張竣維   助理教授

電子郵箱: hebronchang2005@yahoo.com

電話 : (04)2332-3456轉1831

研究領域 :

生化和分析毒理學，液相色譜質譜分析，氣相色譜質譜分析，代謝物定性定量分析，藥物毒物代謝動物學

學歷 :

美國印第安那州聖母大學 (University of Notre Dame) 生物化學博士

東海大學生物研究所碩士

輔仁大學生物系學士

經歷 :

亞洲大學                                                                  助理教授                        現任

南京醫科大學                                                                特聘教授                        2003~2005

美國阿肯色兒童營養中心 (ACRC, USDA) 副研究員                       2001~2003

美國藥品食品管理局,國家毒理研究中心 (NCTR, USFDA)

訪問研究員                       1997~2001

美國阿肯色州立醫科大學藥理毒理所                博士後研究員        1995~1997

臺灣生物技術開發中心                        研究員              1994~1995

美國猶他州立大學生物技術中心                        研究助理                        1988~1990

行政院农委会農業藥物毒物試驗所                    助理研究員                    1981~1988

學術研究工作及成果:

1987 ~ 1988                          農藥藥害果皮組織染色檢驗法

1989 ~ 1990                          含氮農藥白腐菌生物降解法

1991 ~ 1994                          含氮農藥過氧化酶生化反應降解法

                                                過氧化酶生化反應降解含氮農藥代謝物

（4-chloroaniline）的機制研究

1994 ~ 1995                          研發地下水石油含硫環境污染物生物降解法

1995 ~ 1997  `                       維生素甲抗氧化機制與其代謝物研究

1999 ~ 2000                          過氧化酶蛋白肽與4-chloroaniline共價結合位點研究

1997 ~ 2001                          植物雌性激素大豆異黃酮及其代謝物研究究）的關係

2001~ 2005                           植物雌性激素大豆異黃酮及其代謝物在動物模型及人體的研究

                                                大豆異黃酮代謝物于白鼠，小豬及人類尿液中的代謝物組學研究

2004~2005                            黃芪甲甙于白鼠的藥物代謝研究

學術榮譽:

1984 ~ 1988                          國科會研究成果獎1

社會服務：            美國聖母大學中國同學會會長

                美國阿肯色州華人同鄉會會長

                   南京醫科大學英文學報編委

                                    中國藥理學會生殖藥理專業委員

 著作 :

1.        J Yu, HC Chang*, S Sun, Y Zhang, J Luo, R Zhao, J Han, J SHen, F Wang. 2005. Pharmacokinetics study of astragaoside IV by intervenous administration with intermittent sampling in intact rats.  Pharmaco. Res. (submitted)

2.        Hebron C. Chang,  Myriam Laly, Melody Harrison and Thomas M. Badger. 2005. Hydrolysis of soy isoflavone conjugates using enzyme may underestimate isoflavone concentrations in tissue.  J. Nanjing Medical Univ. 19:10-14

3.        Ting Zhu, Rui Chen, Aiping Li, Jia Liu, Dengan Gu, Qizhan Liu Hebron C. Chang and Jianwei Zhou. 2005. JWA as a novel molecule involved in oxidative stress associated signal pathway in K562 cells. Cell Stress & Chaperones  (submitted)

4.        Rui Chen,  Aiping Li, Ting Zhu, Chunping Li, Qizhan Liu, Hebron C. Chang and Jianwei Zhou.  2005. JWA-- a novel environmental responsive gene, involves in estrogen receptor associated signal pathway in MCF-7 and MDA-MB-231 breast carcinoma cells. J. Toxicol. Environ. Health   (in press)

5.        T Zhu, R Chen, A Li, J Liu, Q Liu, HCChang and J Zhou. 2005. The formation of 8-hydroxy deoxyguanosine and the role of JWA in oxidative damage in K562 and MCF-7 cells. J Biomed. Sci. (in press)

6.        LB Cui, Y,Shi GD Dai, HX Pan, JF Chen, L Song, SL Wang, HC Chang, HB Shen and XR Wang. Modification of N-Methyl-N-Nitrosourea Initiated Bladder Carcinogenesis in Wistar Rats by Terephthalic Acid. Toxicol Appl Pharmacol, in press.

7.        Li-Chun Xu, Hong Sun, Shu-yi Wang, Ling Song, Hebron C. Chang and Xin-Ru Wang. 2005.  The role of metallothionein on cadmium-induced testes damages in Sprague-Dawley Rats. Environ. Toxicol. Pharma. (in press)

8.        GD Dai, LB Cui, L Song, N Gong, JF Chen, RZ Zhao, SL,Wang, HC Chang  XR Wang. Terephthalic Acid Occupational Exposure and Its Effect on Organ Functions in Fiber Workers. Environ Toxicol Pharmacol, 2005, 20: 209-214.

