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李英雄講座教授

現任﹕中國醫藥大學暨附設醫院顧問

中國醫藥大學醫學系專任講座教授

Name: Ying-shiung Lee, MD, FCCP, FICA, FACA, FIBA, FABIRA

Office Address: 199, Tung Hwa North Road, Taipei, Taiwan台灣台北市敦化北路199號

Tel.: (03) 3281200 ext. 8170, 8172 Fax: (03) 3271192

Birth Place: Taiwan

Birth date: Feb. 1, 1943

Sex: Male

Married Status: Married

Spouse’s Name: Chiung-yun Chen/Housewife/Jan. 3, 1946 (35/1/3) 陳瓊雲

Children’s Name: Ming-hsu Lee/Male/62/2/1李旻熹Wan-ju Lee/Female/63/6/1 李婉如

I.D. No.: E100833700

Education (Medical school-year graduated):

June 1969, College of Medicine, National Taiwan University國立台灣大學醫學院醫學系

Post-graduation Education:

Position/Title Name of Company, University, etc. Date

1 Residentship (R1-CR) Department of Internal Medicine, 1970-74

住院及總住院醫師 National Taiwan University Hospital

國立台灣大學醫學院附設醫院

2 Fellowship in Cardiology Division of Cardiology, 1974-76

心臟科研究員 Department of Internal Medicine,

National Taiwan University

國立台灣大學醫學院附設醫院

Academic Appointments:

(Taiwan)

1 Visiting Lecture College of Medicine, National Taiwan University 1974-76

兼任講師國立台灣大學醫學院

2 Lecture College of Medicine, National Taiwan University 1976-77

講師國立台灣大學醫學院

3 Visiting Professor Taipei Medical College 1978-present

兼任教授台北醫學院

4 Visiting Associate Prof. Chung Yuan University 1980-81

兼任副教授中原大學

5 Professor College of Medicine, Chang Gung University 1987-2005.1.31

教授長庚大學醫學院

6 Director Graduate Institute of Clinic Medicine 1995-2001

所長 College of Medicine , Chang Gung University

長庚大學醫學院

臨床醫學研究所

7 Dean College of Medicine 1998-2003.8

院長 Chang Gung University

長庚大學醫學院

(China)

1 Guest Prof. & Researcher Chinese Academy of Sciences 1990-present

客座教授及研究員 (Beijing Laboratory of Electron Microscopy)

中國科學院，北京電子顯微鏡室

2 Guest Prof. Beijing Medical University 1993-present

客座教授北京醫科大學

3 Guest Prof. China Medical University 1993-present

客座教授中國醫科大學

4 Guest Prof. Fujen Medical University 1994-present

客座教授福建醫科大學

5 Guest Prof. Shanghai Medical University 1996-1999

客座教授上海醫科大學

6 Guest Prof. Beijing University 1998-2000

客座教授北京大學

7 Guest Prof. Yang Jou University 2001-present

客座教授揚州大學

8 Guest Prof. Cheng Du Univ.of Traditional Chinese Medicine 2003.11-present

客座教授成都中醫藥大學

Professional Activity:

1 Attending Doctor and Director of Chang Gung Memorial Hospital 1977-2000

Cardiovascular Department

心臟血管內科系主任長庚紀念醫院

2 Vice-superintendent Chang Gung Memorial Hospital 1995-2004.9.30

副院長長庚紀念醫院

3 Chief Executive Official Traditional Chinese Medicine 1998-2004.9.30

執行長 Chang Gung University

Chang Gung Memorial Hospital

長庚中醫藥體系

4 President Research & Development Council 2003.8-2004.9.30

主席 Chang Gung University

Chang Gung Memorial Hospital

長庚研究發展委員會

5 Superintendent Tzu Chi General Hospital 2004.10.1-11.30

院長佛教慈濟綜合醫院、新店

學歷 June 1969, 國立台灣大學醫學院醫學系

經歷

(Taiwan)

1 兼任講師台灣大學醫學院 1974-76

2 講師台灣大學醫學院 1976-77

3 兼任教授台北醫學院 1978-present

4 兼任副教授中原大學 1980-81

5 教授長庚大學醫學院 1987-2005.1.31

6 心臟血管內科系主任長庚紀念醫院 1977-2000

7 副院長長庚紀念醫院 1995-2004.9.30

8 所長長庚大學醫學院 1995-2001

臨床醫學研究所

9 院長長庚大學醫學院 1998-2003.8

10執行長長庚中醫藥體系 1998-2004.9.30

11主席長庚研究發展委員會 2003-2004.9.30

12 院長佛教慈濟綜合醫院、新店 2004.10.1-11.30

(China)

1 客座教授及研究員中國科學院，北京電子顯微鏡室 1990-present

2 客座教授北京醫科大學 1993-present

3 客座教授中國醫科大學 1993-present

4 客座教授福建醫科大學 1994-present

5 客座教授上海醫科大學 1996-1999

6 客座教授北京大學 1998-2000

7客座教授揚州大學 2001-present

8 客座教授成都中醫藥大學

Bibliography:

I. Journals (International, No. 1-93, Domestic, No. 94-123)

1. Ying-Shiung Lee, Yun-Yin Chou: Pathogenetic mechanism of senile calcific aortic stenosis: the role of apoptosis, Chinese Medical Journal, Beijing, China 111(10): 934-939, 1998

2. Ying-Shiung Lee, Yun-Yin Chou: Electron Microscopic Observations of Apoptotic Cells in Various Etiologies of Human Cardiovascular Diseases, Chinese Medical Journal, Beijing, China 111(5): 428-432, 1998

