynecology Research

Ultrasound in Obstetrics and Gynecology

First-authored Publications:

1. Prenatal diagnosis of omphalocele associated with umbilical cord cyst. Acta Obstet Gynecol Scand 1995; 74: 832-5.

2. Echo-guided lymphatic drainage by fine needle aspiration in persistent isolated septated fetal nuchal cystic hygroma. Fetal Diagn Ther 1996; 11: 150-3.

3. Prenatal diagnosis of partial monosomy 3p and partial trisomy 2p in a fetus associated with shortening of long bones and a single umbilical artery. Prenat Diagn 1996; 16: 270-5.

4. Prenatal detection of the separation of the great toe, toe syndactyly and large bilateral choroid plexus cysts in a fetus with trisomy 18. Am J Perinatol 1996; 13: 203-5.

5. Cytogenetic evaluation of cystic hygroma associated with hydrops fetalis, oligohydramnios or intrauterine fetal death: the roles of amniocentesis, postmortem chorionic villus sampling and cystic hygroma paracentesis. Acta Obstet Gynecol Scand 1996;75: 454-8.

6. CVS-exposed limb reduction defects with or without other birth defects: presentation of six cases born during a period of 9 years. Am J Med Genet 1996; 63: 447-53.

7. Ultrasound-guided fluid aspiration and prenatal diagnosis of duplicated hydrometrocolpos with uterus didelphys and septate vagina.

Prenat Diagn 1996; 16: 572-6.

8. Partial duplication of 3q and distal deletion of 11q in a stillbirth with an omphalocele containing the liver, short limbs, and intrauterine growth retardation. J Med Genet 1996; 33: 615-7.

9. Prenatal diagnosis of partial monosomy 13q associated with occipitalital encephalocoele in a fetus. Prenat Diagn 1996; 16: 664-6.

10. Prenatal diagnosis and perinatal aspects of abdominal wall defects. Am J Perinatol 1996; 13: 355-61.

11. A case of achondrogenesis type IA with an occipital encephalocele. Genet Counsel 1996; 7: 193-6.

12. A concealed penis mimicking penile agenesis in an infant with trisomy 13 . Clin Genet 1996; 50: 156-8.

13. Prenatal diagnosis of terminal deletion 7q and partial trisomy 3p in fetuses with holoprosencephaly. Clin Genet 1996; 50: 321-6.

14. Prenatal diagnosis of asphyxiating thoracic dyaplasia (Jeune syndrome). Am J Perinatol 1996;13: 495-8.

15. Prenatal diagnosis of supernumerary der(22)t(11;22) associated with the Dandy-Walker malformation in a fetus. Prenat Diagn 1996; 16: 1137-40.

16. In utero urinary bladder perforation, urinary ascites and bilateral contained urinomas secondary to posterior urethral valves: clinical and imaging findings. Pediatr Radiol 1997; 27: 3-5.

17. First report of distal obstructive uropathy and prune-belly syndrome in an infant with amniotic band syndrome. Am J Perinatol 1997; 14: 31-3.

18. Progressive fetal axillary cystic lymphangioma with coexistent naevus flammeus. Brit J Dermatol 1997; 136: 102-4.

19. Prenatal diagnosis, pathology, and genetic study of fetus in fetu. Prenat Diagn 1997; 17: 13-21.

20. Cutis marmorata telangiectatica congenita associated with an elevated maternal serum human chorionic gonadotrophin level and transitory isolated fetal ascites. Brit J Dermatol 1997; 136: 267-71.

21. Cebocephaly, alobar holoprosencephaly, spina bifida and sirenomelia in a stillbirth. J Med Genet 1997; 34: 252-5.

22. Skeletal deformities of acardius anceps: the gross and imaging features. Pediatr Radiol 1997; 27: 221-5.

23. Prenatal diagnosis of cephalothoracopagus janiceps monosymmetros. Prenat Diagn 1997; 17: 384-8.

24. Type III congenital cystic adenomatoid malformation of the lung detected through maternal serum screening positive for Down’s syndrome. Acta Obstet Gynecol Scand 1997; 76: 378-9.

25. Perinatal features of Omphalocele-Exstrophy-Imperforate anus-Spinal defects (OEIS complex) associated with large meningomyeloceles and severe limb defects. Am J Perinatol 1997; 14: 275-9.

26. Prenatal diagnosis of a deletion of 18q in a fetus associated with multiple-maker screen positive results. Prenal Diagn 1997; 17: 571-6.

