李尚熾助理教授 授課大綱
最高學歷：國立清華大學生命科學院博士
研究領域：生物技術、蛋白質生化與訊號傳遞、免疫與基因治療
電子郵件信箱：李尚熾助理教授
sclee@thmu.edu.tw
分機：(04)-23323456
轉 1838
壹、 個人簡要經歷
亞洲大學生物資訊學系專任助理教授2003年8月-
亞洲大學生活應用科學系專任助理教授2002年2月-
2003年7月
貳、著作、作品及發明目錄
(A).期刊論文
1. Jau-Song Yu, Shan-Chih Lee, and Shiaw-Der Yang (1995) Effect of Mg+2 concentrations
on phosphorylation/activation of phosphorylase b kinase by cAMP/Ca+2-dependent,
autophosphorylation-dependent protein kinase. J. Protein Chem. 14, 747-752.
(SCI)
2. Shan-Chih Lee and Shiaw-Der Yang (1996) Calphostin C induces tyrosine dephosphorylation/inactivation
of protein kinase FA/GSK-3 in a pathway independent of tumor promoter phorbol
ester-mediated down-regulation of protein kinase C. J. Cell. Biochem. 60,121-129.
(SCI)
3. Shiaw-Der Yang, Hsiou-Chen Chang, and Shan-Chih Lee (1996) Okadaic acid,
sphingosine, and phorbol ester reversibly modulate heat induction of protein
kinase FA/GSK-3 in A431 cells. J. Cell. Biochem. 60, 218-225. (SCI)
4. Shiaw-Der Yang, Jau-Song Yu, Chuan-Ching Yang, Shan-Chih Lee, Tsong-Tze Lee,
Mei-Hui Ni, Chu-Yun Kuan, and Hsiang-Chin Chen (1996) Overexpression of protein
kinase FA/GSK-3 (a proline-directed protein kinase) correlates with human hepatoma
dedifferntiation/ progression. J. Cell. Biochem. 61, 238-245. (SCI)
5. Shiaw-Der Yang, Shan-Chih Lee, and Hsiou-Chen Chang (1997) Heat stress induces
tyrosine phsphorylation/activation of protein kinase FA/GSK-3 (a carcinoma differentiation
modulator) in A431 cells. J. Cell. Biochem. 66, 16-26. (SCI)
6. Shan-Chih Lee, Chu-Yun Kuan, Zen-Der Wen, and Shiaw-Der Yang (1998) The naturally-occurring
PKC inhibitor sphingosine and tumor promoter phorbol ester potentially induce
tyrosine phosphorylation/ activation of oncogenic proline-directed protein kinase
FA/GSK-3 in a common signaling pathway. J. Protein Chem. 17, 15-27. (SCI)
7. Shan-Chih Lee, Chu-Yun Kuan, Chuan-Ching Yang, and Shiaw-Der Yang (1998)
Bioflavonoids commonly and potently induce tyrosine dephosphorylation/inactivation
of oncogenic proline-directed protein kinase FA in human prostate carcinoma
cells. Anticancer Res. 18, 1117-1121. (SCI)
8. Shan-Chih Lee, Chang-Jer Wu, Pin-Yi Wu, Yi-Ling Huang, Chen-Wen Wu, and Mi-Hua
Tao (2003) Inhibition of established subcutaneous and mestastatic murine tumors
by instramuscular electroporation of the interleukin 12 gene. J. Biomed. Sci.10,
73-86. (SCI)
9. Shan-Chih Lee, Chia-Hui Lo, Pin-Yi Wu, Wen-Yu Pan, Jui Su, Steve R. Roffler,
Bor-Luen Chiang, Chun-Nan Lee, Chen-Wen Wu, and Mi-Hua Tao (2003) Antitumor
and antimetastatic activity of interleukin 23. J. Immunol. Accepted for publication.
10. Chang-Jer Wu, Shan-Chih Lee, Hae-Wun Huang, Wae-Yan Yu, and Mi-Hua Tao (2003)
In vivo electroporation of skeletal muscles increases the efficacy of Japanese
encephalitis virus DNA vaccine. Submitted to vaccine.
(B)專書及專書論文
1. 李尚熾 1997 脯氨酸引導的蛋白質激酉每 FA在癌細胞中的訊號傳遞與功能角色 清華大學生命科學研究所博士論文. 新竹
2. 陶秘華,李尚熾 2003 疫苗發展技術與實驗:基因疫苗 教育部生物技術教育改進計畫-動物基因轉殖與疫苗發展技術教學資源中心編撰.
參、 近年研究計畫
發展RNA干擾基因療法治療人類子宮頸癌 國科會 92年8月至93年7月