3. Ying-Shiung Lee, Yun-Yin Chou: Molecular level investigation of exocytosis in cultured human pheochromocytoma cells: insights from high resolution scanning electron microscopy combined with autoradiogram and cytochemistry, Chinese Medical Journal, Beijing, China 111(4): 295-301, 1998

4. Ying-Shiung Lee: Calcification of porcine bioprosthesis implanted into human heart: High resolution scanning electron microscopic and scanning tunneling microscopic investigation. Journal of Electron Microscopy 43: 131-140, 1994

5. Ying-Shiung Lee: Morphogenesis of calcification in procine bioprosthesesis: Insight from high resolution electron microscopic investigation at molecular and atomic resolution. Journal of Electron Microscopy, 42: 156-165, 1993

6. Ying-Shiung Lee, Yun-Yin Chou: Intracellular crystallization mechanism in cultured pheochromocytoma cell model: Insight from high resolution electron microscopy. Acta Microscopica (Invited paper, 1: 27-36, 1992, 1992)

7. Ying-Shiung Lee: High-resolution electron microscopic investigation of crystalline cholesterol monohydrate in human atheroma at the atomic level. Micron and Microscopica Acta. 21: 1-12, 1990

8. Ying-Shiung Lee, Ching-Ping Lee: Ultrastructural pathological study of left ventricular myocardium in patients with isolated rheumatic mitral stenosis with normal or abnormal left ventricular function. Japanese Heart Journal. 31: 435-448, 1990

9. Ying-Shiung Lee, Ching-Ping Lee: The secretory granules in human ventricular cardiomyocytes: An electron microscopic immunocytochemical study. Japanese Heart Journal. 31: 661-670, 1990

10. Ying-Shiung Lee: Alterations of anionic molecular organization in basement membrane ultrastructures of human myocardial cells and capillaries in diseased state. Journal of Applied Cardiology 3: 47-56, 1988 (Invited paper)

11. Ying-Shiung Lee: High resolution electron microscope lattice images f powdered gallstones. Micron and Microscopica Acta 18: 281-290, 1987

12. Ying-Shiung Lee, Tsu-Shiu Hsu: Relationship between reestablishment of sarcolemma-glycocalyx ultrastructures and restoration of transmembrane potentials in cultured rat heart cells. Journal of Electrocardiology 29: 303-311, 1987.

13. Ying-Shiung Lee: Alternations of ultrastructures and anionic sites in basement membranes of myocardial cells and capillaries in patients with cyanatic congenital heart disease due to tetralogy of Fallot. Japanese Heart Journal 28: 333-347, 1987

14. Ying-Shiung Lee: Appraisal of polyethyleneimine used as a tracer for anionic sites in human cardiac tissues with a brief reference to anionic molecular organization in altered basement membranes. Journal of Molecular and Cellular Cardiology. 18: 529-539, 1986

15. Ying-Shing Lee: Pathophysiological mechanisms of altered transmembrane potentials in diseased human atria. Journal of Electrocardiology 19: 41-59, 1986

16. Ying-Shiung Lee: Alternations of ultrastructure and anionic molecular organization in the basement membranes of chronic uremic myocardium. American Journal of Nephrology 6: 435-442, 1986

17. Ying-Shiung Lee: Ultrastructural observations of chronic uremic lungs with special reference to histochemical and X-ray microanalytic studies on altered alveolocapillary basement membranes. American Journal of Nephrology 5: 255-266, 1985

18. Ying-Shiung Lee: Effects of adenosine on transmembrane potential and sarcolemmal Na-K ATPase activity of human atrial myocardium. Japanese Heart Journal 26: 69-80, 1985

19. Ying-Shiung Lee, Fan-Yu Lee, Ar-Huey Lu et al.: Biochemical analysis and electron microscopy of human mitral valve collagen in patients with various etiologies of mitral valve disease. Japanese Heart Journal 24: 529-538, 1983

20. Ying-Shiung Lee, Chau-Hsiung Chang, Hsin-Chin Chen et al.: Scanning and transmission electron microscopic studies on isolated ruptures of chorade tendineae. Japanese Heart Journal 24: 355-365, 1983

21. Ying-Shiung Lee, Chau-Hsiung Chang, Reu-Bee Hsu: The relationship of transmembrane potential to surface morphology of human atrial muscle and cardiac hemodynamics. Japanese Heart Journal 24: 41-58, 1983

22. Ying-Shiung Lee, Yn-Tz Sung, Chau-Hsiung Chang: Scanning eletron microscopy of human lungs in various forms of heart disease, Japanese Heart Journal 23: 919-930, 1982

23. Ying-Shiung Lee, Yn-Tz Sung, Chau-Hsiung Chang: The surface morphology and ultrastructure of renal arterial smooth muscle cells in patients with renovascular hypertension. Japanese Heart Journal 23: 509-525, 1982.