27. Prenatal diagnosis of partial trisomy 12 and partial trisomy 21 due to a 3:1 segregation of maternal reciprocal translocation t(12;21)(p13.3;q21). Prenat Diagn 1997; 17: 675-80.

28. Clinical and perinatal sonographic features of congenital adrenal cystic neuroblastoma: a case report with review of the literature. Ultrasound Obstet Gynecol 1997; 10: 68-73.

29. Prenatal diagnosis of de novo proximal interstitial deletion of 14q associated with cebocephaly. J Med Genet 1997; 34: 777-8.

30. Recurrent omphalocele with partial trisomy 3q and partial monosomy 11q. Clin Genet 1997; 52: 196-8.

31. Pregnancy with concomitant chorangioma and placental vascular malformation with mesenchymal hyperplasia. Hum Reprod 1997; 12: 2553-6.

32. Maternal serum screening abnormality in a fetus associated with arthrogryposis multiplex congenita and amyoplasia. Prenat Diagn 1997; 17: 1187-90.

33. Kyphomelic dysplasia in two sib fetuses. J Med Genet 1998; 35: 65-9.

34. In utero adrenal hemorrhage: clinical and imaging findings. Acta Obstet Gynecol Scand 1998; 77: 239-41.

35. Prenatal diagnosis of de novo isochromosome 13q associated with microcephaly, alobar holoprosencephaly and cebocephaly in a fetus. Prenat Diagn 1998; 18: 393-8.

36. Sonographic findings in a fetus with megacystis-microcolon-intestinal hypoperistalsis syndrome. J Clin Ultrasound 1998; 26: 217-20.

37. Enlarged cisterna magna in the third trismester as a clue to fetal trisomy 18. Fetal Diagn Ther 1998; 13:29-34.

38. Prenatal detection of human cytomegavirus DNA in fetal ascites by the polymerase chain reaction. Acta Obstet Gynecol Scand 1998; 77: 466-7.

39. Prenatal diagnosis of de novo interstitial 16q deletion in a fetus associated with sonographic findings of prominent coronal sutures, a prominent frontal bone and shortening of the long bones. Prenat Diagn 1998; 18, 490-5.

40. Sirenomelia with uncommon osseous fusion associated with neural tube defect. Pediatr Radiol 1998; 28:293-6.

41. Concomitant chyloperitoneum and omental cysts presenting as fetal ascites with intra-abdominal cysts on prenatal ultrasound. Prenat Diagn 1998; 18: 984-5.

42. Isochromosome 18q in a fetus with congenital megacystis, intrauterine growth retardation and cloacal dysgenesis sequence. Prenat Diagn 1998, 18: 1068-74.

43. Favorable outcome in a fetus with an extensive cystic hygroma colli and intralesional hemorrhage. Am J Perinatol 1998; 15: 601-5.

44. Ileal penetration by a Multiload-Cu 375 intrauterine contraceptive device: a case report with review of the literature. Contraception 1998; 58:295-304.

45. Perinatal findings in a male fetus associated with congenital megacystis and anorectal malformations. Fetal Diagn Ther 1998; 13: 348-51.

46. De novo unbalanced translocation resulting in monosomy for proximal 14q and monosomy for distal 4p in a fetus with intrauterine growth retardation, Wolf-Hirschhorn syndrome, hypertrophic cardiomyopathy and partial hemihypoplasia. J Med Genet 1998; 35: 1050-3.

47. Partial trisomy 8q and partial monosomy 15q in a fetus with hydrocephalus, congenital heart defect and kyphoscoliosis. Prenat Diagn 1998; 18: 1289-93.

48. Androgen receptor gene mutations in 46,XY females with germ cell tumors. Hum Reprod 1999, 14: 664-70.

49. Bilateral renal agenesis and fetal ascites in association with partial trisomy 13 and partial trisomy 16 due to a 3:1 segregation of maternal reciprocal translocation t(13;16)(q12.3;p13.2). Prenat Diagn 1999; 19: 783-6.

50. A frameshift mutation in the DNA-binding domain of androgen receptor gene associated with complete androgen insensitivity, persistent müllerian structures and germ cell tumors in dysgenetic gonads. Fertil Steril 1999; 72: 170-3.

51. Inconsistency of omphalocele contents in three consecutive siblings with partial trisomy 3q and partial monosomy 11q. Prenat Diagn 1999; 19: 591.

