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葉貞吟 專任副教授

 

最高學歷﹕美國奧瑞岡州州立大學博士 (1991-1995)


主要經歷

                  亞洲大學專任副教授(2003/08-)


             
逢甲大學環境工程與科學學系兼任助理教授 (2003-)


             
國家衛生研究院環境衛生與職業醫學研究組助理研究員 (2000-2003)


                  靜宜大學食品營養學系兼任助理教授 (2001)   


分機﹕(04)-23323456轉1851


信箱﹕jyyeh@asia.edu.tw


主要研究領域﹕細胞分子毒物、抗氧化研究、分子生物技術、基因調控、動物細胞生理
 

期刊著作

Shen, H. D., Choo, K. B., Tsai, W. C., Jen, T. M., Yeh, J. Y. and Han, S. H. (1988) Differential identification of Candida species and other yeasts by analysis of [35S]-methionine-labeled polypeptide profiles. Anal. Biochem. 175:548-551.

Shen, H. D., Choo, K. B., Tang, R. B., Lee, C. F., Yeh, J. Y, and Han, S. H. (1989) Allergenic components of Candida albicans identified by immunoblot analysis. Clin. Exp. Allergy 19:191-195.

Yeh, J. Y., Ou, B. R. and Forsberg, N. E. (1992) Amino acid transport system L in muscle cells: biochemical properties and its relation to protein synthesis. Biochim. Biophys. Acta 1108:1-7.

Yeh, J. Y., Ou, B. R. and Forsberg, N. E. (1994) Effects of dexamethasone on muscle protein degradation and calpain and calpastatin activities and gene expression in rabbits. J. Endocrinology 141:209-217.

Liu, C. C., Yeh, J. Y., Ou, B. R. and Forsberg, N. E. (1994) Actions of beta-adrenergic agonist on muscle protein metabolism in intact, adrenalectomized and dexamethasone-supplemented adrenalectomized rats. J. Nutri. Biochem. 5:43-49.

Yeh, J. Y., Beilstein, M. A., Andrews, J. S. and Whanger, P. D. (1995) Tissue distribution and influence of selenium status on levels of selenoprotein W. FASEB J. 9:392-396.

Hong, D. H., Huan, J., Ou, B. R., Yeh, J. Y., Saido, T. C., Cheeke, P. R. and Forsberg, N. E. (1995) Protein kinase C isoforms in muscle cells and their regulation by phorbol ester and calpain. Biochim. Biophys. Acta. 1267(1):45-54.

Vendeland, S. C., Beilstein, M. A., Yeh, J. Y., Ream, L. W. and Whanger, P. D. (1995) Rat skeletal muscle selenoprotein W: cDNA clone and mRNA modulation by dietary selenium. Proc. Natl. Acad. Sci. USA 92:8749-8753.

Yeh, J. Y. and Whanger, P.D. (1995) Biochemistry and Molecular Biology of Selenium. In: Environmental Bioinorganic Chemistry of Selenium. Ed. Peng, A., Wang, C., Whanger, P. D., Combs, G. F. and Yeh, J. Y. pp.76-90. People Republic of China.

Yeh, J. Y., Ou, B. R., Forsberg, N. E. and Whanger, P. D. (1997) Effects of selenium and serum on selenoprotein W in cultured L8 muscle cells. BioMetals 10:11-22.

Yeh, J. Y., Vendeland, S. C., Gu, Q., Butler, J. A., Ou, B. R. and Whanger, P. D. (1997). Dietary selenium increases selenoprotein W levels in rat tissues. J. Nutr. 127:2165-2172.

Yeh, J. Y., Gu, Q., Beilstein, M. A., Forsberg, N. E. and Whanger, P. D. (1997) Selenium influences tissue levels of selenoprotein W in sheep. J. Nutr. 127:394-402.

Yeh, J. Y., Ou, B. R., Gu, Q., Butler, J. A. and Whanger, P. D. (1998) Influence of gender on selenoprotein W, glutathione peroxidase and selenium in tissues of rats. Comp. Biochem. Physiol. 119B(1):151-155.

Sun, Y., Ha, P. C., Butler, J. A., Ou, B. R., Yeh, J. Y. and Whanger, P. D. (1998) Effect of dietary selenium on selenoprotein W and glutathione peroxidase in 28 tissues of rat. J. Nutri. Biochem. 9:23-27.

Yeh, J. Y., Cheng, L. C., Ou, B. R., Whanger, P. D. and Chang, L. W. (2002) Differential influences of various arsenic compounds on glutathione redox status and antioxidative enzymes in porcine endothelial cells. Cell. Mol. Life Sci. 59:1972-1982.

Liang, Y. C., Yeh, J. Y. and Ou, B. R. (2003) Overexpression of porcine growth/differentiation factor 8 recombinant protein in Baculovirus expression system. J. Clin. Soc. Anim. Sci. 32:23-32.

Yeh, J. Y., Cheng, L. C., Chang, L. W. and Ou, B. R. (2003) Modulation of the arsenic effects on cytotoxicity, cell viability and cell cycle in porcine endothelial cells by selenium. Endothelium 10: 127-139.