24. Ying-Shiung Lee, Yn-Tz Sung, Chau-Hsiung Chang: The surface morphology of the infundibular muscle in patients with tetralogy of Fallot. Japanese Heart Journal 22: 779-787, 1981

25. Ying-Shiung Lee: Electron Microscopic Studies on the alverolarcapillary barrier in the patients of chronic pulmonary edema. Japanese Circulation Journal 43: 945-954, 1979

26. Ying-Shiung Lee, Wen-Pin Lien: His bundle electrogram in rheumatic mitral valve disease with special reference to Bachmann's bundle block in P mitral. Japanese Circulation Journal 39: 935-945, 1975

27. Ying-Shiung Lee, Wen-Pin Lien: Left ventricular approach for recording His bundle potential in man. Chest, 67: 696-701, 1975

28. Yu-shien Ko, Hung I Yeh, Yu-lin Ko, yu-chun Hsu, Chin-fen Chen, Semon Wu, Ying-shiung Lee and Nicholas J, Severs: Three-dimensional reconstruction of the rabbit atrioventricular conduction axis by combining histological, desmin and connexin mapping data. Circulation 109: 1172-1179, 2004

29. C H Chiu, L H Su, C Chu, J H Chia, T L Wu, T Y Lin, Y S Lee, J T Ou: Isolation of Samlmonella enterica serotype choleraesuis resistant to ceftriaxone and ciprofloxacin. The Lancet, No. 9417 363: 1285-1286, 2004

30. Pao-hsien Chu, Hung-I Yeh, Shih-ming Jung, Li-ying Chien, Nai-feng Cheng, Hsueh-hua Wu, Jaw-ji Chu, Chuen Hsueh and Ying-shiung Lee: Irregular connexin43 expressed in a rare cardiac hamartoma containing adipose tissue in the crista terminalis. Virchows Arch 444: 383-386, 2004

31. P H Chu, S M Jung, H H Wu, L Y Chien, C Hsueh, J J Chu and Y S Lee: Apoptosis in primary cardiac tumors. 2004 Blackwell Publishing Ltd Int J Clin Prac, 58: 6, 559-563, June 2004

32. Yu-shien Ko, Hung-yi Yeh, Yu-lin Ko, Yu-chun Hsu, Chin-fen Chen, Semon Wu, Ying-shiung Lee and Nicholas J. Severes. Thre-dimensional reconstruction of the rabbit atrioventricular conduction axis by combining histological, desmin, and connexin mapping data. Circulation 109: 1172-1179, 2004

33. Chin-hung Tsai, Tai-long Pan, Ying-shiung Lee, Yen-kuang Tai and Tsan-zon Liu: Evidence that high-dose L-Arginine may be inappropriate for use by diabetic patients as a prophylactic blocker of methylglyoxal glycation. Journal of Biomedical Science 676: April 29, 2004

34. Chi-jen Chang, Po-jen Ko, Lung-an Hsu, Yu-shien Ko, Yu-lin Ko, Chin-fen Chen, Chiu-ching Huang, Tsu-shiu Hsu, Ying-shiung Lee and Jong-hwei S. Pang: Highly increased cell Proliferation activity in the restenotic hemodialysis vascular access after percutaneous transluminal angioplasty: Implication in prevention of Restenosis. American Journal of Kidney Disease, Vol. 43, No. 1: 74-84, 2004

35. Lung-An Hsu, Yu-Lin Ko, Semon Wu, Ming-Sheng Teng, Tsui-Yi Peng, Chun-Fei Chen, Chin-Fen Chen and Ying-Shiung Lee: Association between a Novell 11-base pair deletion mutation in the promoter region of the scavenger receptor class B type I gene and plasma HDL cholesterol levels in Taiwanese Chinese. Arterioscler Thromb Vasc Biol. 23: 1869-1874, 2003

36. Chi-jen Chang, Lung-an Hsu, Cheng-wen Chiang, Yu-shien Ko, Lai-chu See, Yung-chi Shen, Yu-lin Ko, Chi-tai Kou, Ying-shiung Lee and Jong-Hwei S. Pang: Percutaneous transvenous mitral valvulotomy normalizes elevated circulating levels of tumor necrosis factor-a and interleukin-6 in mitral stenosis with heart failure. The American Journal of Cardiology 91: April 15, 2003

37. Chi-tai Kuo, Nazar Luqman, Kuo-hung Lin, Nye-jan Cheng, Tsu-shiu Hsu and Ying-shiung Lee: Atrioventricular nodal reentry tachycardia with multiple AH jumps: electrophysiological Characteristics and radiofrequency ablation. Pace, 26: 1849-1855, 2003

38. Jee-ching Hsu, Ying-shiung Lee, Chen-nen Chang, Huo-li Chuang, Eng-ang Ling, Chyn-tair Lan: Sleep deprivation inhibits expression of NADPH-d and NOS while activating microglia and astroglia in the rat hippocampus. Cells Tissues Organs 173: 242-254, 2003

39. Semon Wu, Yu-shien Ko, Ming-sheng Teng, Yu-lin Ko, Lung-an Hsu, Chuen Hsueh, Yung-yin Chou, Choong-chin Liew and Ying-shiung Lee: Adriamhcin-induced cardiomyocyte and endothelial cell apoptosis: in vitro and in vivo studies. J Mol Cell Cardiol 34, 1595-1607, 2002

40. Lung-an Hsu, Yu-lin Ko, Kuang-hung Hsu, Yu-hsien Ko, Ying-shiung Lee: Genetic variations in the cholesteryl ester transfer protein gene and high density lipoprotein cholesterol levels in Taiwanese Chinese. Hum Genet, 110:57-63, 2002

41. Lung-an Hsu, Yu-lin Ko, Shu-Mei Wang, Chi-jen Chang, Tsu-Shiu Hsu, Cheng-wen Chiang, Ying-shiung Lee: The C677T Mutation of the methylenetetrahydrofolate reductase gene is not associated with the risk of coronary artery disease or venous thrombosis among Chinese in Taiwan. Human Heredity, 51: 41-45, 2001