52. Prenatal diagnosis of a fetus with distal 10q trisomy. Prenat Diagn 1999; 19: 876-8.

53. Congenital cervical cystic hygroma causing an airway emergency. Am J Emerg Med 1999; 17: 622-4.

54. Prenatal diagnosis of partial trisomy 3p (3p23®pter) and monosomy 7q (7q36®qter) in a fetus with microcephaly, alobar holoprosencephaly and cyclopia. Prenat Diagn 1999; 19: 986-9.

55. Adnexal torsion during late pregnancy. Am J Emerg Med 1999; 17: 738-9.

56. Prenatal diagnosis of bilateral ventriculomegaly and an enlarged cisterna magna in a fetus with partial trisomy 9 and partial trisomy 21. Prenat Diagn 1999; 19: 1175-80.

57. Prenatal diagnosis of cystic bladder distension secondary to obstructive uropathy. Prenat Diagn 2000; 20: 260-3.

58. A fetus with VACTERL association, unilateral aplasia of humerus and partial hemihypoplasia. Clin Dysmorphol 2000; 9: 147-8.

59. Rapid determination of zygosity and common aneuploidies from amniotic fluid cells using quantitative fluorescent polymerase chain reaction following genetic amniocentesis in multiple pregnancies. Hum Reprod 2000; 15: 929-34.

60. Fetal DNA in maternal plasma: the prenatal detection of a paternally inherited fetal aneuploidy. Prenat Diagn 2000; 20: 355-7.

61. Rapid diagnosis and treatment of postcesarean parametrial abscess by transabdominal ultrasound-guided needle aspiration. Ultrasound Obstet Gynecol 2000;15: 343-4.

62. Prenatal diagnosis of inherited satellited non-acrocentric chromosomes. Prenat Diagn 2000; 20: 384-9.

63. Hamartoma in a pubertal patient with complete androgen insensitivity syndrome and R(831)X mutation of the androgen receptor gene. Fertil Steril 2000; 74: 182-3.

64. Prenatal diagnosis and genetic analysis of double trisomy 48,XXX,+18. Prenat Diagn 2000; 20: 750-3.

65. Prenatal diagnosis and genetic analysis of X-chromosome polysomy 49,XXXXY. Prenat Diagn 2000; 20: 754-7.

66. A digynic triploid fetus presenting intrauterine growth restriction, severe oligohydramnios and relative macrocephaly on prenatal ultrasound. Ultrasound Obstet Gynecol 2000; 16: 291-2.

67. Cytogenetic discrepancy between fetal tissue and body fluid in a fetus with cystic hygroma colli. Prenat Diagn 2000;20: 933-4.

68. Prenatal diagnosis of limb-body wall complex using two-dimensional and three-dimensional ultrasound. Prenat Diagn 2000; 20: 1020.

69. Severe terminal transverse limb reduction defects in homozygous Southeast-Asian a-thalassemia-1. Clin Dysmorphol 2001; 9: 71-3.

70. Prenatal diagnosis of partial trisomy 3q(3q22®qter) and monosomy 6q(6q25.3®qter) in a fetus with sonographic findings of cystic hygroma colli and unilateral pleural effusion. Prenat Diagn 2001; 21: 73.

71. Prenatal diagnosis and genetic analysis of type I and type II thanatophoric dysplasia. Prenat Diagn 2001; 21: 89-95.

72. Prenatal diagnosis of mosaic ring chromosome 13 with anencephaly. Prenat Diagn 2001; 21: 102-5.

73. Ultrasound-guided needle aspiration of fetal choledochal cyst. Ultrasound Obstet Gynecol 2001; 17: 175-6.

74. Multiple globules in a cystic ovarian teratoma. Fertil Steril 2001; 75: 618-9.

75. Second-trimester molecular diagnosis of a heterozygous 742C®T (R248C) mutation in FGFR3 gene in a thanatophoric dysplasia variant following suspicious ultrasound findings. Ultrasound Obstet Gynecol 2001; 17: 272-3.

76. First-trimester sonographic demonstration of a mobile cranial cyst associated with anencephaly and amniotic band sequence. Ultrasound Obstet Gynecol 2001; 17: 360-1.

77. Prenatal diagnosis of de novo distal 11q deletion associated with sonographic findings of unilateral duplex renal system, pyelectasis and orofacial cleft. Prenat Diagn 2001; 21: 317-20.

78. Prenatal diagnosis of partial monosomy 18p (18p11.2®pter) and trisomy 21q (21q22.3®qter) with alobar holoprosencephaly and premaxilary agenesis. Prenat Diagn 2001; 21: 346-50.