9.        J. He, J. F. Chen, R. H. C. Chang and X. R. Wang. 2005. Fenvalerate-induced alterations in calcium homeostass in rat. Biomed. Enviroment. Sci.  (in press)

10.    YK Xia, SP Cheng, Q Bian, LC Xu, MD Collins, HC Chang, L,Song JY Liu, SL Wang, XR Wang. 2005 Genotoxic effects on spermatozoa of carbaryl-exposed workers. Toxicol Sci., 85: 615-623.

11.    J. He, J. F. Chen, R. Liu, S. L. Wang, L. Song, H. C. Chang and X. R. Wang. 2004. Alteration of FSH-stimulated progesterone production and calcium homeostasis in primarily cultured human leteinizing-granulosa cells induced by Fenvalerate. Toxicology 203: 61-68.

12.    Q Bian, L C Xu, S L Wang, Y K Xia, L F Tan, J F Chen, L Song, H. C. Chang and XR Wang.  2004. Study on the relationship between occupational fenvalerate exposure and spermatozoa DNA damage of pesticide factory workers. Occu. Environ. Med. 61: 999-1005.

13.    Hebron C. Chang, Myraim Laly, Ronald D. Prior and Thomas M. Badger. 2004.  Formononetin, an isoflavone metabolite found in the liver of rats fed diets containing soy protein isolate. J Food Drug Anal. 16:161-166.

14.    Hebron C. Chang, Ronald R. Prior, and Thomas M. Badger.  2004.  Urinary profiles of soy isoflavone metabolites in woman, female pig and female rat consuming soy diet. J. Nanjing Medical Univ. 18：57-66.

15.    Danile R. Doerge and Hebron C. Chang. 2002.  Inactivation of thyroid peroxidase by soy isoflavones, in vitro and in vivo.  J Chromatogr. B. 777:269-279.

16.    Daniel R. Doerge, Nathan C. Twaddle, Mona. I.  Churchwell, Hebron C. Chang, Retha P. Newbold, and K. Barry Delclos. 2002. Mass spectrometric determination of p-nonylphenol metabolism and disposition following oral administration to Sprague-Dawley rats. Repro. Toxicol. 16:45-56.

17.    Hebron C. Chang and Cathy Y. W. Ang. 2001. Analytical method development for determination of bioactive components of St. John’s Wort (Hypericum perforatum L.) in functional foods. (CFSAN report)

18.    Hebron C. Chang and John A. Bumpus. 2001.  Iodide oxidation and iodine reduction by horseradish peroxodase in the presence of EDTA: the superoxide effect.  Proc. Nat. Sci. Coun., part B, 25(2): 82-89.

19.    Daniel R. Doerge, Mona I. Churchwell, Hebron C. Chang and K. Barry Delclos. 2001.  Placental transfer of the soy isoflavone, genistein, following dietary and gavage administration to Sprague-Dawley rats. Reprod. Toxicol. 15:105-110.

20.    Hebron C. Chang and John A. Bumpus. 2001.  Inhibition of lignin peroxidase-mediated oxidation activity by EDTA and TEMED.  Proc. Nat. Sci.  Coun.  part B, 25(1):26-33.

21.    Hebron C. Chang, Robert L. Rountree  and Lii-Sin Leu. 2000. Electron microscopic observation of unripe banana fruit infected with Colletotrichum musae. Plant Prot. Bull. 42(3):135-146.

22.    Hebron C. Chang and Victor M. Samokyszyn.  2000.  Biotransformation of 13(Z)-retinoic acid in mouse skin and human keratinocyte cultures. Koahsiung J Med. Sci. 16:387-392.

23.    Hebron C. Chang, John E. Seng, Julian E. A. Leakey and Jay Gandy.  2000.  Metabolism of flutamide in diet control rats, and its hydroxylation and conjugation by human CYP450s and UGT-glucuronosyltranferases.  J Food Drug Anal. 8(3): 166-173.

24.    Hebron  C. Chang and  Daniel R. Doerge.  2000. Dietary genistein causes inactivation of rat thyroid peroxidase in vivo without an apparent hypothyroid effect.  Toxicol. Appl. Pharma. 168(3): 244-252.

25.    Hebron C. Chang, Mona I. Churchwell, K. Barry Delclos, and Daniel R. Doerge.  2000. Mass spectrometric determination of genistein tissue distribution in Sprague Dawley rats from        dietary exposure. J. Nutrition 130:1963-1970.

26.    Daniel R. Doerge, Hebron C. Chang, Mona I. Churchwell, and C. Lee Holder.  2000. Analysis of soy isoflavone conjugation in vitro and in human blood using LC/MS. Drug Metab.  D. 28(3):298-307.