42. Hsiu-chuan yen, Huey-shinn Cheng, Yi-tsu Hsu, Huey-jing Ho, Chung-yi Nien and Ying-shiung Lee: Effects of age and health status on levels of urinary 15-F21-Isoprostane. J Biomed Lab Sci 13: No. 1, 2001

43. Tsu-shiu Hsu, Lung-an Hsu, Chi-jen Chang, Chien-feng Sun, Yu-lin Ko, Chi-tai Kuo, Cheng-wen Chiang and Ying-shiung Lee: Importance of hyperhomocysteinemia as a risk factor for venous thromboembolism in a Taiwanese population. A case-control study. Thrombosis Research, 102: No. 5, June 1 2001

44. Shyh-ming Chen, Nye-jan Cheng, Po-hsien Chu, Yu-lin Ko, Cheng-wen Chiang and Ying-shiung Lee: Sinoatrial nodal artery aneurysm with right ventricular outflow Tract compression: Report of a case. Catheterization and Cardiovascular Interventions 51: 328-331, 2000

45. Paul Chan, Shue-Sen Liao, Chao-Tien Hsu, Ying-Shiung Lee, Brian Tomlinson, Jon-Son Kuo, Juei-Tang Cheng: Comparison of superoxide dismutase gene expression and activity in the brain of spontaneously hypertensive rats with that in normotensive rat. Chinese Medical Journal, Beijing, China 112(11): 1999

46. Chi-Tai Kuo, Kuo-Hung Lin, Nye-Jan Cheng, Po-Hsien Chu, Tsu-Shiu Hsu, Cheng-Wen Chiang, Ying-Shiung Lee: Characterization of atrioventricular nodal reentry with continuous atrioventricular node conduction curve by double atrial extrastimulation. Circulation, 99(5): 659-665, 1999

47. Ber-ren Fang, Cheng-wen Chiang and Ying-shiung Lee: Pre-operative and Post-operative Echocardiographic study in 12 patients with left atriall myxoma. Mary Ann Liebert, Inc. 16: No. 2, 1999

48. Ber-ren Fang, Chiung-tsung Li, Li-tang Kuo, Cheng-wen Chiang and Ying-shiung Lee: Echocardiographic detection of right heart strain in a patient who presents with shock: a clue to acute pulmonary embolism. 16: No 2, 1999

49. Yu-Lin Ko, Yu-Shien Ko, Shu-Mei Wang, Lung-An Hsu, Chi-Jen Chang, Po-Hsien Chu, Nye-Jan Cheng, Wei-Jan Chen, Chen-Wen Chiang, Ying-Shiung Lee: The Gln-Arg 191 polymorphism of the human paraoxonase gene is not associated with the risk of coronary artery disease among Chinese in Taiwan. Atherosclerosis, 141: 259-264, 1998

50. Chang Chi-Jen, Chou Yun-Ying, Ying-Shiung Lee: Electron microscopic studies of microvasculature and sympathetic nerve fibers in dilated cardiomyopathy. Chinese Medical Journal, Beijing, China 111(10): 929-933, 1998

51. Chou Yun-Ying, Ying-Shiung Lee: Ultrastructural and biochemical characterization of catecholamine release mechanisms in cultured human pheochromocytoma cells. Chinese Medical Journal, Beijing, China 111(11): 1018-1024, 1998

52. Cheng-Wen Chiang, Long-An Hsu, Po-Hsien Chu, Yu-Shien Ko, Yu-Lin Ko, Nye-Jan Cheng, Ying-Shiung Lee, Pying-Jing Lin, Chau-Hsiung Chang: On-line Multiplane Transesophageal Echocardiography for Balloon Mitral Commissurotomy. The American Journal of Cardiology 81: 515-518, 1998

53. Paul Chan, Brian Tomlinson, Tsuei-Yuen Huang, Jiing-Tang Ko, Tz-Shing Lin, Ying-Shiung Lee: Double-Blind Comparison of Losartan, Lisinopril, and Metolazone in Elderly Hypertensive Patients with Previous Angiotensin-Converting Enzyme Inhibitor-Induced Cough. J Clin Pharmacol 37: 253-257, 1997

54. Paul Chan, Tsuei-Yuen Huang, Brian Tomlinson, Clarita Lee, Ying-Shiung Lee: Short-Term Safety and Efficacy of Low-Dose Simvastatin in Elderly Patients with Hypertensive Hypercholesterolemia and Fasting Hyperinsulinemia. J Clin Pharmacol 37: 496-501, 1997

55. Pyng-Jing Lin, Chau-Hsiung Chang, Cheng-Wei Hsiao, Yen Chu, Hui-Ping Liu, Hung-Chang Hsieh, Kuei-Ton Tsai, Ming-Jang Hsieh, Yun-Ying Chou, Ying-Shiung Lee: Cardiopulmonary bypass, myocardial management, and support techniques. The Journal of Thoracic and Cardiovascular Surgery 114: 100-108, 1997

56. Paul Chan, Chun-Nai Lin, Brian Tomlinson, Tz-Hsin Lin, Ying-Shiung Lee: Additive effects of diltiazem and lisinopril in the treatment of elderly patients with mild-to-moderate hypertension. American Journal of Hypertension 10: 743-749, 1997

57. Po-Hsien Chu, Wei-Jan Chen, Pyng-Jing Lin, Wer-Ber Liao, Cheng-Wen Chiang, Ying-Shiung Lee: Thrombectomy for Left Ventricular Protruding Thrombi in a Patient with Dilated Cardiomyopathy. Japanese Heart Journal 38: 531-534, 1997