79. Prenatal diagnosis of limb-body wall complex with craniofacial defects, amniotic bands, adhesions and upper limb deficiency. Prenat Diagn 2001; 21: 418-9.

80. Fetal DNA analyzed in plasma from a mother’s three consecutive pregnancies to detect paternally inherited aneuploidy. Clin Chem 2001; 47: 937-9.

81. Sonographic detection of a previously unsuspected vesical endometriosis in a woman with a symptom of dysmenorrhea. Ultrasound Obstet Gynecol 2001; 18; 183-4.

82. Resolution of fetal bilateral chylothorax and ascites after two unilateral thoracenteses. Ultrasound Obstet Gynecol 2001; 18: 401-2.

83. Use of the hemostatic multiple square suturing of the uterus for control of massive postcesarean section hemorrhage and preservation of fertility. Acta Obstet Gynecol Scand 2001; 80: 976.

84. Short rib-polydactyly syndrome type III (Verma-Naumoff) in a third-trimester fetus with unusual associations of epiglottic hypoplasia, renal cystic dysplasia, pyelectasia and oligohydramnios. Prenat Diagn 2001; 21: 1101-2.

85. Molecular diagnosis of a novel heterozygous 268C®T (R90C) mutation in the homeodomain of TGIF gene in a fetus with holoproscencephaly and premaxillary agenesis. Prenat Diagn 2002; 22: 5-7.

86. Three-dimensional ultrasound evaluation of complex anomalies associated with fetal ventral midline defects. Ultrasound Obstet Gynecol 2002; 19: 102-4.

87. Fetal cervico-mediastinal cystic hygroma associated with maternal serum screening positive for Down syndrome. Prenat Diagn 2002; 22: 166.

88. Sonographic appearance of the uterus after simple square suturing for rapid control of postpartum hemorrhage and preservation of fertility. J Clin Ultrasound 2002; 30: 189-91.

89. Prenatal sonographic diagnosis of median facial cleft should alert holoprosencephaly with premaxillary agenesis and prompt genetic investigation. Ultrasound Obstet Gynecol 2002; 19: 421-2.

90. Sonographic findings in a case of congenital pyloric diaphragm. Ultrasound Obstet Gynecol 2002; 19; 528-9.

91. Bilateral calcified ovarian fibromas in a patient with Sotos syndrome. Fertil Steril 2002; 77: 1285-7.

92. Sonographic detection of situs inversus totalis, ventricular septal defect, and short rib-polydactyly syndrome type III (Verma-Naumoff) in a second-trimester fetus not known to be at risk. Ultrasound Obstet Gynecol 2002; 19: 629-31.

93. Prenatal diagnosis of acrania associated with facial defects, amniotic bands and limb-body wall complex. Ultrasound Obstet Gynecol 2002; 20: 94-5.

94. Microcephaly with dysgenesis of corpus callosum and colpocephaly in the survivor after the first trimester death of a monochorionic co-twin. Prenat Diagn 2002; 22: 634-6.

95. Second-trimester molecular diagnosis of a stop codon FGFR3 mutation in a type I thanatophoric dysplasia fetus following abnormal ultrasound findings. Prenat Diagn 2002; 22: 736-7.

96. Identification of unexpected parental Robertsonian (13q;14q) translocations following prenatal sonographic detection of holoprosencephaly. Ultrasound Obstet Gynecol 2002; 20: 304-5.

97. Perinatal imaging findings of inherited Sotos syndrome. Prenat Diagn 2002; 22: 887-92.

98. Second-trimester diagnosis of digynic triploidy in a case of anhydramnios and fetal cyclopia by ultrasound-guided transabdominal chorionic villus sampling. Ultrasound Obstet Gynecol 2002; 20: 415-6.

99. Prenatal diagnosis of the Dandy-Walker malformation and ventriculomegaly associated with partial trisomy 9p and distal 12p deletion. Prenat Diagn 2002; 22: 1063-6.

100. Prenatal diagnosis of partial trisomy 3p and partial monosomy 11q in a fetus with a Dandy-Walker variant and trigonocephaly. Prenat Diagn 2002; 22: 1112-3.

101. Prenatal visualization of the vasculature of fetal sacrococcygeal teratoma by three-dimensional colour power angiography. Ultrasound Obstet Gynecol 2002; 20: 636-7.