Cheng, Y. H., Cheng, L. C., Ou, B. R. and Yeh, J. Y. (2003) Regulation of glutathione turnover in porcine aortic endothelial cells treated with various arsenic compounds. J. Toxicol. (submitted)

Chung, T. C., Liang, Y. C., Yeh, J. Y. and Ou, B. R. (2004) Stabilization of calpain large subunits by overexpression of truncated calpain small subunit in L8 myoblasts. Tissue and Cell. (in press)

Yeh, J. Y., Cheng, L. C. and Ou, B. R. (2003) Effect of various arsenic compounds on cell proliferation and the influence of arsenic-induced hydrogen peroxide on cellular glutathione peroxidase activity and glutathione level in rat C6 glial cells, rat L8 myoblasts and MDCK cells. (in preparation)

Yeh, J. Y., Chen, S. H., Whanger, P. D. and Ou, B. R. (2003) Gender and age differences of Selenoprotein W distribution in mice. (in preparation)


論文摘要:

Yeh, J. Y., Ou, B. R. and Forsberg, N. E. (1990) Novel regulation of amino acid transport in skeletal muscle. Presented at American Society of Cell Biology Meeting in San Diego, CA. U.S.A. J. Cell Biol. 111:430a.

Yeh, J. Y., Ou, B. R. and Forsberg, N. E. (1991) Regulation of muscle cell leucine transport at the level of protein synthesis. Presented at American Society of Animal Science Annual Meeting, U.S.A. J. Anim. Sci. 69:317.

Yeh, J. Y., Ou, B. R., Hong, D. H. and Forsberg, N. E. (1993) Effects of dexamethasone on muscle protein degradation and calpains and calpastatin activities and gene expression in rabbits. Presented at American Society of Animal Science Annual Meeting in Spokane, WA. U.S.A. J. Anim. Sci. 71:125.

Hong, D. H., Ou, B. R., Yeh, J. Y. and Forsberg, N. E. (1993) Protein kinase C isoforms in muscle cells. Presented at American Society of Animal Science Annual Meeting in Spokane, WA. U.S.A. J. Anim. Sci. 71:127.

Yeh, J. Y., Andrews, J., Vendeland, S., Beilstein, M. and Whanger, P. (1994) Immunological studies with selenoprotein W from rat muscle. Presented at Experimental Biology Meeting in Anaheim, CA. U.S.A. The FASEB J. 8:A434.

Gu, Q., Yeh, J. Y., Beilstein, M. A., Forsberg, N. E. and Whanger, P. D. (1995) Effect of selenium status on selenoprotein W distribution in sheep tissues. Presented at Experimental Biology Meeting in U.S.A.

Vendeland, S. C., Yeh, J. Y., Mohd, A., Ream, L. W. and Whanger, P. D. (1995) Tissue distribution and effect of selenium deficiency on rat selenoprotein W mRNA levels. Presented at Experimental Biology Meeting in U.S.A.

Yeh, J. Y., Whanger, P. D. and Ou, B. R. (1995) Effects of selenium and serum on selenoprotein W and glutathione peroxidase in cultured L8 muscle cells. J. Clin. Soc. Anim. Sci. 24 (Suppl.):141.

Yeh, J. Y., Whanger, P. D. and Ou, B. R. (1996) Differential expression of selenoprotein W in male and female rats. J. Clin. Soc. Anim. Sci. 25 (Suppl.):134.

Chen, S. H., Hong, R. W., Yeh, J. Y. and Ou, B. R. (2000) Tissue distribution of selenoprotein W and the age-related differential distribution in mice. J. Clin. Soc. Anim. Sci. 28 (Suppl.):157.

Yeh, J. Y., Cheng, L. C., Ou, B. R. and Chang, L. W. (2001) Effects of various arsenic compounds on the proliferation of MDCK, C6 and L8 cell lines. The International Symposium of Cellular Biology in Asia, Taipei, Taiwan R.O.C.

Cheng, L. C., Ou, B. R., Chang, L. W. and Yeh, J. Y. (2002) Modulation on the arsenic effects on cell proliferation, cell viability and cell cycle in porcine endothelial cells by selenium. The 17th Joint Annual Conference of Biomedical Science, Taipei, Taiwan R.O.C.

Yeh, J. Y., Cheng, L. C., Cheng, Y. H., Chang, L. W. and Ou, B. R. (2002) Differential influences of various arsenic compounds on glutathione redox status and antioxidative enzymes. The 4th Asian-Pacific Organization for Cell Biology Congress, Taipei, Taiwan R.O.C.

Liang, Y. C., Yeh, J. Y. and Ou, B. R. (2002) The role of porcine growth/differentiation factor 8 recombinant protein in muscle development. J. Clin. Soc. Anim. Sci. 31(4):174.

Cheng, L. C., Yeh, S. C., Ou, B. R., Cheng, Y. H., Chang, L. W. and Yeh, J. Y. (2003) Arsenic excretion in procine aortic endothelial cells. The 18th Joint Annual Conference of Biomedical Science, Taipei, Taiwan R.O.C.

Cheng, Y. H., Cheng, L. C., Chang, L. W. and Yeh, J. Y. (2003) Glutathione turnover in porcine aortic endothelial cells treated with various arsenic compounds. The 18th Joint Annual Conference of Biomedical Science, Taipei, Taiwan R.O.C.


近年之研究計畫:

1. Glutathione system and environmental contaminant-induced oxidative stress. 1/1/2001-12/31/2001 (NHRI EO-090-PP-06)
2. Glutathione turnover and arsenic toxicity. 1/1/2002-12/31/2002 (NHRI EO-091-PP-05)
3. Involvement of multidrug resistance transporters in arsenic detoxification pathway. 1/1/2003-12/31/2003 (NHRI EO-092-PP-02)

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