58. Po-Hsien Chu, Wei-Jan Chen, Cheng-Wen Chiang, Ying-Shiung Lee: Rhabdomyolysis, Acute Renal Failure and Hepatopathy Induced by Lovastatin Monotherapy. Japanese Heart Journal 38: 541-545, 1997

59. Yu-Lin Ko, Yu-Shien Ko, Shu-Mei Wang, Po-Hsien Chu, Ming-Sheng Teng, Nye-Jan Cheng, Wei-Jan Chen, Tsu0Shiu Hsu, Chi-Tai Kuo, Cheng-Wen Chiang, Ying-Shiung Lee: Angiotensinogen and Angiotensin-1 Converting Enzyme Gene Polymorphisms and the Risk of Coronary Artery Disease in Chinese. Human Genetics 100: 210-214, 1997

60. Yu-Lin Ko, Yu-Shien Ko, Shy-Meeng Wu, Ming-Sheng Teng, Fu-Ru Chen, Tsu-Shiu Hsu, Cheng-Wen Chiang, Ying-Shiung Lee: Interaction between obesity and genetic polymorphisms in the apolipoprotein CIII gene and lipoprotein lipase gene on the risk of hypertriglyceridemia in Chinese, Human Genetics 100: 327-333 1997

61. Paul Chan, Brian Tomlinson, Ching-Bing Lee, Wen-Harn Pan, Ying-Shiung Lee: Beneficial effects of pravastatin on Fasting Hyperinsulinemia in Elderly Hypertensive Hypercholesterolemic Subjects. American Heart Association, Inc. 28: 647-651, 1996

62. Paul Chan, Brain Tomlinsoin, Chung-Wen Tsai, Wen-Harn Pan, Ying-Shiung Lee: Thrombophilia in patients with hypercholesterolemia. Metabolism 45: 966-969, 1996

63. Ko Yu Lin, Tsu-shiu Hus, Shy Meeng Wu, Yu Shien Ko, Chi Jen Chang, Shu Mei Wang. Wei Jan Chen, Nye Jan Cheng, Chi Tai Kuo, Chen-Wen Chiang, Ying-Shiung Lee: The G1691A mutation of the coagulation factor V gene (factor V Leiden) is rare in Chinese: an analysis of 618 individuals. Human Genet 98: 176-177, 1996

64. Paul Chan, Brian Tomlinson, Ching-Bing Lee, Ying-Shiung Lee: Effectiveness and safety of low-dose pravastatin and squalene, alone and in combination, in elderly patients with hypercholesterolemia. J Clin Pharmacol 36: 422-427, 1996

65. Ber-Ren Fang, Cheng-Wen Chiang, Ying-Shiung Lee: Echocardiographic Detection of Reversible right ventricular strain in patients with acute pulmonary embolism: report of 2 cases. Cardiology 87: 279-282, 1996

66. Paul Chan, Ching-Bing Lee, Tz Shing Lin, Jiing Tang Ko, Wen-Harn Pan, Ying Shiung Lee: The effectiveness and safety of low dose pravastatin in elderly hypertensive hypercholesterolemic subjects on antihypertensive therapy. American Journal of Hypertension 8: 1099-1104, 1995

67. Paul Chan, T H Lin, W H Pan and Ying Shiung Lee: Thrombophilia associated with obesity in ethnic Chinese. International Journal of Obesity 19: 756-759, 1995

68. Wen-Jin Cherng, Cheng-Wen Chiang, Chi-Tai Kuo, Ching-Ping Lee, Ying-Shiung Lee: A comparison between intravenous streptokinase and tissue plasminogen activator with early intravenous heparin in acute myocardial infarction. American Heart Journal 123: 841-846, 1992

69. Chi-Tai Kuo, Cheng-Wen Chiang, Ber-Ren Fang, Ching-Ping Lee, Tsu-Shiu Hsu, Ying-Shiung Lee, Chau-Hsiung Chang: Coronary artery fistula: Diagnosis by transesophageal two-dimensional and doppler echocardiography. American Heart Journal 123: 218-220, 1992

70. Chi-Tai Kuo, Cheng-Wen Chiang, Ying-Shiung Lee, Yat-Sen Ho, Chau-Hsiung Chang: Left atrial ball thrombus in nonrheumatic atrial fibrillation diagnosed by transesophageal echocardiography. American Heart Journal 123: 1394-1397, 1992.

71. Chi-Tai Kuo, Cheng-Wen Chiang, Ming-Shyan Chern, Ying-Shiung Lee, Chau-Hsiung Chang: Imaging of multiple coronary artery fistulas to right ventricle by transthoracic and transesophageal echocardiography. Chest 102: 1623-1625, 1992

72. Paul Chan, Ching-Ping Lee, Ying-Shiung Lee: High output cardiac failure caused by multiple giant cutaneous hemangiomas. Japanese Heart Journal 33: 493-497, 1992

73. Paul Chen, Ching-Ping Lee, Ying-Shiung Lee: Budd-Chiar: Syndrome treated successfully by percutaneous transluminal ballon angioplasty: Two cases follow-up for 6 years. Catheterization and Cardiovascular Diagnosis 27: 215-219, 1992

74. Tsu-Shiu Hsu, Ying-Shiung Lee: Endopoints of treadmill exercise testing for functional evaluation of patients with mitral stenosis. International Journal of Cardiology. 31: 81-87, 1991