102. Prenatal diagnosis of mosaic ring chromosome 22 associated with cardiovascular abnormalities and intrauterine growth restriction. Prenat Diagn 2003; 23: 40-3.

103. Detection of mosaic isochromosome 20q in amniotic fluid in a pregnancy with fetal arthrogryposis multiplex congenita and normal karyotype in fetal blood and postnatal samplings of placenta, skin, and liver. Prenat Diagn 2003; 23: 85-7.

104. Prenatal identification of a G338E mutation in FGFR2 in a fetus without sonographic appearance of craniosynostosis. Prenat Diagn 2003; 23: 175-6.

105. Prenatal diagnosis of de novo mosaic distal 18q deletion associated with congenital anomalies. Ultrasound Obstet Gynecol 2003; 21: 202-4.

106. Two- and three-dimensional ultrasound demonstration of a giant epignathus. Ultrasound Obstet Gynecol 2003; 21: 407-9.

107. Early second-trimester diagnosis of monozygotic twins discordant for cystic hygroma colli and Turner syndrome. Prenat Diagn 2003; 23: 352-3.

108. Second-trimester sonographic detection of short rib-polydactyly syndrome type II (Majewski) following an abnormal maternal serum biochemical screening result. Prenat Diagn 2003; 23: 353-5.

109. Successful triplet pregnancy and delivery after oocyte donation in an infertile female with chromosome mosaicism for monosomy X, partial trisomy X, and terminal Xp deletion. Fertil Steril 2003; 79: 1231-3.

110. Second-trimester sonographic demonstration of retrognathia and bilateral pyelectasis in a fetus with a duplication of chromosome 10q24.1®qter. Ultrasound Obstet Gynecol 2003; 21: 516-8.

111. Prenatal diagnosis of de novo terminal deletion of chromosome 7q. Prenat Diagn 2003; 23: 375-9.

112. Perinatal findings and molecular cytogenetic analysis of trisomy 16q and 22q13.3 deletion. Prenat Diagn 2003; 23: 504-8.

113. Prenatal diagnosis of right pulmonary agenesis associated with VACTERL sequence. Prenat Diagn 2003; 23: 515-8.

114. Prenatal diagnosis of de novo partial trisomy Xq (Xq22.1®qter) and terminal Xp deletion following sonographic detection of intrauterine growth restriction. Prenat Diagn 2003; 23: 518-9.

115. Association of partial trisomy 9 (9pter®q22.3) with corpus callosum dysgenesis, bilateral subependymal cysts and ventriculomegaly. Prenat Diagn 2003; 23: 519-20.

116. Prenatal sonographic diagnosis of limb-body wall complex with craniofacial defects. Ultrasound Obstet Gynecol 2003; 22: 101.

117. Second-trimester evaluation of fetal sacrococcygeal teratoma using three-dimensional power Doppler ultrasound and magnetic resonance imaging. Prenat Diagn 2003; 23: 602-3.

118. Prenatal diagnosis of otocephaly with microphthalmia/anophthalmia using ultrasound and magnetic resonance imaging. Ultrasound Obstet Gynecol 2003; 22: 214-5.

119. Prenatal diagnosis of trisomy 18p and distal 21q22.3 deletion. Prenat Diagn 2003, 23: 758-61.

120. Congenital retroperitoneal cystic teratoma mimicking a cystic lymphangioma on perinatal ultrasound. Prenat Diagn 2003; 23: 763-5

121. Prenatal diagnosis of cephalothoracopagus janiceps disymmetros using three-dimensional color Doppler ultrasound and magnetic resonance imaging. Ultrasound Obstet Gynecol 2003; 22: 299-304.

122. Distal 10q trisomy associated with bilateral hydronephrosis in infancy. Genet Counsel 2003; 14: 359-62.

123. Fetoplacental and fetoamniotic chromosomal discrepancies in prenatally detected mosaic trisomy 9. Prenat Diagn 2003; 23: 1019-21

124. Second-trimester diagnosis of mosaic idic(20)(p11) confined to amniocytes without an abnormal phenotype. Genet Counsel 2003; 14: 439-41.

125. Prenatal imaging of the fetal anterior chest wall cystic hygroma by magnetic resonance imaging. Prenat Diagn 2003; 23: 1099-100

126. Prenatal diagnosis of premature centromere division-related mosaic variegated aneuploidy. Prenat Diagn 2004; 24: 19-25.

127. Clinical, cytogenetic, and molecular findings of prenatally diagn