75. Rong-Chi Tsai, Tohru Yamaji;, Miyuki Ishibashi, Fumimaro Takaku, Shih-Tien Hsu, San-Jou Yeh, Ying-Shiung Lee: Role of atrial natriuretic peptide in hemoconcentration during exercise. American Journal of Hypertension 8: 823-837, 1990

76. Sarah O. Chua, Cheng-Wen Chiang, Ying-Shiung Lee, Chau-Hsiung Chang, Jui-Sung Hung: Perforated aneurysm of the anterior mitral valve. A doppler and two-dimensional echocardiographic report. Chest 97: 753-754, 1990

77. Ber-Ran Fang, Cheng-Wen Chiang, Fun-Chung Lin, Ying-Shiung Lee, Chau-Hsiung Chang: Two-dimensional and doppler echocardiographic features of coronary arteriovenous fistula. Report of three cases. Journal of Ultrasound in Medicine 9: 39-43, 1990

78. Ber-Ren Fang, Cheng-Wen Chiang, Jui-Sung Hung, Ying-Shiung Lee: Cardiac myxoma-clinical experience in 24 patients. International Journal of Cardiology. 29: 335-341, 1990

79. Lucy H.A. Young, Sanjay V. Joag, Li-Mou Zheng, Ching-Ping Lee, Ying-Shiung Lee, John Ding-E Young: Perforin-mediated myocardial damage in acute myocarditis. Lancet 336: 1019-1021, 1990

80. Sarch O. Chua, Cheng-Wen Chiang, Ying-Shiung Lee, Yun-Fan Liaw, Chau-Hsiung Chang, Jui-Sung Hung: Echocardiographic findings of mobils atrial hepatocellular carcinoma. Report of five cases. Journal of Ultrasound in Medicine 8: 347-352, 1989

81. Cheng-Wen Chiang, Fen-Chung Lin, Ber-Ran Fang, Chi-Tai Kuo, Ying-Shiung Lee, Chau-Hsiung Chang: San-drift echoes and thrombus formation in the left atrium. American Heart Journal 115: 908-911, 1988

82. Cheng-Wen Chiang, Fen-Chiung Lin, Ber-Ran Fang, Chi-Tai Kuo, Ying-Shiung Lee, Chau-Hsiung Chang: Doppler and two-dimensional echocardiographic features of sinus of valsalva aneurysm. American Heart Journal 116: 1283-1288, 1988

83. Rong-Chi Tsai, Tohru Yamaji, Miyuki Ishibashi, Fuminaro Takaku, Siu-Cheong Pang, San-Jou Yeh, Ying-Shiung Lee, Jui-Sung Hung, Delon Wu: Atrial natriuretic peptide during supraventricular tachycardia and relation to hemodynamic changes and renal function. American Journal of Cardiology 61: 1260-1264, 1988

84. Siu-Cheong Pang, Cheng-Wen Chiang, Morgan Fu, Fun-Chung Lin, Ching-Ping Lee, San-Jou Yeh, Chi-Tai Kuo, Tsu-Shiu Hsu, Ying-Shiung Lee: Early diagnosis of acute myocardial infarction by myoglobin latex agglutination test. Japanese Heart Journal 29: 631-638, 1988

85. Cheng-Wen Chiang, Siu-Cheong Pang, Fen-Chung Lin, Ber-Ran Fang, Chi-Tai Kuo, Ying-Shiung Lee, Chau-Hsiung Chang: Diagnostic accuracy of two-dimensional echocardiography for detection of left atrial thrombus in patients with mitral stenosis. Journal of Ultrasound in Medicine 6: 525-529, 1987

86. Rong-Chi Tsai, Tohru Yamaji, Miguki Ishibashl, Fuminaro Takaku, San-Jou Yeh, Ying-Shiung Lee, Tai-Shung Jung, Delon Wu: Mechanism of polyuria and natriuresis associated with paroxysmal supraventricular tachycardia. Japanese Heart Journal 28: 203-209, 1987

87. Sarach O Chua, Cheng-Wen Chiang, Ying-Shiung Lee, Shi-Hui Lin, Yun-Fan Liaw: Moving right atrial mass associated with hepatoma two cases detected by echocardiography. Chest 89: 723-726, 1986

88. Pyng-Jing Lin, Chau-Hsiung Chang, Ying-Shiung Lee, Yun-Ying Chou, Jaw-Ji Chu, Jen-Ping Chang, Ming-Jang Hsieh: Acute endothelial reperfusion injury after coronary artery bypass grafting. Annals of Thoracic Surgery 1986

89. Chen-Wen Chiang, Fen-Chung Lin, Morgan Fu, Ber-Ran Fang, Tsu-Shiu Hsu, Ying-Shiung Lee: Importance of adequate gas-mixing in contrast echocardiography. Chest 89: 723-726, 1986

90. Cheng-Wen Chiang, Ying-Shiung Lee, Chau-Hsiung Chang et al.: Preoperative and postoperative echocardiographic studies of pulmonic valvular endocarditis. Chest 80: 232-234, 1981

91. Wen-Pin Lien, Ying-Shiung Lee, Fu-Zen Chang et al.: Left ventricular performance in various heart diseases with or without heart failure: An appraisal by quantitative one-plane cineangiography. Japanese Circulation Journal 42: 11-27, 1978

92. Wen-Pin Lien, Ying-Shiung Lee, Fu-Zen Chang et al.: The sick sinus syndrom. Natural history of dynfunction of the sino-atrial node. Chest 72: 628-634, 1977

93. Wen-Pin Lien, Ying-Shiung Lee, Fu-Zen Chang et al.: Studies on advanced rheumatic mitral insufficiency: Clinical aspects and circulatory dynamics with aspecial reference to their correlations. Japanese Circulation Journal, 38: 667-681, 1974

94. Ying-Shiung Lee, Yun-Ying Chou: Endothelial alterations and senilc calcific aortic stenosis: An electron microscopic observation. Proceedings of the National Science Council, R.O.C. 21: 137-143 (Part B: Life Science), 1997

95. Ying-Shiung Lee, Hsiu-Ching Chen, Shu-May Lai: High resolution electron microscopic investigation of atomic structural images in human atherosclerotic plaque. Proceedings of the National Science Council, R.O.C. 16: 169-176 (Part B: Life Science), 1992

96. Ying-Shiung Lee, Tai-Lin Lieu: Relationship between chromosomal aberrations and nuclear alterations induced in cultured rat heart cells by adriamycin. J. Formosan Med. Assoc., 87: 857-865. 1988

97. Ying-Shiung Lee, Hsin-Chin Chen, Kan-Fang Liang et al.: Scanning and transmission electron microscopic studies on pulmonary bullae. J. Formosan Med. Assoc. 83: 542-550, 1984

98. Ying-Shiung Lee, Wen-Pin Lien, Michael Y. Shen et al.: Dynamic changes of coronary sinus enzyme activities during selective coronary cinearteriography. J. Formosan Med. Assoc., 70: 548-555, 1980

99. Ying-Shiung Lee, Tsu-Shiu Hsu, Wen-Pin Lien et al.: Hemodynamic and metabolic studies on congestive liver. J. Formosan Med. Assoc., 79: 280-285, 1980

100. Ying-Shiung Lee, Wen-Pin Lien, Michael Y. Shen et al.: Cardiac enzyme study in the diagnosis of acute myocardial infarction: Simultaneous determinations of creatine phosphokinase isoenzyme and lactate dehydrogenase isoenzymes. J. Formosan Med. assoc., 76, 604-611, 1977

101. Ying-Shiung Lee, Wen-Pin Lien, Fu-Zen Chang et al.: Secondary hypertension due to renovascular disease of adrenal tumors: A proposal approach of renal vein catheterization with adrenal venography. J. formosan Med. Assoc., 76: 317-323, 1977

102. Ying-Shiung Lee, Wen-Pin Lien and Fu-Zen Chang: Studies on the left ventricular performance: Evaluation based upon the force-velocity relations of the left ventricular muscle in various heart disease. J. Formosan Med. Assoc., 76: 119-127, 1977

103. Ying-Shiung Lee: A new trial on microtopographical study of the human cardiac muscles: A preliminary report on scanning electron microscopic findings. J. Formosan Med. Assoc., 74: 590-595, 1975

104. Ying-Shiung Lee, Wen-Pin Lien, Yen-Yau Hsieh et al.: Constrictive pericarditis: Experience over 12 years at the National Taiwan University Hospital. J. Formosan Med. Assoc., 72, 581-596, 1973

105. Chi-Tai Kuo, Nazar Luqman, Kuo-Hung Lin and Ying-Shiung Lee: Atrial Fibrillation: New Horizons. The Chang Gung Medical Journal., 26, 712-721, 2003

106. Ber-Ren Fand, Cheng-Wen Chiang, Ying-Shiung Lee: Hepatoma associated with a floating right atrial mass. J Med Ultrasound. 3: 85-87, 1995

107. Chi-Tai Kuo, Chin-Yi Liu, Tsu-Shiu Hsu, Cheng-Wen Chiang, Ying-Shiung Lee: Immediate prognostic significance of complete atrioventricular block in acute myocardial infarction. J. Formosan Med. Assoc., 88: 712-717, 1989

108. Cheng-Wen Chiang, Fun-Chung Lin, Ber-Ren Fang, Chi-Tai Kuo, Wen-Chin Cherng, Ying-Shiung Lee: Doppler echocardiographic findings in healthy chinese adults. J. Formosan Med. Assoc., 88: 772-777, 1989

109. Chi-Tai Kuo, Ying-Shiung Lee, Chin-Yi Liu et al.: Characteristics and prognostic implications of nonsustained ventricular tachycardia in ambulatory patients without definite coronary artery disease. J. Formosan Med. Assoc., 86: 104-111, 1987

110. Wen-Jin Cherng, Cheng-Wen Chiang, Fun-Chiung Lin, Morgan Fu, Ber-Ren Fang Tsu-Shiu Hsu, Ying-Shiung Lee: Persistent left superior vena cava with special reference on echocardiographic finding. J. Formosan Med. Assoc., 85: 239-248, 1986

111. Tsu-Shiiu Hsu, Cheng-Wen Chiang, Ying-Shiung Lee, Jui-Sung Hung: Treadmill exercise testing in patients with significant coronary artery diseae. J. Formosan Med. Assoc., 156-166, 1984

112. Tsu-Shiu Hsu, Yung-Ying-Chou, Ying-Shiung Lee: Does plasma lipid change during therapy with calcium antagonists. J. Formosan Med. Assoc., 83: 905-911, 1984

113. Tsu-Shiu Hsu, Cheng-Wen-Chiang, Ying-Shiung Lee, Jui-Sung Hung: Measurement of R wave amplitude in treadmill exercise tests- A simplified method and its clinical application. J. Formosan Med. Assoc., 83: 986-995, 1984

114. Yn-Tz Sung, Ying-Shiung Lee, Yu-Ling Hu: An ultrastructural study of myocardial preservation during cadiopulmonary bypass. J. Formosan Med. Assoc., 80: 1135-1144, 1981

115. Yn-Tz Sung, Ying-Shiung Lee and Chau-Hsiung Chang: Altered collagen fibril structure in the spontaneous rupture of chordae tendinease. J. Formosan Med. Assoc., 80: 649-652, 1981

116. Tsu-Hsiu Hsu, Cheng-Wen Chiang, Ying-Shiung Lee et al.: Experience of treadmill exercise testing in ischemic heart disease. J. Formosan Med. Assoc., 80: 740-750, 1981

117. Tsu-Shiu Hsu, Chun-Yueh Wen, Ying-Shiung Lee et al.: Appraisal of doppler ultrasonic flowmetry in the diagnosis of peripheral vascular disease. J. Formosan Med. Assoc., 79: 706-713, 1980

118. Jin-Jer Chen, Wen-Pin Lien, Ying-shiung Lee et al.: Pacemaker therapy in symptomatic sinoatrial node disease (Sick sinus syndrome). J. Formosan Med. Assoc., 76: 10-18, 1977

119. Yen-Yau Hsieh, Ying-Shiung Lee, Fu-Zen Chang et al.: The Roman-Ward syndrome: A case report. J. Formosan Med. Assoc., 76: 286-291, 1977

120. Fu-Zen Chang, Wen-Pin Lien, Ying-Shiung Lee et al.: Congenital coarctation of the aorta in adults: Fifteen Years' experience at the National Taiwan University Hospital. J. Formosan Med. Assoc., 75: 1-10, 1976

121. Wen-Pin Lien, Chi-Ren Hung, Ying-Shiung Lee et al.: Permanent transvenous demand pacemaker in clinical practice at the National Taiwan University Hospital. J. Formosan Med. Assoc., 74: 263-279, 1975

122. Wen-Pin Lien and Ying-Shiung Lee: Atrioventricular conduction disturbance in adults with secundrum atrial septal defect. J. Formosan Med. Assoc., 73: 623-636, 1974

123. Wen-Pin Lien, Ying-Shiung Lee, Fu-Zen Chang et al.: Intracardiac electrocardiography and its usefulness for the assessment of conduction disturbance of the heart. J. Formosan Med. Assoc., 73: 471-500, 1974

II. Proceedings of Electron Microscopy (International Congress)

1. Ying-Shiung Lee: Molecular structures of isolated basement membrane in man. Proceedings of the 41st Annual Meeting of Electron Microscopy Society of American (Phoenix, Arizona). 1983, 514-515

2. Ying-Shiung Lee: Anionic molecular organization in isolated sarcolemma of human heart muscle. Proceedings of the 42nd Annual Meeting of Electron Microscopy Society of America (Detroit, Michigan). 1984, 236-237.

3. Ying-Shiung Lee: Electron Microscopic cytochemical characterization of anionic sites in human cardiac basement membranes. Proceedings of the XIth International Congress on Electron Microscopy (Kyoto, Japan). 1986, 2713-2714

4. Ying-Shiung Lee: Electron microscopic studies on membrane repair of isolated rat heart cells in culture. Proceedings of the XIth International Congress on Electron Microscopy (Kyoto, Japan). 1986, 2721-2722

5. Ying-Shiung Lee: High resolution electron microscopic cytochemical investigation of cardiovascular pathomorphology at the molecular and atomic level. Proceedings of the IVth Asia-Pacific Conference and Workshop on Electron Microscopy (Bangkok, Thailand). 1988, 375-380. (Invited paper on symposium)

6. Ying-Shiung Lee: Electron microscopic characterization of biomolecules and atoms. Proceedings of the 3rd Beijing Conference and Exhibition on Instrumental Analysis (Beijing, China). 1989, A 131-132. (Invited paper on symposium)

7. Ying-Shiung Lee: Atomic structural images of crystalline cholesterol monohydrate in human atheroma. Proceedings of the XIth International Congress for Electron Microscopy (Seattle, U.S.A.). 3: 206-207, 1990

8. Ying-Shiung Lee, Ching-Ping Lee: Immunoelectron microscopic study of secretory granules containing atrial natriuretic peptide in human ventricular cardiomyocytes. Proceedings of the XIIth International Congress for Electron Microscopy (Seatle, U.S.A.). 3: 874-875, 1990

9. Ying-Shiung Lee, Yun-Ying Chou: High resolution electron microscopic investigation of intracellular crystallization processes at the atomic level in the cultured cell model. International Symposium on Electron Microscopy (Beijing, China). 1990, 159-167. (Invited paper on symposium)

10. Ying-Shiung Lee: Application of high resolution electron microscopy in molecular and atomic-level investigation of biological and clinical materials. 5th Asia-Pacific Electron Microscopy Conference (Beijing, China). 1992 II, 22-27. (Invited paper on plenary lectures)

11. Yun-Ying Chou, Shi-Mei Lin, Ying-Shiung Lee: Morphological and biochemical characteristics of catecholamines secretion from pheochromocytoma cells. 5th Asia-Pacific Electron Microscopy Conference (Beijing, China). 1992 II, 100-101

12. Ying-Shiung Lee: Mechanism of bioprosthetic valves calcification: New insights from high resolution scanning electron microscopy and scanning tunneling microscopy. 13th International Congress on Electron Microscopy. Applications in biological sciences, Volume 3B; 1159-1160, 1994

III. Conference Abstracts on International and World Congress of Cardiology, Angiology and Pulmonology